Zobrazeno 1 - 10
of 22
pro vyhledávání: '"David V McLeod"'
Autor:
David V McLeod, Sylvain Gandon
Publikováno v:
eLife, Vol 10 (2021)
The evolution of multidrug resistance (MDR) is a pressing public health concern. Yet many aspects, such as the role played by population structure, remain poorly understood. Here, we argue that studying MDR evolution by focusing upon the dynamical eq
Externí odkaz:
https://doaj.org/article/705c0c1285c04a439f753ea423728585
Autor:
David V McLeod, Troy Day
Publikováno v:
PLoS Computational Biology, Vol 15, Iss 2, p e1006739 (2019)
How social traits such as altruism and spite evolve remains an open question in evolutionary biology. One factor thought to be potentially important is demographic stochasticity. Here we provide a general theoretical analysis of the role of demograph
Externí odkaz:
https://doaj.org/article/27853ce4e713480380751b2fa2a0d153
Publikováno v:
Evolution Letters
Evolution Letters, Vol 5, Iss 5, Pp 458-471 (2021)
Evolution Letters, Vol 5, Iss 5, Pp 458-471 (2021)
Although vaccination has been remarkably effective against some pathogens, for others, rapid antigenic evolution results in vaccination conferring only weak and/or short-lived protection. Consequently, considerable effort has been invested in develop
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0b0591d5a660a1f63068241117c206d
http://europepmc.org/articles/PMC8484727
http://europepmc.org/articles/PMC8484727
Autor:
David V. McLeod, Sylvain Gandon
Pathogen adaptation to public health interventions such as vaccination may take tortuous routes and involve multiple mutations at different locations in the pathogen genome, acting on distinct phenotypic traits. Yet how these multi-locus adaptations
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae02ec8768ab1ae9902f3d984aad1256
Autor:
David V, McLeod, Sylvain, Gandon
Publikováno v:
Nature ecologyevolution. 6(6)
Pathogen adaptation to public health interventions such as vaccination may take tortuous routes and involve multiple mutations at different locations in the pathogen genome, acting on distinct phenotypic traits. Yet how these multi-locus adaptations
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::6672d63c2d73e3ab8b0ab393bd9c82e4
https://pubmed.ncbi.nlm.nih.gov/35437005
https://pubmed.ncbi.nlm.nih.gov/35437005
Autor:
Sylvain Gandon, David V. McLeod
Publikováno v:
eLife
eLife, eLife Sciences Publication, 2021, 10, ⟨10.7554/eLife.65645⟩
eLife, eLife Sciences Publication, 2021, 10, pp.e65645. ⟨10.7554/eLife.65645⟩
eLife, Vol 10 (2021)
eLife, eLife Sciences Publication, 2021, 10, ⟨10.7554/eLife.65645⟩
eLife, eLife Sciences Publication, 2021, 10, pp.e65645. ⟨10.7554/eLife.65645⟩
eLife, Vol 10 (2021)
The evolution of multidrug resistance (MDR) is a pressing public health concern. Yet many aspects, such as the role played by population structure, remain poorly understood. Here we argue that studying MDR evolution by focusing upon the dynamical equ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22a6f92f9dbb728fc5329feb23c38ac4
https://hal.archives-ouvertes.fr/hal-03448142
https://hal.archives-ouvertes.fr/hal-03448142
Autor:
Troy Day, David V. McLeod
Publikováno v:
Evolution. 73:872-882
Sterility virulence, or the reduction in host fecundity due to infection, occurs in many host-pathogen systems. Notably, sterility virulence is more common for sexually transmitted infections (STIs) than for directly transmitted pathogens, while othe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61dacddd929770a8d265141385f296e5
https://doi.org/10.1111/evo.13718
https://doi.org/10.1111/evo.13718
Publikováno v:
Biology Publications
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Nature Communications, 12 (1)
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Nature Communications, 12 (1)
Nature Communications
Genes with identical DNA sequence may show differential expression because of epigenetic marks. Where epigenetic marks respond to past conditions, they represent a form of “memory”. Despite their medical relevance, the impact of memories on the e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3791c94f8490a2785a136faafb70a13c
Genes with identical DNA sequences may show differential expression because of epigenetic marks. These marks in pathogens are key to their virulence and are being evaluated as targets for medical treatment. Where epigenetic marks were created in resp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2130964295b6333d65c41ccaa77f4d08
https://doi.org/10.1101/2020.08.29.273326
https://doi.org/10.1101/2020.08.29.273326