Zobrazeno 1 - 10
of 116
pro vyhledávání: '"David W, Melton"'
Autor:
Ricardo Ramirez, Allen Michael Herrera, Joshua Ramirez, Chunjiang Qian, David W. Melton, Paula K. Shireman, Yu-Fang Jin
Publikováno v:
BMC Bioinformatics, Vol 20, Iss 1, Pp 1-23 (2019)
Abstract Background Macrophages show versatile functions in innate immunity, infectious diseases, and progression of cancers and cardiovascular diseases. These versatile functions of macrophages are conducted by different macrophage phenotypes classi
Externí odkaz:
https://doaj.org/article/a22261ab78534568921f3561c4c7dac6
Autor:
Liang Song, Ewan M. McNeil, Ann-Marie Ritchie, Katy R. Astell, Charlie Gourley, David W. Melton
Publikováno v:
BMC Cancer, Vol 17, Iss 1, Pp 1-14 (2017)
Abstract Background The global incidence of melanoma has been increasing faster than any other form of cancer. New therapies offer exciting prospects for improved survival, but the development of resistance is a major problem and there remains a need
Externí odkaz:
https://doaj.org/article/7ad027d6ba824e33a5c51694505d0868
Autor:
David W. Melton
Publikováno v:
Gene Cloning and Analysis ISBN: 9781003421474
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7a656b35eb5e6b4d23c46ea62c247cc9
https://doi.org/10.1201/9781003421474-10
https://doi.org/10.1201/9781003421474-10
Autor:
Carlota Colomer, Miriam K Gomez, David W. Melton, Mark J. O'Connor, Elisabetta Leo, Michael Churchman, Charlie Gourley, Giuditta Illuzzi, Robert L Hollis
Publikováno v:
Cancers
Cancers, Vol 12, Iss 1503, p 1503 (2020)
Volume 12
Issue 6
Cancers, Vol 12, Iss 1503, p 1503 (2020)
Volume 12
Issue 6
High grade serous ovarian cancer (HGSOC) is a major cause of female cancer mortality. The approval of poly (ADP-ribose) polymerase (PARP) inhibitors for clinical use has greatly improved treatment options for patients with homologous recombination re
Autor:
Allen Michael Herrera, Paula K. Shireman, Joshua Ramirez, Ricardo Ramirez, Yufang Jin, David W. Melton, Chunjiang Qian
Publikováno v:
BMC Bioinformatics, Vol 20, Iss 1, Pp 1-23 (2019)
BMC Bioinformatics
BMC Bioinformatics
BackgroundMacrophages show versatile functions in innate immunity, infectious diseases, and progression of cancers and cardiovascular diseases. These versatile functions of macrophages are conducted by different macrophage phenotypes classified as cl
Autor:
Catriona Paul, Joanne E Povey, Nicola J Lawrence, Jim Selfridge, David W Melton, Philippa T K Saunders
Publikováno v:
PLoS ONE, Vol 2, Iss 10, p e989 (2007)
BACKGROUND:Infertility affects approximately 20% of couples in Europe and in 50% of cases the problem lies with the male partner. The impact of damaged DNA originating in the male germ line on infertility is poorly understood but may increase miscarr
Externí odkaz:
https://doaj.org/article/14b57c3ec4c547e9b833ede6e287e1db
Publikováno v:
Oncotarget
Yang, L, Ritchie, A-M & Melton, D 2017, ' Disruption of DNA repair in cancer cells by ubiquitination of a destabilising dimerization domain of nucleotide excision repair protein ERCC1 ', Oncotarget . https://doi.org/10.18632/oncotarget.19422
Yang, L, Ritchie, A-M & Melton, D 2017, ' Disruption of DNA repair in cancer cells by ubiquitination of a destabilising dimerization domain of nucleotide excision repair protein ERCC1 ', Oncotarget . https://doi.org/10.18632/oncotarget.19422
// Lanlan Yang 1 , Ann-Marie Ritchie 1 and David W. Melton 1 1 Edinburgh Cancer Research Centre, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, EH4 2XU, UK Correspondence to: David W. M
Autor:
Janet Brownlees, David W. Melton, Timothy M. Chapman, Puneet Khurana, Emilie A. Bureau, Simon Fox, Claire Wallace, Preeti Bakrania, P.J. Coombs, Kevin J. Gillen, Barbara Saxty
Publikováno v:
Chapman, T M, Wallace, C, Gillen, K J, Bakrania, P, Khurana, P, Coombs, P J, Fox, S, Bureau, E A, Brownlees, J, Melton, D & Saxty, B 2015, ' N-Hydroxyimides and hydroxypyrimidinones as inhibitors of the DNA repair complex ERCC1-XPF ', Bioorganic & Medicinal Chemistry Letters, vol. 25, no. 19 . https://doi.org/doi:10.1016/j.bmcl.2015.08.024
A high throughput screen allowed the identification of N-hydroxyimide inhibitors of ERCC1-XPF endonuclease activity with micromolar potency, but they showed undesirable selectivity profiles against FEN-1. A scaffold hop to a hydroxypyrimidinone templ
Autor:
David W. Melton, Douglas R. Houston, Preeti Bakrania, Martin A. Wear, Barbara Saxty, Ann Marie Ritchie, Steven Shave, Tim Chapman, Katy R. Astell, Puneet Khurana, Claire Wallace, Ewan M. McNeil, Malcolm D. Walkinshaw, Hayley M. Jones
Publikováno v:
McNeil, E M, Astell, K R, Ritchie, A-M, Shave, S, Houston, D R, Bakrania, P, Jones, H M, Khurana, P, Wallace, C, Chapman, T, Wear, M A, Walkinshaw, M D, Saxty, B & Melton, D W 2015, ' Inhibition of the ERCC1-XPF structure-specific endonuclease to overcome cancer chemoresistance ', DNA Repair, vol. 31, pp. 19-28 . https://doi.org/10.1016/j.dnarep.2015.04.002
ERCC1-XPF is a structure-specific endonuclease that is required for the repair of DNA lesions, generated by the widely used platinum-containing cancer chemotherapeutics such as cisplatin, through the Nucleotide Excision Repair and Interstrand Crossli
Autor:
William J. Faller, Yafeng Ma, Laura M. Machesky, Tamasin Doig, Owen J. Sansom, David W. Melton, Ewan Brown
Publikováno v:
Melanoma Research. 25:169-172
Levels of the actin bundling protein fascin correlate with invasion and metastasis and reveal prognostic value in many epithelial carcinomas. However, we know very little about the potential role of fascin in melanoma. The purpose of this study is to