Výsledky vyhledávání - "David Vergote"

Bridging Integrator 1 (BIN1, rs6733839) and Sex Are Moderators of Vascular Health Predictions of Memory Aging Trajectories

Autor: Mackenzie Heal, G. Peggy McFall, David Vergote, Jack H. Jhamandas, David Westaway, Roger A. Dixon

Publikováno v: Journal of Alzheimer's Disease. 89:265-281

Background: A promising risk loci for sporadic Alzheimer’s disease (AD), Bridging Integrator 1 (BIN1), is thought to operate through the tau pathology pathway. Objective: We examine BIN1 risk for a moderating role with vascular health (pulse pressu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb0162e152bd637c4c493b723aa90820
https://doi.org/10.3233/jad-220334

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Role of Cathepsin D in U18666A-induced Neuronal Cell Death

Autor: Timothy J. Revett, Satyabrata Kar, Yanlin Wang, A. Amritraj, David Westaway, David Vergote

Publikováno v: Journal of Biological Chemistry. 288:3136-3152

Cathepsin D is an aspartyl protease that plays a crucial role in normal cellular functions and in a variety of neurodegenerative disorders, including Niemann-Pick type C (NPC) disease, which is characterized by intracellular accumulation of cholester

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::83afd335da9bf1d98c9fe9821404dfe2
https://doi.org/10.1074/jbc.m112.412460

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Vascular Health and Genetic Risk Affect Mild Cognitive Impairment Status and 4-Year Stability: Evidence From the Victoria Longitudinal Study

Autor: Jack H. Jhamandas, Roger A. Dixon, David Westaway, David Vergote, Correne A. DeCarlo, Stuart W. S. MacDonald

Objectives Mild cognitive impairment (MCI) is a high-risk condition for progression to Alzheimer's disease (AD). Vascular health is a key mechanism underlying age-related cognitive decline and neurodegeneration. AD-related genetic risk factors may be

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61911fa500da9a75986942224aba71a3
https://europepmc.org/articles/PMC5067948/

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Up-regulation of Neurohemerythrin Expression in the Central Nervous System of the Medicinal Leech, Hirudo medicinalis, following Septic Injury

Autor: David Vergote, Pierre-Eric Sautière, Franck Vandenbulcke, Guillaume Mitta, Didier Vieau, Eduardo R. Macagno, Michel Salzet

Publikováno v: Journal of Biological Chemistry. 279:43828-43837

We report here some results of a proteomic analysis of changes in protein expression in the leech Hirudo medicinalis in response to septic injury. Comparison of two-dimensional protein gels revealed several significant differences between normal and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c90621e20c236adeba8d276664eb7339
https://doi.org/10.1074/jbc.m403073200

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(−)-Epigallocatechin (EGC) of Green Tea Induces Apoptosis of Human Breast Cancer Cells But Not of their Normal Counterparts

Autor: David Vergote, Cécile Cren-Olivé, Valérie Chopin, Xuefen Le Bourhis, Hubert Hondermarck, Christian Rolando, Robert-Alain Toillon

Publikováno v: Breast Cancer Research and Treatment. 76:195-201

(-)-Epigallocatechin (EGC), one of green tea polyphenols, has been shown to inhibit growth of cancer cells. However its mechanism of action is poorly known. We show here that EGC strongly inhibited the growth of breast cancer cell lines (MCF-7 and MD

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20543544c12b2be783b5806b0b8d8d5e
https://doi.org/10.1023/a:1020833410523

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ApoE and Pulse Pressure Interactively Influence Level and Change in the Aging of Episodic Memory: Protective Effects Among ε2 Carriers

Autor: David Westaway, G. Peggy McFall, Roger A. Dixon, David Vergote, Sandra A. Wiebe, Jack H. Jhamandas, Lars Bäckman

Objective: We tested independent and interactive effects of Apolipoprotein E (ApoE) and pulse pressure (PP) concurrently and longitudinally across 9 years (3 waves) of episodic (EM) and semantic memory (SM) data from the Victoria Longitudinal Study.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a47dbfb3e10c5405e623e667318b7650
https://europepmc.org/articles/PMC4420712/

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IDE (rs6583817) polymorphism and pulse pressure are independently and interactively associated with level and change in executive function in older adults

Autor: Roger A. Dixon, G. Peggy McFall, Jack H. Jhamandas, David Westaway, Sandra A. Wiebe, David Vergote

Publikováno v: Psychology and aging. 29(2)

Objective: We report a gene x environment (health) study focusing on concurrent performance and longitudinal change in a latent-variable executive function (EF) phenotype. Specifically, we tested the independent and interactive effects of a recently

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53ccd82666204b35088a34b06352063e
https://pubmed.ncbi.nlm.nih.gov/24660790

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