Zobrazeno 1 - 10
of 14
pro vyhledávání: '"David V. Morrissey"'
Autor:
Jonathan D. Finn, Amy Rhoden Smith, Mihir C. Patel, Lucinda Shaw, Madeleine R. Youniss, Jane van Heteren, Tanner Dirstine, Corey Ciullo, Reynald Lescarbeau, Jessica Seitzer, Ruchi R. Shah, Aalok Shah, Dandan Ling, Jacqueline Growe, Melissa Pink, Ellen Rohde, Kristy M. Wood, William E. Salomon, William F. Harrington, Christian Dombrowski, Walter R. Strapps, Yong Chang, David V. Morrissey
Publikováno v:
Cell Reports, Vol 22, Iss 9, Pp 2227-2235 (2018)
Summary: The development of clinically viable delivery methods presents one of the greatest challenges in the therapeutic application of CRISPR/Cas9 mediated genome editing. Here, we report the development of a lipid nanoparticle (LNP)-mediated deliv
Externí odkaz:
https://doaj.org/article/f557a3a18840449b89062013d6e1f3ec
Autor:
Bruno M.D.C. Godinho, Melissa J. Moore, Anton A. Turanov, Anastasia Khvorova, David V. Morrissey, Neil Aronin, S. Ananth Karumanchi, Matthew R. Hassler, Dimas Echeverria, Julia F. Alterman, Loic Roux, William Salomon, Reka A. Haraszti, Mehran Nikan, Maire F. Osborn, Sarah M. Davis, Phillip D. Zamore, Andrew H. Coles
Publikováno v:
Nucleic Acids Research
Small interfering RNA (siRNA)-based drugs require chemical modifications or formulation to promote stability, minimize innate immunity, and enable delivery to target tissues. Partially modified siRNAs (up to 70% of the nucleotides) provide significan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3fc38e5be65b5e560d15cc391f103c7e
https://doi.org/10.1093/nar/gky037
https://doi.org/10.1093/nar/gky037
Autor:
Wood Kristy M, Corey Ciullo, William Salomon, Finn Jonathan Douglas, Amy Madison Rhoden Smith, Jacqueline Growe, Dandan Ling, Reynald Lescarbeau, Youniss Madeleine, David V. Morrissey, Jessica Seitzer, Ellen Rohde, Tanner Dirstine, Ruchi Rudraprasad Shah, Lucinda Shaw, Melissa Pink, Mihir Patel, Christian Dombrowski, Chang Yong, Jane van Heteren, Aalok Shah, William F. Harrington, Walter Strapps
Publikováno v:
Cell Reports, Vol 22, Iss 9, Pp 2227-2235 (2018)
Summary: The development of clinically viable delivery methods presents one of the greatest challenges in the therapeutic application of CRISPR/Cas9 mediated genome editing. Here, we report the development of a lipid nanoparticle (LNP)-mediated deliv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c0719aa81c3c1549aa7f9d9969ec3d6
http://www.sciencedirect.com/science/article/pii/S2211124718301827
http://www.sciencedirect.com/science/article/pii/S2211124718301827
Publikováno v:
Journal of Controlled Release. 172:699-706
Multidrug resistance (MDR) is a significant problem in the clinical management of several cancers. Overcoming MDR generally involves multi-modal therapeutic approaches that integrates enhancement of delivery efficiency using targeted nano-platforms a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd8e05e9dfaa7840708c1e85f2a287a9
https://doi.org/10.1016/j.jconrel.2013.10.016
https://doi.org/10.1016/j.jconrel.2013.10.016
Autor:
Mary J. Sever, Ian J. MacRae, Shane R. Horman, Paul R. Graves, Claudia Litterst, David V. Morrissey, Bingbing Wang, Loren Miraglia, Anthony P. Orth, Biao Luo, Carl D. Novina, Hank H. Qi, Maja M. Janas, Shaikamjad Umesalma
Publikováno v:
Molecular Cell. 50(3):356-367
A high-throughput RNA interference (RNAi) screen targeting 542 genes of the human kinome was used to discover regulators of RNAi. Here we report that the proto-oncogene Akt-3/PKBγ (Akt3) phosphorylates Argonaute 2 (Ago2) at S387, which downregulates
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b58e98e83e7152fc0a3b5a6084ef6021
Publikováno v:
Biomaterials. 34:3489-3502
Anticancer therapeutics employing RNA interference mechanism holds promising potentials for sequence-specific silencing of target genes. However targeted delivery of siRNAs to tumor tissues and cells and more importantly, their intracellular release
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b53bfc18723961c32bc8b7f86805100b
https://doi.org/10.1016/j.biomaterials.2013.01.077
https://doi.org/10.1016/j.biomaterials.2013.01.077
Autor:
Dominic Trojer, Nicole Meisner-Kober, Stefan von Bueren, Johannes Voshol, Katrin Martin, Wolf Heusermann, Justin Hean, Nicolas Pizzato, David V. Morrissey, Samir El Andaloussi, Christel Genoud, Alexandra Graff-Meyer, Emmanuelle Steib, Matthew J.A. Wood
Publikováno v:
The Journal of Cell Biology
Heusermann et al. use a single-vesicle dye-tracing analysis in live cells showing that exosomes enter cells as intact vesicles, primarily at filopodia-active regions, and sort into endocytic vesicle circuits that are targeted to scan the ER before be
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6cf52c401c5779d431dbf323feabc2c
http://hdl.handle.net/10044/1/83658
http://hdl.handle.net/10044/1/83658
Autor:
Lisa E. Young, David V. Morrissey, Nabanita De, Nicole-Claudia Meisner, Ian J. MacRae, Pick-Wei Lau
Argonaute proteins use small RNAs to guide the silencing of complementary target RNAs in many eukaryotes. Although small RNA biogenesis pathways are well studied, mechanisms for removal of guide RNAs from Argonaute are poorly understood. Here we show
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bddd088b5a23bded2cd169c8b2215e66
https://europepmc.org/articles/PMC3746828/
https://europepmc.org/articles/PMC3746828/
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 2, Iss C (2013)
Molecular Therapy. Nucleic Acids
Molecular Therapy. Nucleic Acids
One of the most challenging aspects of lung cancer therapy is the rapid acquisition of multidrug-resistant (MDR) phenotype. One effective approach would be to identify and downregulate resistance-causing genes in tumors using small interfering RNAs (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::910fbeb76c7b74b85ef7687b7f06c266
Autor:
Martin Hintersteiner, Justin Hean, Nicole Meisner-Kober, Florian Aeschimann, David V. Morrissey, Lukas Stalder, Pascal Basselet, Anja Fritzsche, Lena Sokol, Dominic Trojer, Vera Pfanzagl, Jan Weiler, Joel Wirz, Wolf Heusermann
Publikováno v:
The EMBO Journal
Despite progress in mechanistic understanding of the RNA interference (RNAi) pathways, the subcellular sites of RNA silencing remain under debate. Here we show that loading of lipid-transfected siRNAs and endogenous microRNAs (miRNA) into RISC (RNA-i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9f995fb5adc669836efa3da890120b1
https://pubmed.ncbi.nlm.nih.gov/23511973
https://pubmed.ncbi.nlm.nih.gov/23511973