Zobrazeno 1 - 10
of 20
pro vyhledávání: '"David Van Ly"'
Autor:
David Van Ly, Alen Faiz, Christine Jenkins, Ben Crossett, Judith L Black, Brent McParland, Janette K Burgess, Brian G G Oliver
Publikováno v:
PLoS ONE, Vol 8, Iss 2, p e56058 (2013)
Rhinovirus (RV) infections account for approximately two thirds of all virus-induced asthma exacerbations and often result in an impaired response to β2 agonist therapy. Using an in vitro model of RV infection, we investigated the mechanisms underly
Externí odkaz:
https://doaj.org/article/0b7931eb10c44f7d82117f181d73dadd
Autor:
Karosham D. Reddy, Sandra Rutting, Corry-Anke Brandsma, Dikaia Xenaki, Jack Bozier, Brian G. Oliver, Yik Lung Chan, Hui Chen, Razia Zakarya, Ian M. Adcock, Roy R Woldhuis, David Van Ly
Publikováno v:
Thorax, 76(7), 647-655. BMJ PUBLISHING GROUP
RationaleIn COPD, small airway fibrosis occurs due to increased extracellular matrix (ECM) deposition in and around the airway smooth muscle (ASM) layer. Studies of immune cells and peripheral lung tissue have shown that epigenetic changes occur in C
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48f3909db847312782e8864b7f87650a
https://hdl.handle.net/11370/27cc7406-4155-4cac-95b0-f7016b66b1b5
https://hdl.handle.net/11370/27cc7406-4155-4cac-95b0-f7016b66b1b5
Autor:
Mark Read, V. Pragathi Masamsetti, Paul Timpson, Noa Lamm, Max Nobis, Scott G. Page, Anthony J. Cesare, Maté Biro, David Van Ly
Publikováno v:
Nature Cell Biology. 22:1460-1470
Filamentous actin (F-actin) provides cells with mechanical support and promotes the mobility of intracellular structures. Although F-actin is traditionally considered to be cytoplasmic, here we reveal that nuclear F-actin participates in the replicat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::49ee12b977e3291fb8e8724667c143a2
https://doi.org/10.1038/s41556-020-00605-6
https://doi.org/10.1038/s41556-020-00605-6
Autor:
Afshan McCarthy, Robert Blassberg, Georgia R. Kafer, Steven Howell, James Briscoe, Anthony J. Cesare, David Van Ly, Paulina Marzec, Phil Ruis, Kathy K. Niakan, Simon J. Boulton, Valerie Borel, Ambrosius P. Snijders
Publikováno v:
Nature
Mammalian telomeres protect chromosome ends from aberrant DNA repair1. TRF2, a component of the telomere-specific shelterin protein complex, facilitates end protection through sequestration of the terminal telomere repeat sequence within a lariat T-l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25f8cc69eb8ab195ddfc3f90c56f119c
https://doi.org/10.1038/s41586-020-2960-y
https://doi.org/10.1038/s41586-020-2960-y
Autor:
Robyn Lukeis, Duo Wang, Robert Max Conway, Sharron Liang, Svetlana Cherepanoff, Li-Anne Lim, Michael Giblin, David Van Ly, Luke B. Hesson
Publikováno v:
Ocul Oncol Pathol
Uveal melanoma (UM) is the commonest primary intraocular malignancy in adults. There is limited published data on lipid production in UM. Here, we describe the clinical, histological, immunohistochemical, and molecular findings in a ciliochoroidal me
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dad387ee307b8f0f8aed8a87116d7f60
https://europepmc.org/articles/PMC7772867/
https://europepmc.org/articles/PMC7772867/
Autor:
Noa, Lamm, Mark N, Read, Max, Nobis, David, Van Ly, Scott G, Page, V Pragathi, Masamsetti, Paul, Timpson, Maté, Biro, Anthony J, Cesare
Publikováno v:
Nature cell biology. 22(12)
Filamentous actin (F-actin) provides cells with mechanical support and promotes the mobility of intracellular structures. Although F-actin is traditionally considered to be cytoplasmic, here we reveal that nuclear F-actin participates in the replicat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::45682de39a9b02505fd17d1cbbceac78
https://pubmed.ncbi.nlm.nih.gov/33257806
https://pubmed.ncbi.nlm.nih.gov/33257806
Autor:
Pol Margalef, Anthony J. Cesare, Valerie Borel, Panagiotis Kotsantis, Dipanjan Chowdhury, Ambrosius P. Snijders, Grzegorz Sarek, Helen R. Flynn, David Van Ly, Phil Ruis, Simon J. Boulton, Xiaofeng Zheng
Publikováno v:
Nature
The protection of telomere ends by the shelterin complex prevents DNA damage signalling and promiscuous repair at chromosome ends. Evidence suggests that the 3′ single-stranded telomere end can assemble into a lasso-like t-loop configuration1,2, wh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76dc9c13f0a54e09659077d8c5a3823c
Autor:
Patrick C. Reading, Dominik Hartl, Brian G. Oliver, David Van Ly, Janette K. Burgess, Francesca Tang, Kirsten Spann, Katherine J. Baines
Publikováno v:
Respirology, 21(1), 172-179. Wiley
© 2015 The Authors. Respirology published by Wiley Publishing Asia Pty Ltd on behalf of Asian Pacific Society of Respirology. Background and objective Respiratory viral infections are a major cause of asthma exacerbations. Neutrophils accumulate in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7451e94b5432ed312a125bc343c6e5da
https://hdl.handle.net/11370/c8dbddc9-675f-40b2-9884-7ef03b41e6a5
https://hdl.handle.net/11370/c8dbddc9-675f-40b2-9884-7ef03b41e6a5
Autor:
Ronnie Ren Jie Low, Georgia R. Kafer, Tara K. Bartolec, David Van Ly, Anthony J. Cesare, Hilda A. Pickett, Katharina Gaus, Sonja Frölich
Publikováno v:
Molecular cell. 71(4)
Telomeres regulate DNA damage response (DDR) and DNA repair activity at chromosome ends. How telomere macromolecular structure contributes to ATM regulation and its potential dissociation from control over non-homologous end joining (NHEJ)-dependent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5275d0306036d8ae4e10b0d68148f153
https://pubmed.ncbi.nlm.nih.gov/30033372
https://pubmed.ncbi.nlm.nih.gov/30033372
Autor:
David Van Ly, Brian G. Oliver
Publikováno v:
Current Drug Delivery. 12:9-15
There is an enormous drive to refine therapeutic designs and delivery systems, but in this review we ask if this is always the right direction? We choose to play devil's advocate, and argue that refining drug design is not always needed, and what is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2b63e73ea9f541fc43ec3d886259c971
https://doi.org/10.2174/1567201811666140606112918
https://doi.org/10.2174/1567201811666140606112918