Zobrazeno 1 - 10
of 20
pro vyhledávání: '"David Unnersjö Jess"'
Autor:
Eva Wiesner, Julia Binz-Lotter, Agnes Hackl, David Unnersjö-Jess, Nelli Rutkowski, Thomas Benzing, Matthias J. Hackl
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-10 (2024)
Abstract In recent years functional multiphoton (MP) imaging of vital mouse tissues and stimulation emission depletion (STED) imaging of optically cleared tissues allowed new insights into kidney biology. Here, we present a novel workflow where MP im
Externí odkaz:
https://doaj.org/article/7f01487f736845bebb0684e500ef792b
Autor:
Egle Kvedaraite, Magda Lourda, Natalia Mouratidou, Tim Düking, Avinash Padhi, Kirsten Moll, Paulo Czarnewski, Indranil Sinha, Ioanna Xagoraris, Efthymia Kokkinou, Anastasios Damdimopoulos, Whitney Weigel, Olga Hartwig, Telma E. Santos, Tea Soini, Aline Van Acker, Nelly Rahkonen, Malin Flodström Tullberg, Emma Ringqvist, Marcus Buggert, Carl Jorns, Ulrik Lindforss, Caroline Nordenvall, Christopher T. Stamper, David Unnersjö-Jess, Mira Akber, Ruta Nadisauskaite, Jessica Jansson, Niels Vandamme, Chiara Sorini, Marijke Elise Grundeken, Helena Rolandsdotter, George Rassidakis, Eduardo J. Villablanca, Maja Ideström, Stefan Eulitz, Henrik Arnell, Jenny Mjösberg, Jan-Inge Henter, Mattias Svensson
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract Stromal cells support epithelial cell and immune cell homeostasis and play an important role in inflammatory bowel disease (IBD) pathogenesis. Here, we quantify the stromal response to inflammation in pediatric IBD and reveal subset-specific
Externí odkaz:
https://doaj.org/article/4dc18c7a87ab47da922abb5a03ceaf68
Autor:
Thomas Schömig, Paul Diefenhardt, Ingo Plagmann, Bastian Trinsch, Tim Merz, Giuliano Crispatzu, David Unnersjö-Jess, Jasper Nies, David Pütz, Claudio Sierra Gonzalez, Bernhard Schermer, Thomas Benzing, Paul Thomas Brinkkoetter, Sebastian Brähler
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-12 (2024)
Abstract Podocytes form the kidney filtration barrier and continuously adjust to external stimuli to preserve their integrity even in the presence of inflammation. It was suggested that canonical toll-like receptor signaling, mediated by the adaptor
Externí odkaz:
https://doaj.org/article/9876ddb5e0934f8d8f9d9a648f58c3d3
Autor:
Linus Butt, David Unnersjö-Jess, Dervla Reilly, Robert Hahnfeldt, Markus M. Rinschen, Katarzyna Bozek, Bernhard Schermer, Thomas Benzing, Martin Höhne
Publikováno v:
BMC Nephrology, Vol 24, Iss 1, Pp 1-14 (2023)
Abstract The most common genetic causes of steroid-resistant nephrotic syndrome (SRNS) are mutations in the NPHS2 gene, which encodes the cholesterol-binding, lipid-raft associated protein podocin. Mass spectrometry and cDNA sequencing revealed the e
Externí odkaz:
https://doaj.org/article/0724fc4b52414f4ba1addf3e1cc01f23
Autor:
Emmanuelle Charrin, Dina Dabaghie, Ilke Sen, David Unnersjö-Jess, Katja Möller-Hackbarth, Mikhail Burmakin, Rik Mencke, Sonia Zambrano, Jaakko Patrakka, Hannes Olauson
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-16 (2023)
Transgenic overexpression of αKlotho in hepatocytes results in protection against renal insults, possibly through modulation of the ER stress response by circulating αKlotho. In contrast, αKlotho overexpressed in podocytes is not renoprotective.
