Zobrazeno 1 - 10
of 26
pro vyhledávání: '"David V Erbe"'
Autor:
Tracy L McGregor, Karen A Hunt, Elaine Yee, Dan Mason, Paul Nioi, Simina Ticau, Marissa Pelosi, Perry R Loken, Sarah Finer, Deborah A Lawlor, Eric B Fauman, Qin Qin Huang, Christopher J Griffiths, Daniel G MacArthur, Richard C Trembath, Devin Oglesbee, John C Lieske, David V Erbe, John Wright, David A van Heel
Publikováno v:
eLife, Vol 9 (2020)
By sequencing autozygous human populations, we identified a healthy adult woman with lifelong complete knockout of HAO1 (expected ~1 in 30 million outbred people). HAO1 (glycolate oxidase) silencing is the mechanism of lumasiran, an investigational R
Externí odkaz:
https://doaj.org/article/ccbbccdcb771471c98bfa8da8d56bd48
Publikováno v:
PPAR Research, Vol 2008 (2008)
Externí odkaz:
https://doaj.org/article/0c6869dc8f964146803cb7bfc71191bf
Autor:
Mark Stahl, David V. Erbe, Yan-Ling Zhang, James Tobin, Xiaotian Zhong, Ron Kriz, Zheni Gjoka, Vipin Suri, Wayne Stochaj, Yuanhong Li
Publikováno v:
Archives of Biochemistry and Biophysics. 483:45-54
Tissue specific amplification of glucocorticoid action through NADPH-dependent reduction of inactive glucocorticoid precursors by 11beta-hydroxysteroid dehydrogenase (11beta-HSD1) contributes to the development of visceral obesity, insulin resistance
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::250c3463a9419817e27cb12536473b79
https://doi.org/10.1016/j.abb.2008.12.004
https://doi.org/10.1016/j.abb.2008.12.004
Autor:
Bruce Follows, Steve J. Kirincich, Jinbo Lee, Douglas P. Wilson, Diane Joseph-McCarthy, David V. Erbe, James Tobin, Yan-Ling Zhang, Tam Steve Yik-Kai, Zhao-Kui Wan, Eva Binnun, Wei Li, Rajeev Hotchandani, Junjun Wu, Tarek S. Mansour, Weixin Xu, Manus Ipek, May Tam, Alessandro Moretto
Publikováno v:
ChemMedChem. 3:1525-1529
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ffcda3d3c8bc8bbf5383b8dbeacb55c6
https://doi.org/10.1002/cmdc.200800188
https://doi.org/10.1002/cmdc.200800188
Autor:
Jinbo Lee, Junjun Wu, Yan-Ling Zhang, Zhao-Kui Wan, May Tam, David V. Erbe, Doug Wilson, James Tobin, Steven J. Kirincich
Publikováno v:
Analytical Biochemistry. 365:174-184
Considerable effort exists within drug discovery to develop novel compounds to improve the underlying metabolic defects in type 2 diabetes. One approach is focused on inhibition of the tyrosine phosphatase, PTP1B, an important negative regulator of b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14b71a84a20f55de6f9234bb30d59fd4
https://doi.org/10.1016/j.ab.2007.03.032
https://doi.org/10.1016/j.ab.2007.03.032
Autor:
Yan-Ling Zhang, Zhao-Kui Wan, Eddine Saiah, David V. Erbe, Tam Steve Yik-Kai, Junjun Wu, Eva Binnun, May Tam, Diane Joseph-McCarthy, Jinbo Lee, Steven J. Kirincich, Weixin Xu, Bruce Follows, Michael F. Smith, Douglas P. Wilson
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 17:2913-2920
The following account describes our systematic effort to replace one of the carboxylate groups of our diacid thiophene PTP1B inhibitors. Active hits were validated using enzymatic assays before pursuing efforts to improve the potency. Only when the C
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8375221dff5ff2459ed691b307797e01
https://doi.org/10.1016/j.bmcl.2007.02.043
https://doi.org/10.1016/j.bmcl.2007.02.043
Autor:
Bruce Follows, Yan-Ling Zhang, Zhao-Kui Wan, David V. Erbe, Diane Joseph-McCarthy, Weixin Xu, Jinbo Lee
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 16:4941-4945
A series of monocyclic thiophenes was designed and synthesized as PTP1B inhibitors. Guided by X-ray co-crystal structural information and computational modeling, rational design led to key interactions with Asp48 and improved inhibitory potency again
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ac1d718b16ea481a5e29ae34be6110c
https://doi.org/10.1016/j.bmcl.2006.06.051
https://doi.org/10.1016/j.bmcl.2006.06.051
Autor:
Suyue Wang, Steven J. Kirincich, Sarah Will, David V. Erbe, Yan-Ling Zhang, James Tobin, Katherine Gartrell, Vipin Suri, Mylene Perreault
Publikováno v:
Vascular Pharmacology. 45:154-162
OBJECTIVE AND DESIGN Elevated blood pressure and insulin resistance are strongly associated in patients. We explored the potential for the anti-hypertensive angiotensin II type 1-receptor (ATR(1)) antagonists to improve insulin sensitivity through mo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e7ed93615d6888683e2c50173d71536
https://doi.org/10.1016/j.vph.2006.05.002
https://doi.org/10.1016/j.vph.2006.05.002
Autor:
Kenneth W. Foreman, David V. Erbe, Yan-Ling Zhang, Steven J. Kirincich, Zhao-Kui Wan, Alessandro Moretto, Eva Binnun, Douglas P. Wilson, Tam Steve Yik-Kai, S.K. Tam, Bruce Follows, Weixin Xu, Diane Joseph-McCarthy, Julie Lee, Michael J. Smith
Publikováno v:
Bioorganic & Medicinal Chemistry. 14:2162-2177
A novel pyridothiophene inhibitor of PTP1B was discovered by rational screening of phosphotyrosine mimics at high micromolar concentrations. The potency of this lead compound has been improved significantly by medicinal chemistry guided by X-ray crys
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4f3ea9825417e657d8eab4182b3f9bb
https://doi.org/10.1016/j.bmc.2005.11.005
https://doi.org/10.1016/j.bmc.2005.11.005