Zobrazeno 1 - 10
of 471
pro vyhledávání: '"David W Ellison"'
Autor:
Quynh T. Tran, Alex Breuer, Tong Lin, Ruth Tatevossian, Sariah J. Allen, Michael Clay, Larissa V. Furtado, Mark Chen, Dale Hedges, Tylman Michael, Giles Robinson, Paul Northcott, Amar Gajjar, Elizabeth Azzato, Sheila Shurtleff, David W. Ellison, Stanley Pounds, Brent A. Orr
Publikováno v:
npj Precision Oncology, Vol 8, Iss 1, Pp 1-12 (2024)
Abstract As part of the advancement in therapeutic decision-making for brain tumor patients at St. Jude Children’s Research Hospital (SJCRH), we developed three robust classifiers, a deep learning neural network (NN), k-nearest neighbor (kNN), and
Externí odkaz:
https://doaj.org/article/04b24c66871347abb0fb60d227703a96
Autor:
Julieann C. Lee, Selene C. Koo, Larissa V. Furtado, Alex Breuer, Mohammad K. Eldomery, Asim K. Bag, Pat Stow, Gary Rose, Trisha Larkin, Rick Sances, Bette K. Kleinschmidt-DeMasters, Jenna L. Bodmer, Nicholas Willard, Murat Gokden, Sonika Dahiya, Kaleigh Roberts, Kelsey C. Bertrand, Daniel C. Moreira, Giles W. Robinson, Jun Qin Mo, David W. Ellison, Brent A. Orr
Publikováno v:
Acta Neuropathologica Communications, Vol 12, Iss 1, Pp 1-14 (2024)
Abstract Neuroepithelial tumors with fusion of PLAGL1 or amplification of PLAGL1/PLAGL2 have recently been described often with ependymoma-like or embryonal histology respectively. To further evaluate emerging entities with PLAG-family genetic altera
Externí odkaz:
https://doaj.org/article/010d827f4cd9482a8210e6cd47d6e696
Autor:
Yasmine A. Valentin-Vega, Yong-Dong Wang, Matthew Parker, Deanna M. Patmore, Anderson Kanagaraj, Jennifer Moore, Michael Rusch, David Finkelstein, David W. Ellison, Richard J. Gilbertson, Jinghui Zhang, Hong Joo Kim, J. Paul Taylor
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-3 (2024)
Externí odkaz:
https://doaj.org/article/2e6b3753624f496fa1688dfcc00ce983
Autor:
Jo Meagan Garner, David W Ellison, David Finkelstein, Debolina Ganguly, Ziyun Du, Michelle Sims, Chuan He Yang, Rodrigo B Interiano, Andrew M Davidoff, Lawrence M Pfeffer
Publikováno v:
PLoS ONE, Vol 10, Iss 12, p e0145052 (2015)
[This corrects the article DOI: 10.1371/journal.pone.0125838.].
Externí odkaz:
https://doaj.org/article/4005f6d2dd6144caac3c875c6fd92903
Autor:
Jo Meagan Garner, David W Ellison, David Finkelstein, Debolina Ganguly, Ziyun Du, Michelle Sims, Chuan He Yang, Rodrigo B Interiano, Andrew M Davidoff, Lawrence M Pfeffer
Publikováno v:
PLoS ONE, Vol 10, Iss 5, p e0125838 (2015)
Malignant glioblastoma (GBM) is a highly aggressive brain tumor with a dismal prognosis and limited therapeutic options. Genomic profiling of GBM samples has identified four molecular subtypes (Proneural, Neural, Classical and Mesenchymal), which may
Externí odkaz:
https://doaj.org/article/3e1b959d254b4258a12fcead3ad95b12
Autor:
Ibrahim eQaddoumi, Mehmet eKocak, Atmaram S. Pai-Panandiker, Gregory T. Armstrong, Cynthia eWetmore, John R. Crawford, Tong eLin, James M Boyett, Larry E. Kun, Fredrick A. Boop, Thomas E. Merchant, David W Ellison, Amar eGajjar, Alberto eBroniscer
Publikováno v:
Frontiers in Oncology, Vol 4 (2014)
Background. Epidermal growth factor receptor is overexpressed in most pediatric high-grade gliomas (HGG). Since erlotinib had shown activity in adults with HGG, we conducted a phase II trial of erlotinib and local radiotherapy in children with newly
Externí odkaz:
https://doaj.org/article/102abc8e336441c8bd6189bc470514b0
Autor:
Yuan Lu, Sarra L Ryan, David J Elliott, Graham R Bignell, P Andrew Futreal, David W Ellison, Simon Bailey, Steven C Clifford
Publikováno v:
PLoS ONE, Vol 4, Iss 7, p e6159 (2009)
Medulloblastoma is the most common malignant brain tumour of childhood. The identification of critical genes involved in its pathogenesis will be central to advances in our understanding of its molecular basis, and the development of improved therape
Externí odkaz:
https://doaj.org/article/b41022fe00cc4ec689320bfc476e8694
Autor:
