Zobrazeno 1 - 10
of 39
pro vyhledávání: '"David W Keizer"'
Publikováno v:
BBA Advances, Vol 2, Iss , Pp 100062- (2022)
Nuclear magnetic resonance (NMR) spectroscopy is well-established nowadays for the elucidation of the 3D structures of proteins and protein complexes, the evaluation of biomolecular dynamics with atomistic resolution across a range of time scales, th
Externí odkaz:
https://doaj.org/article/ad2283cb7a8b4c88af5e59aa83b5c5d1
Publikováno v:
Biochemical Society Transactions
Alzheimer's disease (AD) is a common neurodegenerative condition that involves the extracellular accumulation of amyloid plaques predominantly consisting of Aβ peptide aggregates. The amyloid plaques and soluble oligomeric species of Aβ are believe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8912283111534a97ff5dfbc1289472e
https://doi.org/10.1042/bst20201244
https://doi.org/10.1042/bst20201244
Publikováno v:
The Journal of chemical physics. 155(22)
The interpretation of molecular translational diffusion as measured by pulsed gradient spin-echo NMR (PGSE NMR) can be complicated by the presence of chemical exchange and/or dipolar cross-relaxation (including relayed cross-relaxation via spin diffu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9632550ad44e47deba74bf9de388a57c
https://pubmed.ncbi.nlm.nih.gov/34911323
https://pubmed.ncbi.nlm.nih.gov/34911323
Publikováno v:
Biophys Rev
Lipidic cubic phase (LCP) structures have been used for stabilisation and crystallisation of membrane proteins and show promising properties as drug carriers. In this mini-review, we present how NMR spectroscopy has played a major role in understandi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::974757f8ddc5da77cda2892fd8d903e6
https://europepmc.org/articles/PMC8921435/
https://europepmc.org/articles/PMC8921435/
Autor:
David W. Keizer, Thomas G. Meikle, Paul R. Gooley, Frances Separovic, Shenggen Yao, Ashish Sethi, Charlotte E. Conn, Jeffrey J. Babon
Publikováno v:
Journal of Magnetic Resonance. 305:146-151
Lipidic cubic phases, which form spontaneously via the self-assembly of certain lipids in an aqueous environment, are highly prospective nanomaterials with applications in membrane protein X-ray crystallography and drug delivery. Here we report 1H-15
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37c7c8dc72fbcdb9bc2c227d54bd08de
https://doi.org/10.1016/j.jmr.2019.06.017
https://doi.org/10.1016/j.jmr.2019.06.017
Publikováno v:
Frontiers in Medical Technology
Antimicrobial peptides (AMPs) have attracted attention as alternatives to classic antibiotics due to their expected limited pressure on bacterial resistance mechanisms. Yet, their modes of action, in particular in vivo, remain to be elucidated. In si
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::010cb63a9a604339844e48cda2f0a13e
http://europepmc.org/articles/PMC8757805
http://europepmc.org/articles/PMC8757805
Autor:
Calum J. Drummond, David W. Keizer, Frances Separovic, Charlotte E. Conn, Jeffrey J. Babon, Shenggen Yao, Thomas G. Meikle
Publikováno v:
Langmuir : the ACS journal of surfaces and colloids. 36(22)
Lipidic inverse bicontinuous cubic phases (LCPs), formed via the spontaneous self-assembly of lipids such as monoolein, have found increasing applications in the stabilization and crystallization of integral membrane proteins for structural character
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d2fa02565c88be937a1b77e0658770a
https://pubmed.ncbi.nlm.nih.gov/32418433
https://pubmed.ncbi.nlm.nih.gov/32418433
Autor:
Colin W. Pouton, Michael R. Whittaker, Michelle P. McIntosh, Shadabul Haque, David B. Ascher, David W. Keizer, Lisa M. Kaminskas
Publikováno v:
Nanomedicine : nanotechnology, biology, and medicine. 30
Polylactide-co-glycolide (PLGA) nanoparticles are one of the most commonly explored biodegradable polymeric drug carriers for inhaled delivery. Despite their advantages as inhalable nanomedicine scaffolds, we still lack a complete understanding of th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32570bb257164cb22b1f19656d856b2e
https://pubmed.ncbi.nlm.nih.gov/32841737
https://pubmed.ncbi.nlm.nih.gov/32841737
Autor:
Jeffrey J. Babon, Thomas G. Meikle, David W. Keizer, Frances Separovic, Shenggen Yao, Ashish Sethi
Publikováno v:
European Biophysics Journal. 47:891-902
Pulsed-field gradient nuclear magnetic resonance has seen an increase in applications spanning a broad range of disciplines where molecular translational diffusion properties are of interest. The current study introduces and experimentally evaluates
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6b7d0e2820587ac60810503c00969d66
https://doi.org/10.1007/s00249-018-1311-5
https://doi.org/10.1007/s00249-018-1311-5
Autor:
W. Douglas Fairlie, David W. Keizer, Shenggen Yao, Erinna F. Lee, Anne Pettikiriarachchi, Marco Evangelista
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics. 1864:1128-1137
Beclin 1 is a 450 amino acid protein that plays critical roles in the early stages of autophagosome formation. We recently reported the successful expression, purification and structural characterisation of the entire N-terminal region of Beclin 1 (r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d74e5f428eb103fc5a6c6cf0642aeed
https://doi.org/10.1016/j.bbapap.2016.06.005
https://doi.org/10.1016/j.bbapap.2016.06.005