Brain matters: unveiling the distinct contributions of region, age, and sex to glia diversity and CNS function

Autor: Luise A. Seeker, Nadine Bestard-Cuche, Sarah Jäkel, Nina-Lydia Kazakou, Sunniva M. K. Bøstrand, Laura J. Wagstaff, Justyna Cholewa-Waclaw, Alastair M. Kilpatrick, David Van Bruggen, Mukund Kabbe, Fabio Baldivia Pohl, Zahra Moslehi, Neil C. Henderson, Catalina A. Vallejos, Gioele La Manno, Goncalo Castelo-Branco, Anna Williams

Publikováno v: Acta Neuropathologica Communications, Vol 11, Iss 1, Pp 1-23 (2023)

Abstract The myelinated white matter tracts of the central nervous system (CNS) are essential for fast transmission of electrical impulses and are often differentially affected in human neurodegenerative diseases across CNS region, age and sex. We hy

Externí odkaz: https://doaj.org/article/f29980c47b3d48f6bf0dc467b3b6f292

Marked regional glial heterogeneity in the human white matter of the central nervous system

Autor: Luise A. Seeker, Nadine Bestard-Cuche, Sarah Jäkel, Nina-Lydia Kazakou, Sunniva M. K. Bøstrand, Alastair M. Kilpatrick, David Van Bruggen, Mukund Kabbe, Fabio Baldivia Pohl, Zahra Moslehi, Neil C. Henderson, Catalina A. Vallejos, Gioele La Manno, Gonçalo Castelo-Branco, Anna Williams

The myelinated white matter tracts of the central nervous system (CNS) are essential for fast transmission of electrical impulses and are commonly affected in neurodegenerative diseases. However, these often uniquely human diseases differentially aff

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::504f779e658db9ca88dab21172277fd8
https://doi.org/10.1101/2022.03.22.485367

Distinct oligodendrocyte populations have spatial preference and different responses to spinal cord injury

Autor: Jonas Frisén, David van Bruggen, Shupei Zhang, Chika Yokota, Sara B. Mulinyawe, Markus M. Hilscher, Petra Kukanja, Muge Altinkok, Elisa M. Floriddia, Enric Llorens-Bobadilla, João P. Gonçalves dos Santos, Mats Nilsson, Mário Grãos, Lu O. Sun, Gonçalo Castelo-Branco, Tânia Lourenço

Publikováno v: Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
Nature Communications

Mature oligodendrocytes (MOLs) show transcriptional heterogeneity, the functional consequences of which are unclear. MOL heterogeneity might correlate with the local environment or their interactions with different neuron types. Here, we show that di

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50e6112a08bed40ed856f497d2bf1802
https://doi.org/10.1038/s41467-020-19453-x

Single-Cell RNA Sequencing of Oligodendrocyte Lineage Cells from the Mouse Central Nervous System

Autor: Sueli, Marques, David, van Bruggen, Gonçalo, Castelo-Branco

Publikováno v: Methods in molecular biology (Clifton, N.J.). 1936

Single-cell RNA sequencing has emerged as a powerful technique for the identification of distinct cell states/populations in complex tissues. We have recently used this technology to investigate heterogeneity of cells of the oligodendrocyte lineage i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::4548d5b6e8b76f9fbbc7d6f61660ffa1
https://pubmed.ncbi.nlm.nih.gov/30820890

Disease-specific oligodendrocyte lineage cells arise in multiple sclerosis

Autor: Anna Williams, Ana Mendanha Falcão, Darya P. Vanichkina, Mandy Meijer, Gonçalo Castelo-Branco, Sarah Jäkel, Samudyata, Eneritz Agirre, Sueli Marques, David van Bruggen, Charles ffrench-Constant, Elisa M. Floriddia, André Ortlieb Guerreiro-Cacais

Publikováno v: Mendanha Falcão, A, van Bruggen, D, Marques, S, Meijer, M, Jaekel, S, Agirre, E, Samudyata, Floriddia, E M, Vanichkina, D P, ffrench-Constant, C, Williams, A, Ortlieb Guerreiro-Cacais, A & Castelo-Branco, G 2018, ' Disease-specific oligodendrocyte lineage cells arise in multiple sclerosis ', Nature Medicine, vol. 24, no. 12, pp. 1837–1844 . https://doi.org/10.1038/s41591-018-0236-y
Nature Medicine

Multiple sclerosis (MS) is characterized by an immune system attack targeting myelin, which is produced by oligodendrocytes (OLs). We performed single-cell transcriptomic analysis of OL lineage cells from the spinal cord of mice induced with experime

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93de6ec6146168779a3274b56d78789f
https://www.pure.ed.ac.uk/ws/files/76565091/accepted_smaller.pdf