Zobrazeno 1 - 10
of 10
pro vyhledávání: '"David W Hong"'
Autor:
Shrilakshmi Hegde, Amy E. Marriott, Nicolas Pionnier, Andrew Steven, Christina Bulman, Emma Gunderson, Ian Vogel, Marianne Koschel, Alexandra Ehrens, Sara Lustigman, Denis Voronin, Nancy Tricoche, Achim Hoerauf, Marc P. Hübner, Judy Sakanari, Ghaith Aljayyoussi, Fabian Gusovsky, Jessica Dagley, David W. Hong, Paul O'Neill, Steven A. Ward, Mark J. Taylor, Joseph D. Turner
Publikováno v:
Frontiers in Microbiology, Vol 15 (2024)
Lymphatic filariasis and onchocerciasis are two major neglected tropical diseases that are responsible for causing severe disability in 50 million people worldwide, whilst veterinary filariasis (heartworm) is a potentially lethal parasitic infection
Externí odkaz:
https://doaj.org/article/7818521273b4477987c6341e4921c6ea
Autor:
Suqing Zhao, Zhiting Lao, Xiping Cui, Kun Zhang, Zhu Qiuyan, Yang Yang, David W. Hong, Yingying Zhong, Zhang Bingjie, Paul M. O'Neill
Publikováno v:
Pest Management Science. 76:636-644
Background The use of safe and effective insecticides against mosquito-borne stocks is still one of the most effective ways to rapidly interrupt the spread of diseases such as malaria, dengue etc., but many insects are resistant to most insecticides
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3aada98e43cf2e85a2d4475090c0703
https://doi.org/10.1002/ps.5559
https://doi.org/10.1002/ps.5559
Autor:
Laura N Jeffreys, Shaun H Pennington, Jack Duggan, Claire H Caygill, Rose C Lopeman, Alastair F Breen, Jessica B Jinks, Alison Ardrey, Samantha Donnellan, Edward I Patterson, Grant L Hughes, David W Hong, Paul M O’Neill, Ghaith Aljayyoussi, Andrew Owen, Stephen A Ward, Giancarlo A Biagini
A key element to the prevention and management of the COVID-19 pandemic is the development of effective therapeutics. Drug combination strategies of repurposed drugs offer a number of advantages to monotherapies including the potential to achieve gre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f3be06334fa54c60b7259c9da3758b2a
https://doi.org/10.1101/2020.12.23.424232
https://doi.org/10.1101/2020.12.23.424232
Autor:
Laura N. Jeffreys, Shaun H. Pennington, Jack Duggan, Claire H. Caygill, Rose C. Lopeman, Alastair F. Breen, Jessica B. Jinks, Alison Ardrey, Samantha Donnellan, Edward I. Patterson, Grant L. Hughes, David W. Hong, Paul M. O'Neill, Ghaith Aljayyoussi, Andrew Owen, Stephen A. Ward, Giancarlo A. Biagini
Publikováno v:
International Journal of Antimicrobial Agents
A key element for the prevention and management of coronavirus disease 2019 is the development of effective therapeutics. Drug combination strategies offer several advantages over monotherapies. They have the potential to achieve greater efficacy, to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f59d2dcded9a99b9bcac11c48fcec504
https://doi.org/10.1016/j.ijantimicag.2022.106542
https://doi.org/10.1016/j.ijantimicag.2022.106542
Novel anti-Wolbachia drugs, a new approach in the treatment and prevention of veterinary filariasis?
