Zobrazeno 1 - 10
of 254
pro vyhledávání: '"David W, Ray"'
Autor:
Junxi Liu, Rebecca C. Richmond, Emma L. Anderson, Jack Bowden, Ciarrah-Jane S. Barry, Hassan S. Dashti, Iyas S. Daghlas, Jacqueline M. Lane, Simon D. Kyle, Céline Vetter, Claire L. Morrison, Samuel E. Jones, Andrew R. Wood, Timothy M. Frayling, Alison K. Wright, Matthew J. Carr, Simon G. Anderson, Richard A. Emsley, David W. Ray, Michael N. Weedon, Richa Saxena, Martin K. Rutter, Deborah A. Lawlor
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-14 (2024)
Abstract Self-reported shorter/longer sleep duration, insomnia, and evening preference are associated with hyperglycaemia in observational analyses, with similar observations in small studies using accelerometer-derived sleep traits. Mendelian random
Externí odkaz:
https://doaj.org/article/7570bd5e2c7049fda1219de8ef4b9840
Autor:
Hang Yuan, Tatiana Plekhanova, Rosemary Walmsley, Amy C. Reynolds, Kathleen J. Maddison, Maja Bucan, Philip Gehrman, Alex Rowlands, David W. Ray, Derrick Bennett, Joanne McVeigh, Leon Straker, Peter Eastwood, Simon D. Kyle, Aiden Doherty
Publikováno v:
npj Digital Medicine, Vol 7, Iss 1, Pp 1-10 (2024)
Abstract Sleep is essential to life. Accurate measurement and classification of sleep/wake and sleep stages is important in clinical studies for sleep disorder diagnoses and in the interpretation of data from consumer devices for monitoring physical
Externí odkaz:
https://doaj.org/article/36ffd372308e479ea4a5dd8446781704
Publikováno v:
Open Biology, Vol 14, Iss 7 (2024)
Rheumatoid arthritis is a chronic inflammatory disease that shows characteristic diurnal variation in symptom severity, where joint resident fibroblast-like synoviocytes (FLS) act as important mediators of arthritis pathology. We investigate the role
Externí odkaz:
https://doaj.org/article/66b3aadbc6b24d708c7eb5a389aa1c52
Publikováno v:
Endocrine Connections, Vol 13, Iss 2, Pp 1-8 (2024)
Background and aims: Non-alcoholic fatty liver disease (NAFLD) has rapidly become the most common liver disease worldwide. Modern lifestyles have been linked to this rise in prevalence with changes in rhythmic human behaviour emerging as a possible m
Externí odkaz:
https://doaj.org/article/666be81a027c4c0c9bffd56ca548887b
Autor:
Federica Cuozzo, Katrina Viloria, Ali H. Shilleh, Daniela Nasteska, Charlotte Frazer-Morris, Jason Tong, Zicong Jiao, Adam Boufersaoui, Bryan Marzullo, Daniel B. Rosoff, Hannah R. Smith, Caroline Bonner, Julie Kerr-Conte, Francois Pattou, Rita Nano, Lorenzo Piemonti, Paul R.V. Johnson, Rebecca Spiers, Jennie Roberts, Gareth G. Lavery, Anne Clark, Carlo D.L. Ceresa, David W. Ray, Leanne Hodson, Amy P. Davies, Guy A. Rutter, Masaya Oshima, Raphaël Scharfmann, Matthew J. Merrins, Ildem Akerman, Daniel A. Tennant, Christian Ludwig, David J. Hodson
Publikováno v:
Cell Reports, Vol 43, Iss 4, Pp 114047- (2024)
Summary: Using 13C6 glucose labeling coupled to gas chromatography-mass spectrometry and 2D 1H-13C heteronuclear single quantum coherence NMR spectroscopy, we have obtained a comparative high-resolution map of glucose fate underpinning β cell functi
Externí odkaz:
https://doaj.org/article/2e924f2360b54e9dbc6f6da13e566a04
Autor:
Hang Yuan, Tatiana Plekhanova, Rosemary Walmsley, Amy C. Reynolds, Kathleen J. Maddison, Maja Bucan, Philip Gehrman, Alex Rowlands, David W. Ray, Derrick Bennett, Joanne McVeigh, Leon Straker, Peter Eastwood, Simon D. Kyle, Aiden Doherty
Publikováno v:
npj Digital Medicine, Vol 7, Iss 1, Pp 1-1 (2024)
Externí odkaz:
https://doaj.org/article/f4e70a730cf045469f65a5d4053d739f
Autor:
Karolina Krakowiak, Robert J. Maidstone, Amlan Chakraborty, Alexandra C. Kendall, Anna Nicolaou, Polly Downton, Andreea-Daniela Cristian, Dave Singh, Andrew S.I. Loudon, David W. Ray, Hannah J. Durrington
Publikováno v:
ERJ Open Research, Vol 9, Iss 4 (2023)
Rationale Asthma is a rhythmic inflammatory disease of the airway, regulated by the circadian clock. “Spill-over” of airway inflammation into the systemic circulation occurs in asthma and is reflected in circulating immune cell repertoire. The ob
Externí odkaz:
https://doaj.org/article/0337552d37bf43aa97bf1cfd901273bb
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Vaccination, as a public health measure, offers effective protection of populations against infectious diseases. Optimising vaccination efficacy, particularly for higher-risk individuals, like the elderly whose immunocompromised state can prevent the
Externí odkaz:
https://doaj.org/article/bae7e231a4d44fac91de830f843fa625
Autor:
Shilpa R. Nagarajan, Eloise Cross, Elspeth Johnson, Fabio Sanna, Lorna J. Daniels, David W. Ray, Leanne Hodson
Publikováno v:
Physiological Reports, Vol 10, Iss 20, Pp n/a-n/a (2022)
Abstract Pathological accumulation of intrahepatic triglyceride underpins the early stages of nonalcoholic fatty liver disease (NAFLD) and can progress to fibrosis, cirrhosis, and cancer of the liver. Studies in humans suggest that consumption of a d
Externí odkaz:
https://doaj.org/article/fae4db7949804a69a57ac45bd376de0f
Autor:
Xiaodong Zhuang, Donall Forde, Senko Tsukuda, Valentina D’Arienzo, Laurent Mailly, James M. Harris, Peter A. C. Wing, Helene Borrmann, Mirjam Schilling, Andrea Magri, Claudia Orbegozo Rubio, Robert J. Maidstone, Mudassar Iqbal, Miguel Garzon, Rosalba Minisini, Mario Pirisi, Sam Butterworth, Peter Balfe, David W. Ray, Koichi Watashi, Thomas F. Baumert, Jane A. McKeating
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
The circadian factors BMAL1/CLOCK and REV-ERB are master regulators of the human liver transcriptome but their role in hepatitis B virus infection is largely unknown. Here, Zhuang et al. show that REV-ERB regulates hepatitis B virus entry and BMAL1 d
Externí odkaz:
https://doaj.org/article/6a8ef38d436d4d3fbb7a5a30aa9a40f8