Zobrazeno 1 - 10
of 139
pro vyhledávání: '"David V. Pow"'
Autor:
David V. Pow, Omar Šerý, Mohammed Abul Kashem, Caroline Rae, Vladimir J. Balcar, Benjamin D. Rowlands
Publikováno v:
Current Molecular Pharmacology. 14:138-149
We present an overview of genetic, metabolomic, proteomic and neurochemical studies done mainly in our laboratories that could improve prediction, mechanistic understanding and possibly extend to diagnostics and treatment of alcoholism and alcohol ad
Autor:
Pamela A. McCombe, Sarah Reed, James Aylward, David V. Pow, Aven Lee, Robert D. Henderson, Buddhika J. Arachchige
Publikováno v:
Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration. 22:206-210
D-serine is an endogenous co-agonist with glutamate for activation of the N-methyl-D-aspartate receptor (NMDAR). D-serine exacerbates neuronal death and is elevated in the spinal cord from patients...
Autor:
Hayden Alicajic, David V. Pow, Gilles J. Guillemin, Joseph A. Nicolazzo, Bruce J. Brew, Bat-Erdene Jugder, Nady Braidy, Jason R. Smith
Publikováno v:
Molecular Neurobiology. 58:34-54
In Alzheimer’s disease (AD), excessive amounts of quinolinic acid (QUIN) accumulate within the brain parenchyma and dystrophic neurons. QUIN also regulates glutamate uptake into neurons, which may be due to modulation of Na+-dependent excitatory am
Publikováno v:
Journal of Comparative Neurology. 528:3134-3142
Excitatory amino acid transporter 5 (EAAT5) is a protein that is known to be alternately spliced and to be abundantly expressed in the retina by populations of neurons including photoreceptors and bipolar cells. EAAT5 acts as a slow glutamate transpo
Publikováno v:
Handbook of Neurotoxicity ISBN: 9783031150791
Handbook of Neurotoxicity ISBN: 9781461458357
Handbook of Neurotoxicity ISBN: 9781461458357
Glutamate is the major excitatory neurotransmitter in the central nervous system and its levels in the synaptic cleft are tightly controlled by high affinity glutamate transporters (also known as Excitatory Amino Acid Transporters or EAATs). The EAAT
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0377406715e9ba7ff783298af073afc
https://doi.org/10.1007/978-3-031-15080-7_129
https://doi.org/10.1007/978-3-031-15080-7_129
Publikováno v:
Neurochemistry international. 125
We have analysed post-mortem samples of prefrontal cortex from control and alcoholic human brains by the technique of Western blotting to estimate and compare the expressions of glutamate transporter GLAST (Excitatory Amino Acid Transporter One; EAAT
Autor:
Helena C. Parkington, Natasha A. Boase, Harold A. Coleman, Philip Poronnik, Daria Camera, Trisha A. Jenkins, Sharad Kumar, David V. Pow
Publikováno v:
Behavioural Brain Research. 303:176-181
The consolidation of short-term memory into long-term memory involves changing protein level and activity for the synaptic plasticity required for long-term potentiation (LTP). AMPA receptor trafficking is a key determinant of LTP and recently ubiqui
Publikováno v:
Neurochemical Research. 40:2461-2472
Synaptically released L-glutamate, the most important excitatory neurotransmitter in the CNS, is removed from extracellular space by fast and efficient transport mediated by several transporters; the most abundant ones are EAAT1/GLAST and EAAT2/GLT1.
Publikováno v:
Medical hypotheses. 98
It has been known that a preconception paternal alcoholism impacts adversely on the offspring but the mechanism of the effect is uncertain. Several findings suggest that there are signalling systems in testis that are analogous to those known to be a
Publikováno v:
Gene. 506:283-288
Excitatory amino acid transporter 5 (EAAT5) is an unusual glutamate transporter that is expressed in the retina, where it is localised to two populations of glutamatergic neurons, namely the bipolar neurons and photoreceptors. EAAT5 exhibits two dist