Zobrazeno 1 - 10
of 14
pro vyhledávání: '"David Vicente-Zurdo"'
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 11, p 5906 (2024)
Alzheimer’s Disease (AD), a prevalent neurodegenerative disorder, is the primary cause of dementia. Despite significant advancements in neuroscience, a definitive cure or treatment for this debilitating disease remains elusive. A notable characteri
Externí odkaz:
https://doaj.org/article/0f38db65eee14160b0457953ddb7e670
Autor:
Sandra Rodríguez-Blázquez, Laura Pedrera-Cajas, Esther Gómez-Mejía, David Vicente-Zurdo, Noelia Rosales-Conrado, María Eugenia León-González, Juan José Rodríguez-Bencomo, Ruben Miranda
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 2, p 1236 (2024)
Bioactive compounds extracted from plum seeds were identified and quantified, aiming to establish how the brandy manufacturing process affects the properties and possible cascade valorization of seed residues. Extraction with n-hexane using Soxhlet h
Externí odkaz:
https://doaj.org/article/ede3338202a64a61a9f86ac24f2d2f1d
Autor:
David Vicente-Zurdo, Leonardo Brunetti, Luca Piemontese, Beatriz Guedes, Sandra M. Cardoso, Daniel Chavarria, Fernanda Borges, Yolanda Madrid, Sílvia Chaves, M. Amélia Santos
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 9, p 8312 (2023)
With the goal of combating the multi-faceted Alzheimer’s disease (AD), a series of Rivastigmine-Benzimidazole (RIV–BIM) hybrids was recently reported by us as multitarget-directed ligands, thanks to their capacity to tackle important hallmarks of
Externí odkaz:
https://doaj.org/article/f5a6f12e33d1420c80a414f77067efd5
Autor:
David Vicente-Zurdo, Noelia Rosales-Conrado, M. Eugenia León-González, Leonardo Brunetti, Luca Piemontese, A. Raquel Pereira-Santos, Sandra M. Cardoso, Yolanda Madrid, Sílvia Chaves, M. Amélia Santos
Publikováno v:
Biomedicines, Vol 10, Iss 7, p 1510 (2022)
Alzheimer’s disease (AD) is the most serious and prevalent neurodegenerative disorder still without cure. Since its aetiology is diverse, recent research on anti-AD drugs has been focused on multi-target compounds. In this work, seven novel hybrids
Externí odkaz:
https://doaj.org/article/bb8b37ac68d846fe80f3c1a79f47530c
Autor:
David Vicente-Zurdo, Sandra Rodríguez-Blázquez, Esther Gómez-Mejía, Noelia Rosales-Conrado, María Eugenia León-González, Yolanda Madrid
Publikováno v:
Analytical and bioanalytical chemistry. 414(26)
Alzheimer's disease (AD), the most prevalent neurodegenerative disease, is characterized by extracellular accumulation of amyloid-beta protein (Aβ), which is believed to be the very starting event of AD neurodegeneration. In this work, D-Phe, D-Ala,
Autor:
Paula Moyano, David Vicente-Zurdo, Cristina Blázquez-Barbadillo, J. Carlos Menéndez, Juan F. González, Noelia Rosales-Conrado, Javier del Pino
Publikováno v:
E-Prints Complutense. Archivo Institucional de la UCM
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Brain's metals accumulation is associated with toxic proteins, like amyloid-proteins (Aβ), formation, accumulation, and aggregation, leading to neurodegeneration. Metals downregulate the correct folding, disaggregation, or degradation mechanisms of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9cdff1b64dc43f713df796e8b497f266
https://eprints.ucm.es/id/eprint/73454/
https://eprints.ucm.es/id/eprint/73454/
Autor:
David Vicente-Zurdo, Beatriz Gómez-Gómez, Iván Romero-Sánchez, Noelia Rosales-Conrado, María Eugenia León-González, Yolanda Madrid
Publikováno v:
Analytica Chimica Acta. 1249:340949
Autor:
Yolanda Madrid, Noelia Rosales-Conrado, María Eugenia León-González, Iván Romero-Sánchez, David Vicente-Zurdo
Publikováno v:
Analytical and Bioanalytical Chemistry. 412:6485-6497
Extracellular accumulation of amyloid beta peptide (Aβ) is believed to be one of the main factors responsible for neurodegeneration in Alzheimer’s disease (AD). Metals could induce Aβ aggregation, by their redox activity or binding properties to
Autor:
Cristina Blázquez-Barbadillo, Paula Moyano, David Vicente-Zurdo, Juan Francisco González, Noelia Rosales-Conrado, J. Carlos Menéndez, Javier del Pino
Publikováno v:
ACS Chemical Neuroscience
E-Prints Complutense. Archivo Institucional de la UCM
instname
E-Prints Complutense. Archivo Institucional de la UCM
instname
Neurodegenerative diseases have been associated with brain metal accumulation, which produces oxidative stress (OS), matrix metalloproteinases (MMPs) induction, and neuronal cell death. Several metals have been reported to downregulate both the nucle
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9110c0f1fa74259ba613defbf64d59f9
https://eprints.ucm.es/id/eprint/69341/
https://eprints.ucm.es/id/eprint/69341/
Autor:
Juan Francisco González, Javier del Pino, J. Carlos Menéndez, Paula Moyano, Cristina Blázquez-Barbadillo, David Vicente-Zurdo, Damiano Rocchi, Antonio Laghezza, Paolo Tortorella, Noelia Rosales-Conrado, Mariangela Agamennone
Publikováno v:
European journal of medicinal chemistry. 210
Matrix metalloproteinases (MMPs) are zinc-dependent hydrolytic enzymes of great biological relevance, and some of them are key to the neuroinflammatory events and the brain damage associated to stroke. Non-zinc binding ligands are an emerging trend i