Výsledky vyhledávání - "David V. Tulumello"

Molecular Vehicles for Mitochondrial Chemical Biology and Drug Delivery

Autor: Sae Rin Jean, Simon Wisnovsky, Shana O. Kelley, Mark P. Pereira, Eric K. Lei, David V. Tulumello

Publikováno v: ACS Chemical Biology. 9:323-333

The mitochondria within human cells play a major role in a variety of critical processes involved in cell survival and death. An understanding of mitochondrial involvement in various human diseases has generated an appreciable amount of interest in e

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f6a0f4d919307ab292a6174710619d3
https://doi.org/10.1021/cb400821p

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Mitochondrial tyrosyl-DNA phosphodiesterase 2 and its TDP2

Autor: Shar-Yin N, Huang, Ilaria, Dalla Rosa, Stephanie A, Michaels, David V, Tulumello, Keli, Agama, Salim, Khiati, Sae Rin, Jean, Simone A, Baechler, Valentina M, Factor, Sudhir, Varma, Junko, Murai, Lisa M, Miller Jenkins, Shana O, Kelley, Yves, Pommier

Publikováno v: EMBO reports. 19(3)

Tyrosyl‐DNA phosphodiesterase 2 (TDP2) repairs abortive topoisomerase II cleavage complexes. Here, we identify a novel short isoform of TDP2 (TDP2(S)) expressed from an alternative transcription start site. TDP2(S) contains a mitochondrial targetin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::504372758a7d105b21a54b3fa9a671ae
https://pubmed.ncbi.nlm.nih.gov/29438979

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Design, expression, and purification of de novo transmembrane 'hairpin' peptides

Autor: David V. Tulumello, Rachel M. Johnson, Inga Isupov, Charles M. Deber

Publikováno v: Biopolymers. 98:546-556

While our understanding of the folding and structure of water-soluble proteins has progressed to the point where they can be artificially designed and produced from first principles, there has been only limited work toward the de novo design of membr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::153176fa306f58ad2fc4d304b7df8636
https://doi.org/10.1002/bip.22149

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Positions of Polar Amino Acids Alter Interactions between Transmembrane Segments and Detergents

Autor: David V. Tulumello, Charles M. Deber

Publikováno v: Biochemistry. 50:3928-3935

α-Helical transmembrane (TM) segments in membrane proteins are comprised primarily of hydrophobic amino acids that accommodate insertion from water into the nonpolar membrane bilayer. In many such segments, however, polar residues are also present f

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f32016cb66db34242ddeb05417ae876
https://doi.org/10.1021/bi200238g

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Peptide Models of Membrane Protein Folding

Autor: Charles M. Deber, Arianna Rath, David V. Tulumello

Publikováno v: Biochemistry. 48:3036-3045

Given the central roles of membrane proteins in cellular processes ranging from nutrient uptake to cell-cell communication, as well as the importance of these proteins as drug targets, efforts to understand and control their structures are vital in h

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87166a544a56beb4d33bcc066fc75abc
https://doi.org/10.1021/bi900184j

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Mitochondrial Targeting of Doxorubicin Eliminates Nuclear Effects Associated with Cardiotoxicity

Autor: Aaron D. Schimmer, Shana O. Kelley, Sanduni U. Liyanage, Chiara Riganti, David V. Tulumello, Sae Rin Jean

Publikováno v: ACS chemical biology. 10(9)

The highly effective anticancer agent doxorubicin (Dox) is a frontline drug used to treat a number of cancers. While Dox has a high level of activity against cancer cells, its clinical use is often complicated by dose-limiting cardiotoxicity. While t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ffe614466df906bbba097464dc0eb4d1
https://pubmed.ncbi.nlm.nih.gov/26038829

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Cellular Uptake of Substrate-Initiated Cell-Penetrating Poly(disulfide)s

Autor: Giulio Gasparini, Naomi Sakai, Stefan Matile, David V. Tulumello, Guillaume Molinard, Shana O. Kelley, Sandra Ward, Aurélien Roux, Eun Kyoung Bang

Publikováno v: Journal of the American Chemical Society, Vol. 136, No 16 (2014) pp. 6069-6074
J. Am. Chem. Soc.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Substrate-initiated, self-inactivating, cell-penetrating poly(disulfide)s (siCPDs) are introduced as general transporters for the covalent delivery of unmodified substrates of free choice. With ring-opening disulfide-exchange polymerization, we show

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c53c727581f9d4b38316c56a9480b2df
https://archive-ouverte.unige.ch/unige:36018

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Targeted delivery of doxorubicin to mitochondria

Autor: David V. Tulumello, Shana O. Kelley, Graham R. Chamberlain

Publikováno v: ACS chemical biology. 8(7)

Several families of highly effective anticancer drugs are selectively toxic to cancer cells because they disrupt nucleic acid synthesis in the nucleus. Much less is known, however, about whether interfering with nucleic acid synthesis in the mitochon

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8852562329bbce7234e2784b89cd896
https://pubmed.ncbi.nlm.nih.gov/23590228

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