Zobrazeno 1 - 10
of 424
pro vyhledávání: '"David W, Boykin"'
Autor:
Mélanie Lambert, Samy Jambon, Mohamed A. Bouhlel, Sabine Depauw, Julie Vrevin, Samuel Blanck, Guillemette Marot, Martin Figeac, Claude Preudhomme, Bruno Quesnel, David W. Boykin, Marie‐Hélène David‐Cordonnier
Publikováno v:
HemaSphere, Vol 8, Iss 5, Pp n/a-n/a (2024)
Abstract The mainstay of acute myeloid leukemia (AML) treatment still relies on traditional chemotherapy, with a survival rate of approximately 30% for patients under 65 years of age and as low as 5% for those beyond. This unfavorable prognosis prima
Externí odkaz:
https://doaj.org/article/a3c13963554d4ef19b2516b082160eb0
Autor:
Bruno Lisboa Timm, Aline Nefertiti Silva da Gama, Marcos Meuser Batista, Denise da Gama Jaén Batista, David W. Boykin, Harry P. De Koning, Maria de Nazaré Correia Soeiro
Publikováno v:
Pathogens, Vol 12, Iss 5, p 701 (2023)
Chagas disease (CD) affects over 6 million people worldwide and can be transmitted iatrogenically. Crystal violet (CV) was previously used for pathogen reduction but has harmful side-effects. In the present study, three arylimidamides (AIAs) and CV w
Externí odkaz:
https://doaj.org/article/165e271ca3f847f4b2c23c8eb3c9a7f4
Publikováno v:
Life, Vol 12, Iss 5, p 681 (2022)
Ken Breslauer began studies on the thermodynamics of small cationic molecules binding in the DNA minor groove over 30 years ago, and the studies reported here are an extension of those ground-breaking reports. The goals of this report are to develop
Externí odkaz:
https://doaj.org/article/195dc44dee6040369a654f4f3bdfe658
Autor:
Ali H Alghamdi, Jane C Munday, Gustavo Daniel Campagnaro, Dominik Gurvic, Fredrik Svensson, Chinyere E Okpara, Arvind Kumar, Juan Quintana, Maria Esther Martin Abril, Patrik Milić, Laura Watson, Daniel Paape, Luca Settimo, Anna Dimitriou, Joanna Wielinska, Graeme Smart, Laura F Anderson, Christopher M Woodley, Siu Pui Ying Kelly, Hasan MS Ibrahim, Fabian Hulpia, Mohammed I Al-Salabi, Anthonius A Eze, Teresa Sprenger, Ibrahim A Teka, Simon Gudin, Simone Weyand, Mark Field, Christophe Dardonville, Richard R Tidwell, Mark Carrington, Paul O'Neill, David W Boykin, Ulrich Zachariae, Harry P De Koning
Publikováno v:
eLife, Vol 9 (2020)
Mutations in the Trypanosoma brucei aquaporin AQP2 are associated with resistance to pentamidine and melarsoprol. We show that TbAQP2 but not TbAQP3 was positively selected for increased pore size from a common ancestor aquaporin. We demonstrate that
Externí odkaz:
https://doaj.org/article/04cf21046dd94dac9faba5a20eaa5348
Autor:
Roberto Simone, Rubika Balendra, Thomas G Moens, Elisavet Preza, Katherine M Wilson, Amanda Heslegrave, Nathan S Woodling, Teresa Niccoli, Javier Gilbert‐Jaramillo, Samir Abdelkarim, Emma L Clayton, Mica Clarke, Marie‐Therese Konrad, Andrew J Nicoll, Jamie S Mitchell, Andrea Calvo, Adriano Chio, Henry Houlden, James M Polke, Mohamed A Ismail, Chad E Stephens, Tam Vo, Abdelbasset A Farahat, W David Wilson, David W Boykin, Henrik Zetterberg, Linda Partridge, Selina Wray, Gary Parkinson, Stephen Neidle, Rickie Patani, Pietro Fratta, Adrian M Isaacs
Publikováno v:
EMBO Molecular Medicine, Vol 10, Iss 1, Pp 22-31 (2017)
Abstract Intronic GGGGCC repeat expansions in C9orf72 are the most common known cause of frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS), which are characterised by degeneration of cortical and motor neurons, respectively. Repea
Externí odkaz:
https://doaj.org/article/1f8b61ee6cea4757929c90eeb5c2d015
Autor:
Bingchen Yu, Manjusha Roy Choudhury, Xiaoxiao Yang, Stéphane L. Benoit, Edroyal Womack, Kristin Van Mouwerik Lyles, Atanu Acharya, Arvind Kumar, Ce Yang, Anna Pavlova, Mengyuan Zhu, Zhengnan Yuan, James C. Gumbart, David W. Boykin, Robert J. Maier, Zehava Eichenbaum, Binghe Wang
Publikováno v:
ACS Infectious Diseases. 8:1491-1508
The rapid and persistent emergence of drug-resistant bacteria poses a looming public health crisis. The possible task of developing new sets of antibiotics to replenish the existing ones is daunting to say the least. Searching for adjuvants that rest
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::adadf5703cc696bb0d78aef3323554d7
https://doi.org/10.1021/acsinfecdis.2c00121
https://doi.org/10.1021/acsinfecdis.2c00121
Autor:
Edwin N. Ogbonna, Ananya Paul, Abdelbasset A. Farahat, J. Ross Terrell, Ekaterina Mineva, Victor Ogbonna, David W Boykin, W. David Wilson
Publikováno v:
ACS Bio & Med Chem Au.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bce4459c3795d2e10328487b14578309
https://doi.org/10.1021/acsbiomedchemau.3c00002
https://doi.org/10.1021/acsbiomedchemau.3c00002
Autor:
Abdelbasset A. Farahat, Arvind Kumar, Tanja Wenzler, Reto Brun, Ananya Paul, Pu Guo, W. David Wilson, David W. Boykin
New analogs of the antiprotozoal agent Furamidine were prepared utilizing Stille coupling reactions and amidation of the bisnitrile intermediate using lithium bis-trimethylsilylamide. Both the phenyl groups and the furan moiety of furamidine were rep
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e49411482d3e0a0f86edc530532fd2a
Publikováno v:
Journal of Heterocyclic Chemistry. 58:2280-2286
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::56d93db843dfff726f2777cf7d2d02eb
https://doi.org/10.1002/jhet.4353
https://doi.org/10.1002/jhet.4353
Publikováno v:
Molecules, Vol 24, Iss 5, p 946 (2019)
We review the preparation of new compounds with good solution and cell uptake properties that can selectively recognize mixed A·T and G·C bp sequences of DNA. Our underlying aim is to show that these new compounds provide important new biotechnolog
Externí odkaz:
https://doaj.org/article/9586be5de2e64df4924462551d1357ea