Zobrazeno 1 - 10
of 64
pro vyhledávání: '"David Vilchez"'
Autor:
Nyasha Charura, Ernesto Llamas, Concetta De Quattro, David Vilchez, Moritz K Nowack, Alga Zuccaro
Publikováno v:
eLife, Vol 13 (2024)
Programmed cell death occurring during plant development (dPCD) is a fundamental process integral for plant growth and reproduction. Here, we investigate the connection between developmentally controlled PCD and fungal accommodation in Arabidopsis th
Externí odkaz:
https://doaj.org/article/10c0fdebefb74222aa33eabc7ea491ff
Autor:
Hafiza Alirzayeva, Rute Loureiro, Seda Koyuncu, Franziska Hommen, Yara Nabawi, William Hongyu Zhang, Thien T.P. Dao, Markus Wehrmann, Hyun Ju Lee, David Vilchez
Publikováno v:
Cell Reports, Vol 43, Iss 8, Pp 114626- (2024)
Summary: The majority of severe early-onset and juvenile cases of amyotrophic lateral sclerosis (ALS) are caused by mutations in the FUS gene, resulting in rapid disease progression. Mutant FUS accumulates within stress granules (SGs), thereby affect
Externí odkaz:
https://doaj.org/article/46204d1312a246e397d7c26f78738b90
Autor:
Felix Kohle, Robin Ackfeld, Franziska Hommen, Ines Klein, Martin K. R. Svačina, Christian Schneider, Gereon R. Fink, Mohammed Barham, David Vilchez, Helmar C. Lehmann
Publikováno v:
Journal of Neuroinflammation, Vol 20, Iss 1, Pp 1-13 (2023)
Abstract Background Autoimmune neuropathies can result in long-term disability and incomplete recovery, despite adequate first-line therapy. Kinesin-5 inhibition was shown to accelerate neurite outgrowth in different preclinical studies. Here, we eva
Externí odkaz:
https://doaj.org/article/7e8462d3a78c4041824d1c987335394b
Autor:
Markus Wehrmann, David Vilchez
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Deubiquitinating enzymes (DUBs) are emerging as key factors for the infection of human cells by pathogens such as bacteria and parasites. In this review, we discuss the most recent studies on the role of deubiquitinase activity in exploiting and mani
Externí odkaz:
https://doaj.org/article/4ee37f009df648638abe8e781114d7f1
Publikováno v:
Frontiers in Aging, Vol 3 (2022)
Protein homeostasis (proteostasis) is maintained by a tightly regulated and interconnected network of biological pathways, preventing the accumulation and aggregation of damaged or misfolded proteins. Thus, the proteostasis network is essential to en
Externí odkaz:
https://doaj.org/article/0fd85621e8e64df1abfeada0b8eb033f
Autor:
Caroline Kumsta, Jessica T. Chang, Reina Lee, Ee Phie Tan, Yongzhi Yang, Rute Loureiro, Elizabeth H. Choy, Shaun H. Y. Lim, Isabel Saez, Alexander Springhorn, Thorsten Hoppe, David Vilchez, Malene Hansen
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
While the cellular recycling process autophagy has been linked to aging, the impact of selective autophagy on lifespan remains unclear. Here Kumsta et al. show that the autophagy receptor p62/SQSTM1 is required for hormetic benefits and p62/SQSTM1 ov
Externí odkaz:
https://doaj.org/article/1e02eb157af547f08c179b3732ae4d95
Autor:
Seda Koyuncu, Isabel Saez, Hyun Ju Lee, Ricardo Gutierrez-Garcia, Wojciech Pokrzywa, Azra Fatima, Thorsten Hoppe, David Vilchez
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-22 (2018)
Induced pluripotent stem cells (iPSCs) suppress the aggregation of Huntington’s disease (HD) polyQ-expanded huntingtin (HTT). Here the authors show that proteasome activity determines the levels of mutant HTT in HD-iPSCs and find that UBR5 is a mod
Externí odkaz:
https://doaj.org/article/3208ae5c34064dfaa117ff00fd735b20
Autor:
Hyun Ju Lee, Deniz Bartsch, Cally Xiao, Santiago Guerrero, Gaurav Ahuja, Christina Schindler, James J. Moresco, John R. Yates, Fátima Gebauer, Hisham Bazzi, Christoph Dieterich, Leo Kurian, David Vilchez
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-19 (2017)
Unlike transcriptional regulation of hESC identity, little is known post-transcriptionally. Here, the authors show that the RNA binding protein CSDE1 regulates core components of hESC identity, neurectoderm commitment and neurogenesis to maintain plu
Externí odkaz:
https://doaj.org/article/8b637ecfb83f4e0ea34de34086340b09
Autor:
Alireza Noormohammadi, Amirabbas Khodakarami, Ricardo Gutierrez-Garcia, Hyun Ju Lee, Seda Koyuncu, Tim König, Christina Schindler, Isabel Saez, Azra Fatima, Christoph Dieterich, David Vilchez
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-15 (2016)
Pluripotent stem cells are thought to require a highly active proteostatic machinery. Here, the authors show that CCT8, a subunit of the proteostatic chaperonin complex, is increased in pluripotent stem cells, and that overexpression of CCT8 in worms
Externí odkaz:
https://doaj.org/article/84731adf22554679bbacd32bdb3db949
Autor:
Seda Koyuncu, Isabel Saez, Hyun Ju Lee, Ricardo Gutierrez-Garcia, Wojciech Pokrzywa, Azra Fatima, Thorsten Hoppe, David Vilchez
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-1 (2020)
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Externí odkaz:
https://doaj.org/article/9bacf3d990d64e3dbaa2d6facf15cabc