Zobrazeno 1 - 10
of 81
pro vyhledávání: '"David W, Gray"'
Autor:
Maikel Izquierdo, De Lin, Sandra O'Neill, Lauren A Webster, Christy Paterson, John Thomas, Mirtha Elisa Aguado, Enrique Colina Araújo, Daniel Alpízar-Pedraza, Halimatu Joji, Lorna MacLean, Anthony Hope, David W Gray, Martin Zoltner, Mark C Field, Jorge González-Bacerio, Manu De Rycker
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 18, Iss 2, p e0011956 (2024)
BackgroundChagas disease is caused by the protozoan parasite Trypanosoma cruzi and leads to ~10,000 deaths each year. Nifurtimox and benznidazole are the only two drugs available but have significant adverse effects and limited efficacy. New chemothe
Externí odkaz:
https://doaj.org/article/eda16b548238447697b8e6f336b5e1ca
Design of the Global Health chemical diversity library v2 for screening against infectious diseases.
Autor:
Caroline Wilson, J Mark F Gardner, David W Gray, Beatriz Baragana, Paul G Wyatt, Alex Cookson, Stephen Thompson, Cesar Mendoza-Martinez, Michael J Bodkin, Ian H Gilbert, Gary J Tarver
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 17, Iss 12, p e0011799 (2023)
There is a need for novel chemical matter for phenotypic and target-based screens to find starting points for drug discovery programmes in neglected infectious diseases and non-hormonal contraceptives that disproportionately affect Low- and Middle-In
Externí odkaz:
https://doaj.org/article/ae7dc23b661c42e4b35f3b3a4b1a1f7f
Autor:
Erwan Beauchamp, Megan C. Yap, Aishwarya Iyer, Maneka A. Perinpanayagam, Jay M. Gamma, Krista M. Vincent, Manikandan Lakshmanan, Anandhkumar Raju, Vinay Tergaonkar, Soo Yong Tan, Soon Thye Lim, Wei-Feng Dong, Lynne M. Postovit, Kevin D. Read, David W. Gray, Paul G. Wyatt, John R. Mackey, Luc G. Berthiaume
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
N-myristoyltransferases (NMTs) target many signaling proteins to membranes. Here the authors show an NMT inhibitor named PCLX-001 selectively kills lymphoma cells by shutting down their main survival signaling pathway and offers an additional treatme
Externí odkaz:
https://doaj.org/article/bfdadd6d979a442fbc358345f3c1fc33
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 15, Iss 10, p e0009870 (2021)
Chagas disease, caused by the protozoan intracellular parasite Trypanosoma cruzi, is a highly neglected tropical disease, causing significant morbidity and mortality in central and south America. Current treatments are inadequate, and recent clinical
Externí odkaz:
https://doaj.org/article/0428e734a42f4d65a9fe295ff74ee419
Autor:
James S. Martin, Claire J. Mackenzie, De Lin, Nadine Homeyer, David W. Gray, Fabio Zuccotto, Ian H. Gilbert
Publikováno v:
ACS Omega. 8:12787-12804
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3ce02eeb04ff7b9d23bcab7c2b09d305
https://doi.org/10.1021/acsomega.2c08031
https://doi.org/10.1021/acsomega.2c08031
Publikováno v:
PLoS ONE, Vol 14, Iss 5, p e0217828 (2019)
The discovery of 20 unconventional kinetochore proteins in Trypanosoma brucei has opened a new and interesting area of evolutionary research to study a biological process previously thought to be highly conserved in all eukaryotes. In addition, the d
Externí odkaz:
https://doaj.org/article/10a149edc2654e08b646177273df4903
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 12, Iss 7, p e0006612 (2018)
Chagas' disease is responsible for significant mortality and morbidity in Latin America. Current treatments display variable efficacy and have adverse side effects, hence more effective, better tolerated drugs are needed. However, recent efforts have
Externí odkaz:
https://doaj.org/article/288def2732bd4cd0ab8accddd72b0e04
Autor:
De Lin, Charlotte J. Green, Alain-Pierre Petit, David W. Gray, Euan A. F. Fordyce, Victoria H. Cowling, Lesley-Anne Pearson
Publikováno v:
Slas Discovery
Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) represents a significant threat to human health. Despite its similarity to related coronaviruses, there are currently no specific treatments for COVID-19 infection, and therefore there is a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7027608aefa24d7689fc44d214c89e8c
https://doi.org/10.1177/24725552211000652
https://doi.org/10.1177/24725552211000652
Autor:
Clifton E. Barry, Paul G. Wyatt, Yoshitaka Tateishi, Andaleeb Sajid, M. Daben J. Libardo, Sangmi Oh, Caroline J. Duncombe, Peter C. Ray, David W. Gray, Gary T. Pauly, Jose Santinni O Roma, Thomas R. Ioerger, Helena I. Boshoff, Shaik Azeeza, Michael Goodwin
Publikováno v:
ACS Infectious Diseases. 7:479-492
Pyrazolo[1,5-a]pyrimidin-7(4H)-one was identified through high-throughput whole-cell screening as a potential antituberculosis lead. The core of this scaffold has been identified several times previously and has been associated with various modes of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f2b286eaa3ebb59880cbd57cff884986
https://doi.org/10.1021/acsinfecdis.0c00851
https://doi.org/10.1021/acsinfecdis.0c00851
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 10, Iss 4, p e0004584 (2016)
Chagas disease is a significant health problem in Latin America and the available treatments have significant issues in terms of toxicity and efficacy. There is thus an urgent need to develop new treatments either via a repurposing strategy or throug
Externí odkaz:
https://doaj.org/article/71682c789615451a96ec345def4d4288