Zobrazeno 1 - 10
of 33
pro vyhledávání: '"David W Colby"'
Autor:
Hilda Mirbaha, Dailu Chen, Olga A Morazova, Kiersten M Ruff, Apurwa M Sharma, Xiaohua Liu, Mohammad Goodarzi, Rohit V Pappu, David W Colby, Hamid Mirzaei, Lukasz A Joachimiak, Marc I Diamond
Publikováno v:
eLife, Vol 7 (2018)
Tauopathies feature progressive accumulation of tau amyloids. Pathology may begin when these amplify from a protein template, or seed, whose structure is unknown. We have purified and characterized distinct forms of tau monomer—inert (Mi) and seed-
Externí odkaz:
https://doaj.org/article/4a281ab9d29a4287a093526308f4f1c5
Autor:
Bei Wu, Alex J McDonald, Kathleen Markham, Celeste B Rich, Kyle P McHugh, Jörg Tatzelt, David W Colby, Glenn L Millhauser, David A Harris
Publikováno v:
eLife, Vol 6 (2017)
PrPC, the cellular isoform of the prion protein, serves to transduce the neurotoxic effects of PrPSc, the infectious isoform, but how this occurs is mysterious. Here, using a combination of electrophysiological, cellular, and biophysical techniques,
Externí odkaz:
https://doaj.org/article/e25aea8ab81e414abac02e864afe08be
Autor:
David W Colby, Rachel Wain, Ilia V Baskakov, Giuseppe Legname, Christina G Palmer, Hoang-Oanh B Nguyen, Azucena Lemus, Fred E Cohen, Stephen J DeArmond, Stanley B Prusiner
Publikováno v:
PLoS Pathogens, Vol 6, Iss 1, p e1000736 (2010)
Prions arise when the cellular prion protein (PrP(C)) undergoes a self-propagating conformational change; the resulting infectious conformer is designated PrP(Sc). Frequently, PrP(Sc) is protease-resistant but protease-sensitive (s) prions have been
Externí odkaz:
https://doaj.org/article/05d2fdbcce8f465787a434786e853dd7
Publikováno v:
Biomaterials Science. 6:1358-1370
Induced pluripotent stem cells (iPSCs) are of interest for the study of disease, where these cells can be derived from patients and have the potential to be differentiated into any cell type; however, three-dimensional (3D) culture and differentiatio
Autor:
Kiersten M. Ruff, Hilda Mirbaha, David W. Colby, Hamid Mirzaei, Mohammad Goodarzi, Rohit V. Pappu, Xiaohua Liu, Olga A. Morozova, Marc I. Diamond, Dailu Chen, Lukasz A. Joachimiak, Apurwa M Sharma
Publikováno v:
eLife, Vol 7 (2018)
eLife
eLife
Tauopathies feature progressive accumulation of tau amyloids. Pathology may begin when these amplify from a protein template, or seed, whose structure is unknown. We have purified and characterized distinct forms of tau monomer—inert (Mi) and seed-
Autor:
Dailu Chen, Lukasz A. Joachimiak, Xiaohua Liu, Apurwa M Sharma, Kiersten M. Ruff, Olga A Morazova, Rohit V. Pappu, Marc I. Diamond, Hilda Mirbaha, Mohammad Goodarzi, David W. Colby, Hamid Mirzaei
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ecf97c27def13d8ec2ec8bb2d7360b45
https://doi.org/10.7554/elife.36584.035
https://doi.org/10.7554/elife.36584.035
Autor:
David W. Colby, Kyle M. Doolan
Publikováno v:
Journal of Molecular Biology. 427:328-340
Prion diseases are caused by a structural rearrangement of the cellular prion protein, PrP(C), into a disease-associated conformation, PrP(Sc), which may be distinguished from one another using conformation-specific antibodies. We used mutational sca
Autor:
Hilda Mirbaha, Lukasz A. Joachimiak, Apurwa M Sharma, Xiaohua Liu, Olga A. Morozova, Hamid Mirzaei, Dailu Chen, Kiersten M. Ruff, Rohit V. Pappu, David W. Colby, Marc I. Diamond
Tauopathies feature progressive accumulation of tau amyloids. Pathology may begin when these amplify from a protein template, or seed, whose structure is unknown. We have purified and characterized distinct forms of tau monomer—inert (Mi) and seed-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d668420f9109dda0864cf8e8b851b9d7
https://doi.org/10.1101/163394
https://doi.org/10.1101/163394
Autor:
Glenn L. Millhauser, Jörg Tatzelt, David W. Colby, Kyle P McHugh, David A. Harris, Celeste B. Rich, Kathleen Markham, Bei Wu, Alex J. McDonald
Publikováno v:
eLife
eLife, Vol 6 (2017)
eLife, Vol 6 (2017)
PrPC, the cellular isoform of the prion protein, serves to transduce the neurotoxic effects of PrPSc, the infectious isoform, but how this occurs is mysterious. Here, using a combination of electrophysiological, cellular, and biophysical techniques,
Author response: The N-terminus of the prion protein is a toxic effector regulated by the C-terminus
Autor:
David A. Harris, Alex J. McDonald, Celeste B. Rich, David W. Colby, Jörg Tatzelt, Kyle P McHugh, Glenn L. Millhauser, Bei Wu, Kathleen Markham
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fbe3148b925ab288276f385f424b7e86
https://doi.org/10.7554/elife.23473.028
https://doi.org/10.7554/elife.23473.028