Externí odkaz:
https://doaj.org/article/619b3e82d9e24b86ae6db800031da9d4
Autor:
Bing He, Ping Chen, Sonia Zambrano, Dina Dabaghie, Yizhou Hu, Katja Möller-Hackbarth, David Unnersjö-Jess, Gül Gizem Korkut, Emmanuelle Charrin, Marie Jeansson, Maria Bintanel-Morcillo, Anna Witasp, Lars Wennberg, Annika Wernerson, Bernhard Schermer, Thomas Benzing, Patrik Ernfors, Christer Betsholtz, Mark Lal, Rickard Sandberg, Jaakko Patrakka
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-19 (2021)
The molecular identity of renal glomerular cells is poorly characterized and rodent glomerulopathy models translate poorly to humans. Here, the authors show molecular signatures of glomerulus-associated cells using single cell RNA sequencing and high
Externí odkaz:
https://doaj.org/article/fe04160ada134a20a0af7aef65e1f106
Autor:
David Unnersjö-Jess, Amer Ramdedovic, Linus Butt, Ingo Plagmann, Martin Höhne, Agnes Hackl, Hans Blom, Bernhard Schermer, Thomas Benzing
Mammalian kidneys filter enormous volumes of water and small solutes, a filtration driven by the very high hydrostatic pressure in glomerular capillaries. Interdigitating cellular processes of podocytes form the slits for fluid filtration. They are c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c1946867bc3861b5ffaebbdc724f9692
https://doi.org/10.1101/2023.02.10.528006
https://doi.org/10.1101/2023.02.10.528006
Autor:
Hjalmar Brismar, Bernhard Schermer, David Unnersjö-Jess, Paul Brinkkötter, Robert Hahnfeldt, Markus Rinschen, Hans Blom, Sebastian Braehler, Ingo Plagmann, Paul Diefenhardt, Linus Butt, Thomas Benzing, Martin Höhne, Dervla Reilly
Publikováno v:
J Am Soc Nephrol
Butt, L, Unnersjö-Jess, D, Höhne, M, Hahnfeldt, R, Reilly, D, Rinschen, M, Plagmann, I, Diefenhardt, P, Braehler, S, Brinkkötter, P, Brismar, H, Blom, H, Schermer, B & Benzing, T 2022, ' Super-Resolution Imaging of the Filtration Barrier Suggests a Role for Podocin R229Q in Genetic Predisposition to Glomerular Disease ', Journal of the American Society of Nephrology : JASN, vol. 33, no. 1, pp. 138-154 . https://doi.org/10.1681/ASN.2020060858
Butt, L, Unnersjö-Jess, D, Höhne, M, Hahnfeldt, R, Reilly, D, Rinschen, M, Plagmann, I, Diefenhardt, P, Braehler, S, Brinkkötter, P, Brismar, H, Blom, H, Schermer, B & Benzing, T 2022, ' Super-Resolution Imaging of the Filtration Barrier Suggests a Role for Podocin R229Q in Genetic Predisposition to Glomerular Disease ', Journal of the American Society of Nephrology : JASN, vol. 33, no. 1, pp. 138-154 . https://doi.org/10.1681/ASN.2020060858
Background Diseases of the kidney's glomerular filtration barrier are a leading cause of end-stage renal failure. Despite of a growing understanding of genes involved in glomerular disorders in children, the vast majority of adult patients lack a cle
Autor:
Sybille Koehler, Johanna Odenthal, Vivian Ludwig, David Unnersjö Jess, Martin Höhne, Christian Jüngst, Ferdi Grawe, Martin Helmstädter, Johanna L. Janku, Carsten Bergmann, Peter F. Hoyer, H. Henning Hagmann, Gerd Walz, Wilhelm Bloch, Carien Niessen, Bernhard Schermer, Andreas Wodarz, Barry Denholm, Thomas Benzing, Sandra Iden, Paul T. Brinkkoetter
Glomerular diseases are a major cause for chronic kidney disorders. In most cases podocyte injury is causative for disease development. Cytoskeletal rearrangements and morphological changes are hallmark features of podocyte injury and result in dedif
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0538911a3b27623d4945e1c7b0ae709
https://www.ncbi.nlm.nih.gov/pubmed/34929254
https://www.ncbi.nlm.nih.gov/pubmed/34929254
Publikováno v:
The FASEB Journal
The central role of calcium signaling during development of early vertebrates is well documented, but little is known about its role in mammalian embryogenesis. We have used immunofluorescence and time-lapse calcium imaging of cultured explanted embr