Zobrazeno 1 - 10
of 523
pro vyhledávání: '"David W, Andrews"'
Autor:
Diandra Zipinotti dos Santos, Mohamad Elbaz, Emily Branchard, Wiebke Schormann, Carla E. Brown, Autumn R. Meek, Vincent C.O. Njar, Robert J. Hamilton, Mark A. Reed, David W. Andrews, Linda Z. Penn
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 177, Iss , Pp 116934- (2024)
There is an urgent need to provide immediate and effective options for the treatment of prostate cancer (PCa) to prevent progression to lethal castration-resistant PCa (CRPC). The mevalonate (MVA) pathway is dysregulated in PCa, and statin drugs comm
Externí odkaz:
https://doaj.org/article/699af22ca7604478ae0e47c46ba49ef6
Autor:
Martin Cottet, Yuniel Fernandez Marrero, Simon Mathien, Karine Audette, Raphaelle Lambert, Eric Bonneil, Kenneth Chng, Alex Campos, David W. Andrews
Publikováno v:
SLAS Discovery, Vol 29, Iss 3, Pp 100121- (2024)
High-content imaging approaches, in combination with the use of perturbing agents such as small molecules or CRISPR-driven gene editing, have widely contributed to the identification of new therapeutic compounds. Thanks to recent advances in image-an
Externí odkaz:
https://doaj.org/article/5564449d6c78415e9c5915e263f7b2df
Autor:
Lorenzo Galluzzi, Jenny Zilberberg, Amelia Zellander, Kenneth Kirby, Christopher Uhl, Christopher Cultrara, Essam Abed Elrazaq, David W Andrews, Charles B Scott, Mark A Exley
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss 8 (2023)
Background IGV-001 is a personalized, autologous cancer cell-based immunotherapy conceived to deliver a tumor-derived antigenic payload in the context of immunostimulatory signals to patients with glioblastoma (GBM). IGV-001 consists of patient-deriv
Externí odkaz:
https://doaj.org/article/4dcff276a1bf4922837be3e5877e9195
Autor:
Jenna E. van Leeuwen, Wail Ba-Alawi, Emily Branchard, Jennifer Cruickshank, Wiebke Schormann, Joseph Longo, Jennifer Silvester, Peter L. Gross, David W. Andrews, David W. Cescon, Benjamin Haibe-Kains, Linda Z. Penn, Deena M. A. Gendoo
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)
Statins are promising for breast cancer therapy; dipyridamole can potentiate their effects, but is contraindicated in some cases. Here, the authors develop a pharmacogenomics pipeline to predict other compounds that potentiate statins, and validate t
Externí odkaz:
https://doaj.org/article/f57984f909454f0787ee786ab65589d9
Autor:
James M Pemberton, Dang Nguyen, Elizabeth J Osterlund, Wiebke Schormann, Justin P Pogmore, Nehad Hirmiz, Brian Leber, David W Andrews
Publikováno v:
eLife, Vol 12 (2023)
Anti-apoptotic proteins such as BCL-XL promote cell survival by sequestering pro-apoptotic BCL-2 family members, an activity that frequently contributes to tumorigenesis. Thus, the development of small-molecule inhibitors for anti-apoptotic proteins,
Externí odkaz:
https://doaj.org/article/c46858294f8f416e96855c98bce4cf03
Publikováno v:
BMC Genomics, Vol 20, Iss 1, Pp 1-21 (2019)
Abstract Background Tail-anchored membrane proteins (TAMPs) differ from other integral membrane proteins, because they contain a single transmembrane domain at the extreme carboxyl-terminus and are therefore obliged to target to membranes post-transl
Externí odkaz:
https://doaj.org/article/8a3a5db215e74e0eadc351be7ff63b59
Publikováno v:
Journal of Research in Innovative Teaching & Learning, Vol 14, Iss 1, Pp 2-4 (2021)
Externí odkaz:
https://doaj.org/article/fdf5178a8b6f4c4f813fabb50c589835
Autor:
Philipp Mergenthaler, Santosh Hariharan, James M Pemberton, Corey Lourenco, Linda Z Penn, David W Andrews
Publikováno v:
PLoS Computational Biology, Vol 17, Iss 2, p e1008630 (2021)
Phenotypic profiling of large three-dimensional microscopy data sets has not been widely adopted due to the challenges posed by cell segmentation and feature selection. The computational demands of automated processing further limit analysis of hard-
Externí odkaz:
https://doaj.org/article/7cf9a9f1db0c4ccd8dbc99d773e496ea
Autor:
Ayesha S. Ali, Joseph Lombardo, Muneeb Z Niazi, Ryan C Miller, Iyad Alnahhas, Nina L Martinez, David W. Andrews, Kevin D Judy, Wenyin Shi
Publikováno v:
Journal of Neuro-Oncology. 160:345-350
Autor:
Xiaoke Chi, Dang Nguyen, James M Pemberton, Elizabeth J Osterlund, Qian Liu, Hetal Brahmbhatt, Zhi Zhang, Jialing Lin, Brian Leber, David W Andrews
Publikováno v:
eLife, Vol 9 (2020)
The Bcl-2 family BH3 protein Bim promotes apoptosis at mitochondria by activating the pore-forming proteins Bax and Bak and by inhibiting the anti-apoptotic proteins Bcl-XL, Bcl-2 and Mcl-1. Bim binds to these proteins via its BH3 domain and to the m
Externí odkaz:
https://doaj.org/article/3930186c3fd04ad4a33907088e2464c2