Publikováno v:
Veterinary Parasitology. 279:109057
Filarial nematodes are tissue-dwelling parasitic worms that can cause a range of disfiguring pathologies in humans and potentially lethal infections of companion animals. The bacterial endosymbiont, Wolbachia, is present within most human and veterin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3eed70f17a48a8d33d033bd1b5dfbef
https://doi.org/10.1016/j.vetpar.2020.109057
https://doi.org/10.1016/j.vetpar.2020.109057
Autor:
Paul M. O'Neill, Alison Mbekeani, Janet Hemingway, Giancarlo A. Biagini, Neil G. Berry, Alison E. Shone, Richard Amewu, Michael J. Delves, Bénédicte Pacorel, Nicholas Fisher, Chandrakala Pidathala, Suet C. Leung, David W. Hong, Robert E. Sinden, James Chadwick, Jill Davies, Murad A. Mubaraki, Gemma L. Nixon, Raman Sharma, Thomas Antoine, Stephen A. Ward, Alisdair Hill, Alexandre S. Lawrenson, Sitthivut Charoensutthivarakul, Abhishek Srivastava, Olivier Berger, Clemens H. M. Kocken, Lee Taylor, Ashley J. Warman, Paul A. Stocks, Anne-Marie Zeeman, Peter Gibbons
Publikováno v:
Proceedings of the National Academy of Sciences. 109:8298-8303
There is an urgent need for new antimalarial drugs with novel mechanisms of action to deliver effective control and eradication programs. Parasite resistance to all existing antimalarial classes, including the artemisinins, has been reported during t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72e4fc34ad06f807aeeaf6df13dc85ca
https://doi.org/10.1073/pnas.1205651109
https://doi.org/10.1073/pnas.1205651109
Autor:
Alasdair Hill, Peter Gibbons, Alison E. Shone, David William Cronk, Gemma L. Nixon, Stephen A. Ward, Chandrakala Pidathala, David W. Hong, Ian K. Gowers, Richard Amewu, Alison Mbekeani, Raman Sharma, Joanne Lesley Shearer, Serge P. Parel, Alexandre S. Lawrenson, Giancarlo A. Biagini, Paul A. Stocks, Ashley J. Warman, Paul M. O'Neill, Suet C. Leung, James Chadwick, Nicholas Fisher, Neil G. Berry
Publikováno v:
Journal of Medicinal Chemistry
Malaria is responsible for approximately 1 million deaths annually; thus, continued efforts to discover new antimalarials are required. A HTS screen was established to identify novel inhibitors of the parasite's mitochondrial enzyme NADH:quinone oxid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a92ac08cbafc0496b020e0ff8983755
https://doi.org/10.1021/jm3001482
https://doi.org/10.1021/jm3001482
Autor:
Aaron T. Wright, Hanafy M. Ismail, Paul M. O'Neill, David W. Hong, Colin J. Henderson, Janet Hemingway, Mark J. I. Paine, Robert D. Finn, Benjamin F. Cravatt
Pyrethroid insecticides are used to control diseases spread by arthropods. We have developed a suite of pyrethroid mimetic activity-based probes (PyABPs) to selectively label and identify P450s associated with pyrethroid metabolism. The probes were s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3d531765a24be6c254e313dcf8fc5b6
https://nrl.northumbria.ac.uk/id/eprint/14690/1/PNAS-2013-Ismail-19766-71.pdf
https://nrl.northumbria.ac.uk/id/eprint/14690/1/PNAS-2013-Ismail-19766-71.pdf
Autor:
Louise Le Pensee, Ashley J. Warman, Richard Amewu, Alison E. Shone, Alison Mbekeani, David W. Hong, Alasdair Hill, Steve A. Ward, Peter Gibbons, Neil G. Berry, Nicholas Fisher, Gemma L. Nixon, Chandra Pidathala, Giancarlo A. Biagini, Raman Sharma, Victoria Barton, Paul A. Stocks, James Chadwick, Paul M. O'Neill
Publikováno v:
Malaria Journal
NADH:quinone oxidoreductase (PfNDH2) represents a metabolic choke point in the respiratory chain of Plasmodium falciparum mitochondria and is the focus of a drug discovery programme. A miniaturised assay for recombinant PfNDH2 with robust assay perfo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1aad4523564649aae24a9f0028f2e0aa
https://doi.org/10.1186/1475-2875-9-s2-o4
https://doi.org/10.1186/1475-2875-9-s2-o4
Autor:
Alasdair Hill, Peter Gibbons, Paul M. O'Neill, Alison E. Shone, David W. Hong, James Chadwick, Giancarlo A. Biagini, Ashley J. Warman, Gemma L. Nixon, Chandra Pidathala, Paul A. Stocks, Raman Sharma, Victoria Barton, Neil G. Berry, Nicholas Fisher, Steve A. Ward, Louise Le Pensee, Richard Amewu, Alison Mbekeani
Publikováno v:
Malaria Journal
Malaria Journal, Vol 9, Iss Suppl 2, p I14 (2010)
Europe PubMed Central
Malaria Journal, Vol 9, Iss Suppl 2, p I14 (2010)
Europe PubMed Central
The mitochondrial respiratory chain of the malaria parasite Plasmodium falciparum differs from that of its human host in that it lacks a canonical protonmotive NADH:ubiquinone oxidoreductase (Complex I), containing instead a single sub-unit, non-prot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12ad656589000027acadee196aee6fe3