Zobrazeno 1 - 10
of 75
pro vyhledávání: '"David W A Bourne"'
Autor:
Alireza (Allen) Ghaffari, Brock A. Matter, Rachel R. Hartman, David W. A. Bourne, Yan Wang, Stephanie Choi, Uday B. Kompella
Publikováno v:
Pharmaceutics, Vol 16, Iss 7, p 895 (2024)
Developing bioequivalent (BE) generic products of complex dosage forms like intravitreal implants (IVIs) of corticosteroids such as dexamethasone prepared using hot-melt extrusion (HME), based on biodegradable poly (lactide-co-glycolide) (PLGA) polym
Externí odkaz:
https://doaj.org/article/fe2c7f17f5564f3ea69a8850b4e81a40
Autor:
Uday B. Kompella, Jiban Jyoti Panda, Stephanie Choi, David W. A. Bourne, Sunil K. Vooturi, Sarath Yandrapu, Hyewon Kim
Publikováno v:
J Ocul Pharmacol Ther
PURPOSE: To determine the effect of particle size and viscosity of suspensions on topical ocular bioavailability of budesonide, a corticosteroid drug. METHODS: Budesonide microparticle and nanoparticle (MP and NP) suspensions were prepared with or wi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f4631a1a5596365b3233cd107bc1089
https://doi.org/10.1089/jop.2019.0150
https://doi.org/10.1089/jop.2019.0150
Publikováno v:
AAPS PharmSciTech. 23(6)
The purpose of this study was to develop a validated LC-MS/MS analytical method for the simultaneous analysis of a large cassette containing a wide range of drug substances with positive, negative, or neutral charge and further apply the method to as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::90d13fea832609b45da8684a64874df0
https://pubmed.ncbi.nlm.nih.gov/35819539
https://pubmed.ncbi.nlm.nih.gov/35819539
Autor:
Madhoosudan A. Patil, Brock A. Matter, Yogendra H. Raol, David W. A. Bourne, Ryan A. Kelley, Uday B. Kompella
Publikováno v:
Pharmaceutics, Vol 10, Iss 4, p 281 (2018)
Flupirtine, a nonopioid analgesic drug, is effective in treating neonatal seizures. However, its brain delivery and pharmacokinetics are unknown in neonatal mammals. The purpose of this study was to determine the pharmacokinetics of flupirtine and th
Externí odkaz:
https://doaj.org/article/70f65b48e3a043f38c71786e67e4956e
Autor:
Cristina Sempio, Erica Wymore, David W. A. Bourne, Torri D. Metz, George Sam Wang, Maya Bunik, Claire Palmer
Publikováno v:
JAMA Pediatr
This cohort study measures Δ-9-tetrahydrocannabinol levels in breast milk and serum samples from women who were newly abstinent from marijuana and had just delivered an infant.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ddfb58b544aa48e8fb71e42d7903c50
https://pubmed.ncbi.nlm.nih.gov/33683306
https://pubmed.ncbi.nlm.nih.gov/33683306
Autor:
Sukyung Woo, Teresa V. Lewis, David W A Bourne, Sin Yin Lim, Pornpimol Rianthavorn, Michael E. Burton, Martin A. Turman
Publikováno v:
J Pediatr Pharmacol Ther
BACKGROUNDChildren who undergo hemodialysis (HD) and peritoneal dialysis are at increased risk of infection. Daptomcyin is used to treat resistant infections; however, the pharmacokinetics of daptomycin in pediatric and adolescent dialysis patients r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9457bca5512850e83a67604cd630bad4
https://europepmc.org/articles/PMC7887886/
https://europepmc.org/articles/PMC7887886/
Autor:
Jost Klawitter, Kennon Heard, Laura M. Borgelt, Kelly G. Knupp, David W. A. Bourne, Jan Leonard, Uwe Christians, George Sam Wang, Michael F. Wempe, Cristina Sempio, Kevin E. Chapman, Lalit Bajaj
Publikováno v:
Clinical pharmacokinetics. 59(8)
Despite limited evidence, cannabidiol-rich cannabis extracts have been popularly used in pediatrics. With increased use, it is critical to determine basic pharmacokinetic parameters of cannabidiol in these extracts in the pediatric population. The ob
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bfb78cb10f72ae2d450917fe1c22d0a3
https://pubmed.ncbi.nlm.nih.gov/32048179
https://pubmed.ncbi.nlm.nih.gov/32048179
Autor:
David W. A. Bourne, Guankui Wang, Vivian P. Vu, Weston J. Smith, Hanmant Gaikwad, Dmitri Simberg, Ernest Groman
Publikováno v:
ACS Nano. 12:12523-12532
Long blood half-life is one of the advantages of antibodies over small molecule drugs. At the same time, prolonged half-life is a problem for imaging applications or in the case of antibody-induced toxicities. There is a substantial need for antidote
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5810fe9be2865f1ad95ea6c72fe79e07
https://doi.org/10.1021/acsnano.8b07003
https://doi.org/10.1021/acsnano.8b07003
Autor:
Jeffrey L. Galinkin, Jon Kaufman, Benjamin H. Goot, Francis Hickey, Eduardo da Cruz, Zhaoxing Pan, Jeannie Zuk, David W. A. Bourne, Uwe Christians, Mark D. Twite
Publikováno v:
Pediatric Critical Care Medicine. 19:459-467
Objectives To assess if morphine pharmacokinetics are different in children with Down syndrome when compared with children without Down syndrome. Design Prospective single-center study including subjects with Down syndrome undergoing cardiac surgery
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ed0e485388c81cbeadaacedbdca2f05
https://doi.org/10.1097/pcc.0000000000001537
https://doi.org/10.1097/pcc.0000000000001537
Autor:
David W. A. Bourne, Sarah A. Mellion, Joseph Wathen, Kathleen Adelgais, Jeffrey L. Galinkin, Alison Brent, Lina Brou
Publikováno v:
The Journal of Emergency Medicine. 53:397-404
Atomized intranasal midazolam is a common adjunct in pediatrics for procedural anxiolysis. There are no previous studies of validated anxiety scores with pharmacokinetic data to support optimal procedure timing.We describe the clinical and pharmacoki
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5bc4f1aab197c931ded4090cfc65bbfc
https://doi.org/10.1016/j.jemermed.2017.05.029
https://doi.org/10.1016/j.jemermed.2017.05.029