Výsledky vyhledávání - "David W, Hedley"

Akademický článek

Digital quantitative tissue image analysis of hypoxia in resected pancreatic ductal adenocarcinomas

Autor: Iram Siddiqui, Jade Bilkey, Trevor D. McKee, Stefano Serra, Melania Pintilie, Trevor Do, Jing Xu, Ming-Sound Tsao, Steve Gallinger, Richard P. Hill, David W. Hedley, Neesha C. Dhani

Publikováno v: Frontiers in Oncology, Vol 12 (2022)

BackgroundTumor hypoxia is theorized to contribute to the aggressive biology of pancreatic ductal adenocarcinoma (PDAC). We previously reported that hypoxia correlated with rapid tumor growth and metastasis in patient-derived xenografts. Anticipating

Externí odkaz: https://doaj.org/article/5add2d3f4e1b40eaa01da29e4b140543

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Akademický článek

Patient-derived tumor xenograft and organoid models established from resected pancreatic, duodenal and biliary cancers

Publikováno v: Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)

Abstract Patient-derived xenograft (PDX) and their xenograft-derived organoid (XDO) models that recapitulate the genotypic and phenotypic landscape of patient cancers could help to advance research and lead to improved clinical management. PDX models

Externí odkaz: https://doaj.org/article/a748f950b73d4012ad6cf5ca93a0e308

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Akademický článek

Impact of tissue transport on PET hypoxia quantification in pancreatic tumours

Autor: Edward Taylor, Jennifer Gottwald, Ivan Yeung, Harald Keller, Michael Milosevic, Neesha C. Dhani, Iram Siddiqui, David W. Hedley, David A. Jaffray

Publikováno v: EJNMMI Research, Vol 7, Iss 1, Pp 1-11 (2017)

Abstract Background The clinical impact of hypoxia in solid tumours is indisputable and yet questions about the sensitivity of hypoxia-PET imaging have impeded its uptake into routine clinical practice. Notably, the binding rate of hypoxia-sensitive

Externí odkaz: https://doaj.org/article/1ad2da9298e04bdab497e42b4f29f338

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Pancreatic cancer growth promoted by bone marrow mesenchymal stromal cell–derived IL-6 is reversed predominantly by IL-6 blockade

Autor: Roula Antoon, Xing-Hua Wang, Amr H. Saleh, Jenny Warrington, David W Hedley, Armand Keating

Publikováno v: Cytotherapy. 24:699-710

Pancreatic cancer is a highly lethal cancer characterized by local invasiveness, early metastasis, recurrence and high resistance to current therapies. Extensive stroma or desmoplasia is a key histological feature of the disease, and interactions bet

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b7974fd9c887db9a16d180437e9e780
https://doi.org/10.1016/j.jcyt.2021.12.005

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Anal Adenocarcinoma: A Rare Entity in Need of Multidisciplinary Management

Autor: Carol J. Swallow, Amy ZhuHui Liu, Bernard Cummings, R. Wong, Alexandra M. Easson, Erin D. Kennedy, Monika K. Krzyzanowska, James D. Brierley, Fayez A. Quereshy, Eric Chen, John Kim, Aisling Barry, Jolie Ringash, Robert Gryfe, David W. Hedley, Laura A. Dawson, Ali Hosni, Jelena Lukovic

Publikováno v: Diseases of the Colon & Rectum. 65:189-197

Anal adenocarcinoma is a rare clinical entity for which the optimal management is not defined.This study aimed to describe the multidisciplinary management and outcomes of patients with anal adenocarcinoma.This is a retrospective cohort study.This st

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1cc421821ba3f0ebc68e06ca74fc4d0d
https://doi.org/10.1097/dcr.0000000000002281

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