Characterization of Breast Cancer Preclinical Models Reveals a Specific Pattern of Macrophage Polarization.

Autor: David Vallerand, Gérald Massonnet, Fatima Kébir, David Gentien, Zofia Maciorowski, Pierre De la Grange, Brigitte Sigal-Zafrani, Marion Richardson, Sandrine Humbert, Aurélie Thuleau, Franck Assayag, Ludmilla de Plater, André Nicolas, Suzy Scholl, Elisabetta Marangoni, Stefan Weigand, Sergio Roman-Roman, Ariel Savina, Didier Decaudin

Publikováno v: PLoS ONE, Vol 11, Iss 7, p e0157670 (2016)

Drug discovery efforts have focused on the tumor microenvironment in recent years. However, few studies have characterized the stroma component in patient-derived xenografts (PDXs) and genetically engineered mouse models (GEMs). In this study, we cha

Externí odkaz: https://doaj.org/article/b13bb734dbd24545a1d6569df5464d20

Specific targeting of caspase-9/PP2A interaction as potential new anti-cancer therapy.

Autor: Issam Arrouss, Fariba Nemati, Fernando Roncal, Marie Wislez, Karim Dorgham, David Vallerand, Nathalie Rabbe, Narjesse Karboul, Françoise Carlotti, Jeronimo Bravo, Dominique Mazier, Didier Decaudin, Angelita Rebollo

Publikováno v: PLoS ONE, Vol 8, Iss 4, p e60816 (2013)

PURPOSE: PP2A is a serine/threonine phosphatase critical to physiological processes, including apoptosis. Cell penetrating peptides are molecules that can translocate into cells without causing membrane damage. Our goal was to develop cell-penetratin

Externí odkaz: https://doaj.org/article/9f541d1e4a454971b8d5263704e9489c

Correction: Mitochondrial clearance by the STK38 kinase supports oncogenic Ras-induced cell transformation

Autor: Marta Gomez, Alexander Hergovich, Ramazan Gundogdu, Michael A. White, Didier Surdez, Giulia Zago, Audrey Bettoun, Maria Carla Parrini, Ilaria Cascone, Patrice Codogno, David Vallerand, Brigitte Meunier, Carine Joffre, Ahmad A.D. Sharif, Jacques Camonis

Publikováno v: Oncotarget

Oncogenic Ras signalling occurs frequently in many human cancers. However, no effective targeted therapies are currently available to treat patients suffering from Ras-driven tumours. Therefore, it is imperative to identify downstream effectors of Ra

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d06d1c8178ec9694e9f5710b57e6502
https://doi.org/10.18632/oncotarget.25335

Targeting Bcl-2/Bcl-XL Induces Antitumor Activity in Uveal Melanoma Patient-Derived Xenografts

Autor: Lockhart Brian, Didier Decaudin, Xavier Sastre-Garau, Olivier Geneste, Stéphane Depil, Fariba Nemati, Ludmilla de Plater, Laurence Kraus-Berthier, Catherine de Montrion, Laurence Desjardins, Guillaume Carita, David Vallerand, Alain Pierre, Guillaume Lang, Sophie Piperno-Neumann, Aurélie Berniard

Publikováno v: PLoS ONE
PLoS ONE, Vol 9, Iss 1, p e80836 (2014)

PurposeUveal melanoma (UM) is associated with a high risk of metastases and lack of efficient therapies. Reduced capacity for apoptosis induction by chemotherapies is one obstacle to efficient treatments. Human UM is characterized by high expression

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7be32ae5238446d117009f9cab71d77e
http://europepmc.org/articles/PMC3890263

Specific Targeting of Caspase-9/PP2A Interaction as Potential New Anti-Cancer Therapy

Autor: Fariba Nemati, Narjesse Karboul, Fernando Roncal, Jerónimo Bravo, Issam Arrouss, Dominique Mazier, Didier Decaudin, Nathalie Rabbe, Marie Wislez, Karim Dorgham, Françoise Carlotti, Angelita Rebollo, David Vallerand

Publikováno v: PLoS ONE
PLoS ONE, 2013, 8 (4), pp.e60816. ⟨10.1371/journal.pone.0060816⟩
PLoS ONE, Public Library of Science, 2013, 8 (4), pp.e60816. ⟨10.1371/journal.pone.0060816⟩
Digital.CSIC. Repositorio Institucional del CSIC
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PLoS ONE, 8(4)
PLoS ONE, Vol 8, Iss 4, p e60816 (2013)

12 páginas, 6 figuras
Purpose: PP2A is a serine/threonine phosphatase critical to physiological processes, including apoptosis. Cell penetrating peptides are molecules that can translocate into cells without causing membrane damage. Our goal wa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c241544e860a270222ec4f02f69d3ab
https://hdl.handle.net/1887/96741