Michael Rusch, Joy Nakitandwe, Sheila Shurtleff, Scott Newman, Zhaojie Zhang, Michael N. Edmonson, Matthew Parker, Yuannian Jiao, Xiaotu Ma, Yanling Liu, Jiali Gu, Michael F. Walsh, Jared Becksfort, Andrew Thrasher, Yongjin Li, James McMurry, Erin Hedlund, Aman Patel, John Easton, Donald Yergeau, Bhavin Vadodaria, Ruth G. Tatevossian, Susana Raimondi, Dale Hedges, Xiang Chen, Kohei Hagiwara, Rose McGee, Giles W. Robinson, Jeffery M. Klco, Tanja A. Gruber, David W. Ellison, James R Downing, Jinghui Zhang
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
Clinical oncology is rapidly adopting next-generation sequencing technology for nucleotide variant and indel detection. Here the authors present a three-platform approach (whole-genome, whole-exome, and whole-transcriptome) in pediatric patients for
Externí odkaz:
https://doaj.org/article/70098f25f1d6428b99342a75e0d3ce05
Autor:
Liam D. Hendrikse, Parthiv Haldipur, Olivier Saulnier, Jake Millman, Alexandria H. Sjoboen, Anders W. Erickson, Winnie Ong, Victor Gordon, Ludivine Coudière-Morrison, Audrey L. Mercier, Mohammad Shokouhian, Raúl A. Suárez, Michelle Ly, Stephanie Borlase, David S. Scott, Maria C. Vladoiu, Hamza Farooq, Olga Sirbu, Takuma Nakashima, Shohei Nambu, Yusuke Funakoshi, Alec Bahcheli, J. Javier Diaz-Mejia, Joseph Golser, Kathleen Bach, Tram Phuong-Bao, Patryk Skowron, Evan Y. Wang, Sachin A. Kumar, Polina Balin, Abhirami Visvanathan, John J. Y. Lee, Ramy Ayoub, Xin Chen, Xiaodi Chen, Karen L. Mungall, Betty Luu, Pierre Bérubé, Yu C. Wang, Stefan M. Pfister, Seung-Ki Kim, Olivier Delattre, Franck Bourdeaut, François Doz, Julien Masliah-Planchon, Wieslawa A. Grajkowska, James Loukides, Peter Dirks, Michelle Fèvre-Montange, Anne Jouvet, Pim J. French, Johan M. Kros, Karel Zitterbart, Swneke D. Bailey, Charles G. Eberhart, Amulya A. N. Rao, Caterina Giannini, James M. Olson, Miklós Garami, Peter Hauser, Joanna J. Phillips, Young S. Ra, Carmen de Torres, Jaume Mora, Kay K. W. Li, Ho-Keung Ng, Wai S. Poon, Ian F. Pollack, Enrique López-Aguilar, G. Yancey Gillespie, Timothy E. Van Meter, Tomoko Shofuda, Rajeev Vibhakar, Reid C. Thompson, Michael K. Cooper, Joshua B. Rubin, Toshihiro Kumabe, Shin Jung, Boleslaw Lach, Achille Iolascon, Veronica Ferrucci, Pasqualino de Antonellis, Massimo Zollo, Giuseppe Cinalli, Shenandoah Robinson, Duncan S. Stearns, Erwin G. Van Meir, Paola Porrati, Gaetano Finocchiaro, Maura Massimino, Carlos G. Carlotti, Claudia C. Faria, Martine F. Roussel, Frederick Boop, Jennifer A. Chan, Kimberly A. Aldinger, Ferechte Razavi, Evelina Silvestri, Roger E. McLendon, Eric M. Thompson, Marc Ansari, Maria L. Garre, Fernando Chico, Pilar Eguía, Mario Pérezpeña, A. Sorana Morrissy, Florence M. G. Cavalli, Xiaochong Wu, Craig Daniels, Jeremy N. Rich, Steven J. M. Jones, Richard A. Moore, Marco A. Marra, Xi Huang, Jüri Reimand, Poul H. Sorensen, Robert J. Wechsler-Reya, William A. Weiss, Trevor J. Pugh, Livia Garzia, Claudia L. Kleinman, Lincoln D. Stein, Nada Jabado, David Malkin, Olivier Ayrault, Jeffrey A. Golden, David W. Ellison, Brad Doble, Vijay Ramaswamy, Tamra E. Werbowetski-Ogilvie, Hiromichi Suzuki, Kathleen J. Millen, Michael D. Taylor
Publikováno v:
Nature, 609(7929), 1021-1028. Nature Publishing Group
Nature
Nature
Medulloblastoma (MB) comprises a group of heterogeneous paediatric embryonal neoplasms of the hindbrain with strong links to early development of the hindbrain 1–4. Mutations that activate Sonic hedgehog signalling lead to Sonic hedgehog MB in the
Autor:
Anthony P. Y. Liu, Sandeep K. Dhanda, Tong Lin, Edgar Sioson, Aksana Vasilyeva, Brian Gudenas, Ruth G. Tatevossian, Sujuan Jia, Geoffrey Neale, Daniel C. Bowers, Tim Hassall, Sonia Partap, John R. Crawford, Murali Chintagumpala, Eric Bouffet, Geoff McCowage, Alberto Broniscer, Ibrahim Qaddoumi, Greg Armstrong, Karen D. Wright, Santhosh A. Upadhyaya, Anna Vinitsky, Christopher L. Tinkle, John Lucas, Jason Chiang, Daniel J. Indelicato, Robert Sanders, Paul Klimo, Frederick A. Boop, Thomas E. Merchant, David W. Ellison, Paul A. Northcott, Brent A. Orr, Xin Zhou, Arzu Onar-Thomas, Amar Gajjar, Giles W. Robinson
Publikováno v:
Acta Neuropathologica. 144:733-746
Methylation profiling has radically transformed our understanding of tumors previously called central nervous system primitive neuro-ectodermal tumors (CNS-PNET). While this marks a momentous step toward defining key differences, reclassification has