Zobrazeno 1 - 10
of 54
pro vyhledávání: '"David W, Griggs"'
Autor:
Jubilee Ajiboye, José E. Teixeira, Makafui Gasonoo, Ethan B. Mattice, Bethany Korwin-Mihavics, Peter Miller, Alexandra C. Cameron, Erin Stebbins, Scott D. Campbell, David W. Griggs, Thomas Spangenberg, Marvin J. Meyers, Christopher D. Huston
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract Cryptosporidium parvum and C. hominis are parasites that cause life-threatening diarrhea in children and immunocompromised people. There is only one approved treatment that is modestly effective for children and ineffective for AIDS patients
Externí odkaz:
https://doaj.org/article/6b4fad2455a041379399a6eb6ce3f02b
Autor:
Jeannine Basta, Lynn Robbins, Lisa Stout, Michael J. Prinsen, David W. Griggs, Michael Rauchman
Publikováno v:
Physiological Reports, Vol 8, Iss 7, Pp n/a-n/a (2020)
Abstract Fibrosis is a final common pathway for many causes of progressive chronic kidney disease (CKD). Arginine–glycine–aspartic acid (RGD)‐binding integrins are important mediators of the pro‐fibrotic response by activating latent TGF‐β
Externí odkaz:
https://doaj.org/article/d341b803727d47eb838a4fef44f6b15e
Autor:
Ninecia R, Scott, Shyamala, Thirunavukkarasu, Javier, Rangel-Moreno, David W, Griggs, Shabaana A, Khader
Publikováno v:
Journal of interferoncytokine research : the official journal of the International Society for Interferon and Cytokine Research. 42(8)
Tuberculosis (TB) caused by the pathogenic bacterium
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::8183326cc073d33e692f9fe2326ce285
https://pubmed.ncbi.nlm.nih.gov/35914102
https://pubmed.ncbi.nlm.nih.gov/35914102
Autor:
Ninecia R. Scott, Shyamala Thirunavukkarasu, Javier Rangel-Moreno, David W. Griggs, Shabaana A. Khader
Publikováno v:
Journal of Interferon & Cytokine Research. 42:421-429
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::16f819fb8cc245579a24c876669d40ac
https://doi.org/10.1089/jir.2022.0027
https://doi.org/10.1089/jir.2022.0027
Autor:
Charles West, Connor Tobo, Jeffrey Au, David Johnson, M. Abdul Mottaleb, Jessica Robinson, Saloni Shringarpure, David W Griggs, Koyal Garg
Publikováno v:
American Journal of Physiology-Cell Physiology.
Volumetric muscle loss (VML) causes irrecoverable loss of muscle mass and strength and results in permanent disability. VML injury shows extensive fibrosis, which impedes functional tissue regeneration. Our lab has created a biosponge scaffold compos
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::89a4b2906c4fda2ff1bb07518cd4ad15
https://doi.org/10.1152/ajpcell.00092.2023
https://doi.org/10.1152/ajpcell.00092.2023
Inhibitors of Arg-Gly-Asp-Binding Integrins Reduce Development of Pancreatic Fibrosis in MiceSummary
Autor:
Barbara Ulmasov, Brent A. Neuschwander-Tetri, Jinping Lai, Vladimir Monastyrskiy, Trisha Bhat, Matthew P. Yates, Jonathan Oliva, Michael J. Prinsen, Peter G. Ruminski, David W. Griggs
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 2, Iss 4, Pp 499-518 (2016)
Background & Aims: Pancreatic stellate cells (PSCs) regulate the development of chronic pancreatitis (CP) and are activated by the cytokine transforming growth factor β (TGFB). Integrins of the αv family promote TGFB signaling in mice, probably
Externí odkaz:
https://doaj.org/article/9a6d1c0077404b55915eba3b895e7df1
Autor:
Erin Stebbins, Rajiv S Jumani, Connor Klopfer, John Barlow, Peter Miller, Mary A Campbell, Marvin J Meyers, David W Griggs, Christopher D Huston
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 12, Iss 1, p e0006183 (2018)
Cryptosporidiosis causes life-threatening diarrhea in infants, but the best available treatment is only modestly efficacious. Rodents infected with relevant Cryptosporidium species do not develop diarrhea, which complicates drug development. Cryptosp
Externí odkaz:
https://doaj.org/article/90a15caa07ba438c8f63d10b1b0ad766
Autor:
Maya Ezzo, Nuno M. Coelho, Stellar Boo, Sander van Putten, David W. Griggs, Boris Hinz, Christopher A. McCulloch, Nina Noskovičová, Ronen Schuster, Peter G. Ruminski, Anne Koehler
Publikováno v:
Nature Biomedical Engineering. 5:1437-1456
The fibrotic encapsulation of implants involves the mechanical activation of myofibroblasts and of pro-fibrotic transforming growth factor beta 1 (TGF-β1). Here, we show that both softening of the implant surfaces and inhibition of the activation of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::005d92d382f815aae7f280c7eb3f9ade
https://doi.org/10.1038/s41551-021-00722-z
https://doi.org/10.1038/s41551-021-00722-z
Autor:
David W. Griggs, Peter J. Miller, Marvin J. Meyers, Edmund Oboh, Christopher D. Huston, Tanner J Schubert, Haresh Thakellapalli, Jose E. Teixeira, Erin E. Stebbins, Scott D Campbell, Emily Philo
Publikováno v:
J Med Chem
Cryptosporidiosis is caused by infection of the small intestine by Cryptosporidium parasites, resulting in severe diarrhea, dehydration, malabsorption, and potentially death. The only FDA-approved therapeutic is only partially effective in young chil
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d773db3302967d1ddddfba8c787613c
https://europepmc.org/articles/PMC8792998/
https://europepmc.org/articles/PMC8792998/
Autor:
Leah Gehrs, Dwight M. Morrow, David W. Griggs, Stephanie Christ, Andreas Trumpp, Richard F. Heier, Eliza Wiercinska, Halvard Bonig, Moses O. Evbuomwan, Darja Karpova, Peter G. Ruminski, Julie Ritchey, Michael P. Rettig, Feng Gao, Daniel Cancilla, Ezhilarasi Chendamarai, Michael J. Prinsen, Hamza Celik, Grazia Abou-Ezzi, Daniel C. Link, John F. DiPersio, Marvin J. Meyers, Wei Yang, Stacy D. Arnett, Jingzhu Zhang, Matthew Holt, Linda Eissenberg
Publikováno v:
Journal of Clinical Investigation. 129:2745-2759
Mobilized peripheral blood has become the primary source of hematopoietic stem and progenitor cells (HSPCs) for stem cell transplantation, with a 5-day course of granulocyte colony-stimulating factor (G-CSF) as the most common regimen used for HSPC m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76508116b9efbe2c446f322074178732
https://doi.org/10.1172/jci124738
https://doi.org/10.1172/jci124738