Zobrazeno 1 - 10
of 17
pro vyhledávání: '"David Varga-Szabo"'
Autor:
Leif Schiffmann, Matthias Becker, Leendert Develing, David Varga-Szabo, Caroline Scheidereiter-Krüger, Hubert Zirngibl, Michael Seifert, Lothar Biermann, Claudia Schlüter, Felicitas Tumczak, Arved Weimann, Boris Jansen-Winkeln, Ingo Wallstabe, Frank Schwandner, Sandra Denecke, Clemens Schafmayer, Imad Kamaleddine, Albrecht Stier, Katharina Haegele, Michael Kindler, Sabine Michling, Ernst-Wilhelm Horling, Ulrike Denzer
Publikováno v:
Frontiers in Surgery, Vol 9 (2023)
BackgroundLow anterior resection for rectal cancer is commonly associated with a diverting stoma. In general, the stoma is closed 3 months after the initial operation. The diverting stoma reduces the rate of anastomotic leakage as well as the severen
Externí odkaz:
https://doaj.org/article/fa2b55ef083f4bb6ba94103d706fb425
Autor:
Irina Pleines, Alexander Dietrich, Bernhard Nieswandt, Ina Thielmann, Attila Braun, G. Ramanathan, Shuchi Gupta, Frauke May, Christine Mannhalter, David Varga-Szabo
Publikováno v:
Journal of Thrombosis and Haemostasis. 10:419-429
Summary. Background: Platelet adhesion, activation and aggregation at sites of vascular injury are essential processes for primary hemostasis. Elevation of the intracellular Ca2+ concentration is a central event in platelet activation but the underly
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a2f8d7cf5fdf297b05901a4a8f8c898
https://doi.org/10.1111/j.1538-7836.2011.04596.x
https://doi.org/10.1111/j.1538-7836.2011.04596.x
Autor:
Marijke J.E. Kuijpers, Roger van Kruchten, Marion A.H. Feijge, Karen Gilio, Alejandro Berna-Erro, Johan W. M. Heemskerk, Bernhard Nieswandt, David Stegner, Attila Braun, Paola E. J. van der Meijden, David Varga-Szabo
Publikováno v:
Journal of Biological Chemistry, 285(31), 23629-23638. American Society for Biochemistry and Molecular Biology, Inc.
In platelets, STIM1 has been recognized as the key regulatory protein in store-operated Ca(2+) entry (SOCE) with Orai1 as principal Ca(2+) entry channel. Both proteins contribute to collagen-dependent arterial thrombosis in mice in vivo. It is unclea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db3394d58219b6d101bf82e20a13dc25
https://doi.org/10.1074/jbc.m110.108696
https://doi.org/10.1074/jbc.m110.108696
Autor:
Timo Vögtle, David Varga-Szabo, Thomas Kerkau, Ronmy Rivera Galdos, Bernhard Nieswandt, Niklas Beyersdorf, Stephan Kissler, Attila Braun
Publikováno v:
The Journal of Immunology. 182:3390-3397
Store-operated Ca2+ entry (SOCE) is believed to be of pivotal importance in T cell physiology. To test this hypothesis, we generated mice constitutively lacking the SOCE-regulating Ca2+ sensor stromal interaction molecule 1 (STIM1). In vitro analyses
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8927eec7658404204baf2652fb1072c
https://doi.org/10.4049/jimmunol.0802888
https://doi.org/10.4049/jimmunol.0802888
Autor:
Attila Braun, David Varga-Szabo, Christoph Kleinschnitz, Irina Pleines, Markus Bender, Madeleine Austinat, Michael Bösl, Guido Stoll, Bernhard Nieswandt
Publikováno v:
Blood. 113:2056-2063
Platelet activation and aggregation at sites of vascular injury are essential for primary hemostasis, but are also major pathomechanisms underlying myocardial infarction and stroke. Changes in [Ca2+]i are a central step in platelet activation. In non
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::740361bd52a0f6ad2031ca59b55311c9
https://doi.org/10.1182/blood-2008-07-171611
https://doi.org/10.1182/blood-2008-07-171611
Autor:
Cord Brakebusch, David Varga-Szabo, Frauke May, Margitta Elvers, Irina Pleines, Miroslava Pozgajova, Bernhard Nieswandt, Anna Chrostek-Grashoff, Amrei Strehl
Publikováno v:
Pflügers Archiv - European Journal of Physiology. 457:1173-1185
Platelet activation at sites of vascular injury is triggered through different signaling pathways leading to activation of phospholipase (PL) Cbeta or PLCgamma2. Active PLCs trigger Ca(2+) mobilization and entry, which is a prerequisite for adhesion,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9e346ce57dd7a09c26c48108415a8c1
https://doi.org/10.1007/s00424-008-0573-7
https://doi.org/10.1007/s00424-008-0573-7
Store-operated Ca2+ entry in platelets occurs independently of transient receptor potential (TRP) C1
Autor:
Archana Ambily, Alexander Dietrich, Bernhard Nieswandt, Thomas Gudermann, Kalwant S. Authi, Markus Bender, Sheila R. Hassock, Attila Braun, David Varga-Szabo
Publikováno v:
Pflügers Archiv - European Journal of Physiology. 457:377-387
Changes in [Ca(2+)](i) are a central step in platelet activation. In nonexcitable cells, receptor-mediated depletion of intracellular Ca(2+) stores triggers Ca(2+) entry through store-operated calcium (SOC) channels. Stromal interaction molecule 1 (S
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4da85d86ef1c8c7c0ab2c74c5847da1
https://doi.org/10.1007/s00424-008-0531-4
https://doi.org/10.1007/s00424-008-0531-4
Autor:
David Varga-Szabo, Markus Bender, Takashi Saito, Rastislav Pozgaj, Tamer Rabie, François Lanza, Bernhard Nieswandt, Stephen P. Watson
Publikováno v:
Blood. 110:529-535
Coronary artery thrombosis is often initiated by platelet activation on collagen-rich subendothelial layers in the disrupted atherosclerotic plaque. The activating platelet collagen receptor glycoprotein VI (GPVI) noncovalently associates with the Fc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c82ef47036f062a16bf07b701282855a
https://doi.org/10.1182/blood-2006-11-058107
https://doi.org/10.1182/blood-2006-11-058107
Autor:
Markus Moser, David Varga-Szabo, Reinhard Fässler, David R. Critchley, Susan J. Monkley, Irina Pleines, Bernhard Nieswandt
Publikováno v:
The Journal of Experimental Medicine
Platelet adhesion and aggregation at sites of vascular injury are essential for normal hemostasis but may also lead to pathological thrombus formation, causing diseases such as myocardial infarction or stroke. Heterodimeric receptors of the integrin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::867c3c25b7fb356f4b191fd0910fdf7a
http://europepmc.org/articles/PMC2150972
http://europepmc.org/articles/PMC2150972
Autor:
Christian Gachet, Valerie Schulte, Miroslava Pozgajova, David Varga-Szabo, H. Peter Reusch, Bernhard Nieswandt
Publikováno v:
Arteriosclerosis, Thrombosis, and Vascular Biology. 26:1640-1647
Objective— Collagen and thrombin are the strongest physiological platelet agonists, acting through different receptors, among which glycoprotein VI (GPVI) and protease-activated receptors, respectively, are the essential ones. In mice, targeting of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a662f6d5b8c3e9538c4deb011f4ab343
https://doi.org/10.1161/01.atv.0000225697.98093.ed
https://doi.org/10.1161/01.atv.0000225697.98093.ed