Zobrazeno 1 - 10
of 34
pro vyhledávání: '"David Tyssen"'
Autor:
David Jose Delgado-Diaz, Brianna Jesaveluk, Joshua A. Hayward, David Tyssen, Arghavan Alisoltani, Matthys Potgieter, Liam Bell, Elizabeth Ross, Arash Iranzadeh, Imane Allali, Smritee Dabee, Shaun Barnabas, Hoyam Gamieldien, Jonathan M. Blackburn, Nicola Mulder, Steven B. Smith, Vonetta L. Edwards, Adam D. Burgener, Linda-Gail Bekker, Jacques Ravel, Jo-Ann S. Passmore, Lindi Masson, Anna C. Hearps, Gilda Tachedjian
Publikováno v:
Microbiome, Vol 10, Iss 1, Pp 1-16 (2022)
Abstract Background Women with a cervicovaginal microbiota dominated by Lactobacillus spp. are at reduced risk of acquiring sexually transmitted infections including HIV, but the biological mechanisms involved remain poorly defined. Here, we performe
Externí odkaz:
https://doaj.org/article/0541f19108804ca5b9410ea97a642ff7
Autor:
David Tyssen, Anna C. Hearps, Kalyani Guntur, Lindi Masson, Simon Cook, Simon E. Moulton, Jacques Ravel, Catriona S. Bradshaw, Seyoum Ayehunie, Gilda Tachedjian
Publikováno v:
Frontiers in Reproductive Health, Vol 4 (2022)
The vaginal microbiome influences a wide range of health outcomes in women, where a microbiome dominated by Lactobacillus spp. is considered optimal and associated with reduced risk of pre-term birth and acquisition of sexually transmitted infections
Externí odkaz:
https://doaj.org/article/f729ddbc875949eda849d2ea7651b75b
Autor:
Mahta Mansouri, Shawn Rumrill, Shane Dawson, Adam Johnson, Jo-Anne Pinson, Menachem J. Gunzburg, Catherine F. Latham, Nicholas Barlow, George W. Mbogo, Paula Ellenberg, Stephen J. Headey, Nicolas Sluis-Cremer, David Tyssen, Joseph D. Bauman, Francesc X. Ruiz, Eddy Arnold, David K. Chalmers, Gilda Tachedjian
Publikováno v:
Molecules, Vol 28, Iss 7, p 3103 (2023)
Human immunodeficiency virus type I (HIV-1) is a retrovirus that infects cells of the host’s immune system leading to acquired immunodeficiency syndrome and potentially death. Although treatments are available to prevent its progression, HIV-1 rema
Externí odkaz:
https://doaj.org/article/c7cd4c19945d4662b4ccbad1fae4b33e
Autor:
David J. Delgado-Diaz, David Tyssen, Joshua A. Hayward, Raffi Gugasyan, Anna C. Hearps, Gilda Tachedjian
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 9 (2020)
Non-optimal vaginal microbiota, as observed in bacterial vaginosis (BV), is typically characterized by a depletion of beneficial lactobacilli and an abundance of numerous anaerobes. These non-optimal conditions are associated with subclinical cervico
Externí odkaz:
https://doaj.org/article/ed77aa6f49114302b9a8b34c6de10bb0
Autor:
David Tyssen, Ying-Ying Wang, Joshua A. Hayward, Paul A. Agius, Kevin DeLong, Muriel Aldunate, Jacques Ravel, Thomas R. Moench, Richard A. Cone, Gilda Tachedjian
Publikováno v:
mSphere, Vol 3, Iss 4 (2018)
ABSTRACT Women of reproductive age with a Lactobacillus-dominated vaginal microbiota have a reduced risk of acquiring and transmitting HIV and a vaginal pH of ~4 due to the presence of ~1% (wt/vol) lactic acid. While lactic acid has potent HIV viruci
Externí odkaz:
https://doaj.org/article/80b414df21a043c5a01f64c330c1b08f
Autor:
Clare F Price, David Tyssen, Secondo Sonza, Ashley Davie, Sonya Evans, Gareth R Lewis, Shirley Xia, Tim Spelman, Peter Hodsman, Thomas R Moench, Andrew Humberstone, Jeremy R A Paull, Gilda Tachedjian
Publikováno v:
PLoS ONE, Vol 6, Iss 9, p e24095 (2011)
UnlabelledSPL7013 Gel (VivaGel(®)) is a microbicide in development for prevention of HIV and HSV. This clinical study assessed retention and duration of antiviral activity following vaginal administration of 3% SPL7013 Gel in healthy women. Particip
Externí odkaz:
https://doaj.org/article/bdfe8b68946e44cf931a6d338a6ecc77
Autor:
David Tyssen, Scott A Henderson, Adam Johnson, Jasminka Sterjovski, Katie Moore, Jennifer La, Mark Zanin, Secondo Sonza, Peter Karellas, Michael P Giannis, Guy Krippner, Steve Wesselingh, Tom McCarthy, Paul R Gorry, Paul A Ramsland, Richard Cone, Jeremy R A Paull, Gareth R Lewis, Gilda Tachedjian
Publikováno v:
PLoS ONE, Vol 5, Iss 8, p e12309 (2010)
Topical microbicides, used by women to prevent the transmission of HIV and other sexually transmitted infections are urgently required. Dendrimers are highly branched nanoparticles being developed as microbicides. However, the anti-HIV and HSV struct
Externí odkaz:
https://doaj.org/article/8e209eef94d84445b4f108cdfa4f797f
Autor:
Soo-Huey Yap, Chih-Wei Sheen, Jonathan Fahey, Mark Zanin, David Tyssen, Viviane Dias Lima, Brian Wynhoven, Michael Kuiper, Nicolas Sluis-Cremer, P Richard Harrigan, Gilda Tachedjian
Publikováno v:
PLoS Medicine, Vol 4, Iss 12, p e335 (2007)
The catalytically active 66-kDa subunit of the human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT) consists of DNA polymerase, connection, and ribonuclease H (RNase H) domains. Almost all known RT inhibitor resistance mutations ide
Externí odkaz:
https://doaj.org/article/fcd5f963140d4945a830882ea6f0b736
Autor:
Nathania Leong, David Tyssen, Gilda Tachedjian, Charlotte C. Williams, Christopher J.H. Porter, Orlagh M. Feeney, David B. Ascher, Lisa M. Kaminskas, Linda J. Chan, Neville J. Butcher
Publikováno v:
European Journal of Pharmaceutics and Biopharmaceutics. 137:218-226
HIV therapy with anti-retroviral drugs is limited by the poor exposure of viral reservoirs, such as lymphoid tissue, to these small molecule drugs. We therefore investigated the effect of PEGylation on the anti-retroviral activity and subcutaneous ly
Autor:
Anna C. Hearps, David Tyssen, Raffi Gugasyan, Deborah J. Anderson, L Bayigga, Gilda Tachedjian, D Srbinovski, R A Cone, Muriel Aldunate, D J D Diaz
Publikováno v:
Mucosal Immunology. 10:1480-1490
Inflammation in the female reproductive tract (FRT) is associated with increased HIV transmission. Lactobacillus spp. dominate the vaginal microbiota of many women and their presence is associated with reduced HIV acquisition. Here we demonstrate tha