Zobrazeno 1 - 10
of 69
pro vyhledávání: '"David W Hawman"'
Autor:
Megan A O'Connor, David W Hawman, Kimberly Meade-White, Shanna Leventhal, Wenjun Song, Samantha Randall, Jacob Archer, Thomas B Lewis, Brieann Brown, Megan N Fredericks, Kaitlin R Sprouse, Hillary C Tunggal, Mara Maughan, Naoto Iwayama, Chul Ahrens, William Garrison, Solomon Wangari, Kathryn A Guerriero, Patrick Hanley, Jamie Lovaglio, Greg Saturday, David Veesler, Paul T Edlefsen, Amit P Khandhar, Heinz Feldmann, Deborah Heydenburg Fuller, Jesse H Erasmus
Publikováno v:
PLoS Pathogens, Vol 19, Iss 4, p e1011298 (2023)
The global SARS-CoV-2 pandemic prompted rapid development of COVID-19 vaccines. Although several vaccines have received emergency approval through various public health agencies, the SARS-CoV-2 pandemic continues. Emergent variants of concern, waning
Externí odkaz:
https://doaj.org/article/d4af23eb43be40bcaa467db922cd5121
Autor:
Alexandra C Willcox, Kevin Sung, Meghan E Garrett, Jared G Galloway, Jesse H Erasmus, Jennifer K Logue, David W Hawman, Helen Y Chu, Kim J Hasenkrug, Deborah H Fuller, Frederick A Matsen Iv, Julie Overbaugh
Publikováno v:
PLoS Pathogens, Vol 18, Iss 4, p e1010155 (2022)
Macaques are a commonly used model for studying immunity to human viruses, including for studies of SARS-CoV-2 infection and vaccination. However, it is unknown whether macaque antibody responses resemble the response in humans. To answer this questi
Externí odkaz:
https://doaj.org/article/d06c3815d7874833bff7c9995c4d3884
Autor:
David W Hawman, Kimberly Meade-White, Jacob Archer, Shanna S Leventhal, Drew Wilson, Carl Shaia, Samantha Randall, Amit P Khandhar, Kyle Krieger, Tien-Ying Hsiang, Michael Gale, Peter Berglund, Deborah Heydenburg Fuller, Heinz Feldmann, Jesse H Erasmus
Publikováno v:
eLife, Vol 11 (2022)
Despite mass public health efforts, the SARS-CoV2 pandemic continues as of late 2021 with resurgent case numbers in many parts of the world. The emergence of SARS-CoV2 variants of concern (VoCs) and evidence that existing vaccines that were designed
Externí odkaz:
https://doaj.org/article/90febf2692524714945d906eb9c6e393
Autor:
David W Hawman, Kimberly Meade-White, Shanna Leventhal, Friederike Feldmann, Atsushi Okumura, Brian Smith, Dana Scott, Heinz Feldmann
Publikováno v:
eLife, Vol 10 (2021)
Crimean-Congo hemorrhagic fever (CCHF) is a severe tick-borne febrile illness with wide geographic distribution. CCHF is caused by infection with the Crimean-Congo hemorrhagic fever virus (CCHFV) and case fatality rates can be as high as 30%. Despite
Externí odkaz:
https://doaj.org/article/497188810ad5471b9b72b5c434a10de3
Autor:
David W. Hawman, Kimberly Meade-White, Chad Clancy, Jacob Archer, Troy Hinkley, Shanna S. Leventhal, Deepashri Rao, Allie Stamper, Matthew Lewis, Rebecca Rosenke, Kyle Krieger, Samantha Randall, Amit P. Khandhar, Linhue Hao, Tien-Ying Hsiang, Alexander L. Greninger, Michael Gale, Jr, Peter Berglund, Deborah Heydenburg Fuller, Kyle Rosenke, Heinz Feldmann, Jesse H. Erasmus
Publikováno v:
EBioMedicine, Vol 83, Iss , Pp 104196- (2022)
Summary: Background: In late 2021, the SARS-CoV-2 Omicron (B.1.1.529) variant of concern (VoC) was reported with many mutations in the viral spike protein that were predicted to enhance transmissibility and allow viral escape of neutralizing antibodi
Externí odkaz:
https://doaj.org/article/ab324282f355407caf9cfe9a89fda64c
Autor:
Shanna S. Leventhal, Kimberly Meade-White, Deepashri Rao, Elaine Haddock, Jacqueline Leung, Dana Scott, Jacob Archer, Samantha Randall, Jesse H. Erasmus, Heinz Feldmann, David W. Hawman
Publikováno v:
EBioMedicine, Vol 82, Iss , Pp 104188- (2022)
Summary: Background: Crimean-Congo hemorrhagic fever virus is the cause of a severe hemorrhagic fever with cases reported throughout a wide-geographic region. Spread by the bite of infected ticks, contact with infected livestock or in the health care
Externí odkaz:
https://doaj.org/article/2faa9f27af3c480298ba8bdae9797f88
Autor:
Kyle Rosenke, Frederick Hansen, Benjamin Schwarz, Friederike Feldmann, Elaine Haddock, Rebecca Rosenke, Kent Barbian, Kimberly Meade-White, Atsushi Okumura, Shanna Leventhal, David W. Hawman, Emily Ricotta, Catharine M. Bosio, Craig Martens, Greg Saturday, Heinz Feldmann, Michael A. Jarvis
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-8 (2021)
While vaccines protecting against SARS-CoV-2 infection are approved, currently, there are no drugs suitable for high-risk exposure use against SARS-CoV-2. Here, Rosenke et al. provide evidence that orally delivered MK-4482, a nucleoside analog, inhib
Externí odkaz:
https://doaj.org/article/9a78a63a312847aa863ae1016f4d581a
Autor:
Kim J. Hasenkrug, Friederike Feldmann, Lara Myers, Mario L. Santiago, Kejun Guo, Bradley S. Barrett, Kaylee L. Mickens, Aaron Carmody, Atsushi Okumura, Deepashri Rao, Madison M. Collins, Ronald J. Messer, Jamie Lovaglio, Carl Shaia, Rebecca Rosenke, Neeltje van Doremalen, Chad Clancy, Greg Saturday, Patrick Hanley, Brian J. Smith, Kimberly Meade-White, W. Lesley Shupert, David W. Hawman, Heinz Feldmann
Publikováno v:
mBio, Vol 12, Iss 4 (2021)
ABSTRACT Severe coronavirus disease 2019 (COVID-19) has been associated with T cell lymphopenia, but no causal effect of T cell deficiency on disease severity has been established. To investigate the specific role of T cells in recovery from severe a
Externí odkaz:
https://doaj.org/article/65f5955351984f9f865c72eabf9ac06e
Autor:
Elaine Haddock, Julie Callison, Stephanie N. Seifert, Atsushi Okumura, Tsing-Lee Tang-Huau, Shanna S. Leventhal, Matthew C. Lewis, Jamie Lovaglio, Patrick W. Hanley, Carl Shaia, David W. Hawman, Vincent J. Munster, Michael A. Jarvis, Juergen A. Richt, Heinz Feldmann
Publikováno v:
Microorganisms, Vol 10, Iss 2, p 407 (2022)
As the COVID-19 pandemic moves into its third year, there remains a need for additional animal models better recapitulating severe COVID to study SARS-CoV-2 pathogenesis and develop countermeasures, especially treatment options. Pigs are known interm
Externí odkaz:
https://doaj.org/article/1b66dc7f494143b1a4ff50a070268234
Autor:
James Duehr, Meagan McMahon, Brandi Williamson, Fatima Amanat, Alan Durbin, David W. Hawman, Danny Noack, Skyler Uhl, Gene S. Tan, Heinz Feldmann, Florian Krammer
Publikováno v:
mBio, Vol 11, Iss 2 (2020)
ABSTRACT Hantaviruses are the etiological agent of hemorrhagic fever with renal syndrome (HFRS) and hantavirus cardiopulmonary syndrome (HCPS). The latter is associated with case fatality rates ranging from 30% to 50%. HCPS cases are rare, with appro
Externí odkaz:
https://doaj.org/article/a07b27d030d04b76a86ce12028632023