Zobrazeno 1 - 10
of 377
pro vyhledávání: '"David Tse"'
Autor:
Thomas A. Strong, Juan Esquivel, Qikai Wang, Paul J. Ledon, Hua Wang, Gabriel Gaidosh, David Tse, Daniel Pelaez
Publikováno v:
Eye and Vision, Vol 10, Iss 1, Pp 1-17 (2023)
Abstract Background Optic neuropathy is a major cause of irreversible blindness, yet the molecular determinants that contribute to neuronal demise have not been fully elucidated. Several studies have identified ‘ephrin signaling’ as one of the mo
Externí odkaz:
https://doaj.org/article/4b39e490606d4f77afc6114f3e4c9d87
Autor:
Clarus Leung, Min Hyung Ryu, Anette Kocbach Bølling, Danay Maestre-Batlle, Christopher F. Rider, Anke Hüls, Oscar Urtatiz, Julie L. MacIsaac, Kevin Soon-Keen Lau, David Tse Shen Lin, Michael S. Kobor, Chris Carlsten
Publikováno v:
Respiratory Research, Vol 23, Iss 1, Pp 1-10 (2022)
Abstract Background Single nucleotide polymorphisms (SNPs) of peroxisome proliferator-activated receptor gamma (PPAR-γ; gene: PPARG) and oxidative stress genes are associated with asthma risk. However, whether such variants modulate responses to dib
Externí odkaz:
https://doaj.org/article/b68df42a54c3478aac04f4e497660015
Autor:
Jia-Ling Chou, David Tse
Publikováno v:
Case Reports in Oncology, Vol 14, Iss 2, Pp 1254-1260 (2021)
Primary mediastinal nonseminomatous germ cell tumor with extrathoracic metastases is associated with a very high mortality rate, and there is no consensus regarding optimal upfront therapy. Once patients fail the first-line treatment, salvage therapy
Externí odkaz:
https://doaj.org/article/c956e1e23a644fd186b91dc9de7e9d22
Autor:
Sarah Rose Moore, Kathryn Leigh Humphreys, Natalie Lisanne Colich, Elena Goetz Davis, David Tse Shen Lin, Julia Lynn MacIsaac, Michael Steffen Kobor, Ian Henry Gotlib
Publikováno v:
BMC Genomics, Vol 21, Iss 1, Pp 1-16 (2020)
Abstract Background There are significant sex differences in human physiology and disease; the genomic sources of these differences, however, are not well understood. During puberty, a drastic neuroendocrine shift signals physical changes resulting i
Externí odkaz:
https://doaj.org/article/f438568a75a5437dba7c50bdf58ff474
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
For single-cell RNA-seq experiments the sequencing budget is limited, and how it should be optimally allocated to maximize information is not clear. Here the authors develop a mathematical framework to show that, for estimating many gene properties,
Externí odkaz:
https://doaj.org/article/eb7cd4d5fdbd475eadea665c0731525d
Autor:
Rym Ben-Othman, Bing Cai, Aaron C. Liu, Natallia Varankovich, Daniel He, Travis M. Blimkie, Amy H. Lee, Erin E. Gill, Mark Novotny, Brian Aevermann, Sibyl Drissler, Casey P. Shannon, Sarah McCann, Kim Marty, Gordean Bjornson, Rachel D. Edgar, David Tse Shen Lin, Nicole Gladish, Julia Maclsaac, Nelly Amenyogbe, Queenie Chan, Alba Llibre, Joyce Collin, Elise Landais, Khoa Le, Samantha M. Reiss, Wayne C. Koff, Colin Havenar-Daughton, Manraj Heran, Bippan Sangha, David Walt, Mel Krajden, Shane Crotty, Devin Sok, Bryan Briney, Dennis R. Burton, Darragh Duffy, Leonard J. Foster, William W. Mohn, Michael S. Kobor, Scott J. Tebbutt, Ryan R. Brinkman, Richard H. Scheuermann, Robert E. W. Hancock, Tobias R. Kollmann, Manish Sadarangani
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Conventional vaccine design has been based on trial-and-error approaches, which have been generally successful. However, there have been some major failures in vaccine development and we still do not have highly effective licensed vaccines for tuberc
Externí odkaz:
https://doaj.org/article/161a4130886644838de4892cc5710d1d
Publikováno v:
PLoS ONE, Vol 15, Iss 6, p e0232946 (2020)
High throughput sequencing of RNA (RNA-Seq) has become a staple in modern molecular biology, with applications not only in quantifying gene expression but also in isoform-level analysis of the RNA transcripts. To enable such an isoform-level analysis
Externí odkaz:
https://doaj.org/article/3acb59245c7d400fbb7ff84962cfccc3
Autor:
Lisa M McEwen, Meaghan J Jones, David Tse Shen Lin, Rachel D Edgar, Lucas T Husquin, Julia L MacIsaac, Katia E Ramadori, Alexander M Morin, Christopher F Rider, Chris Carlsten, Lluís Quintana-Murci, Steve Horvath, Michael S Kobor
Publikováno v:
Clinical Epigenetics, Vol 10, Iss 1, Pp 1-9 (2018)
Abstract Background The capacity of technologies measuring DNA methylation (DNAm) is rapidly evolving, as are the options for applicable bioinformatics methods. The most commonly used DNAm microarray, the Illumina Infinium HumanMethylation450 (450K a
Externí odkaz:
https://doaj.org/article/c7c9511d89d7403dbd78d2c6ae04b322
Publikováno v:
International Journal of Abdominal Wall and Hernia Surgery, Vol 1, Iss 2, Pp 66-68 (2018)
Morgagni hernias are a rare finding in the adult population and represent 1%–3% of all congenital diaphragmatic hernias. Multiple approaches to these rare hernias have been described in the literature. Here, we present a novel technique of laparosc
Externí odkaz:
https://doaj.org/article/f875c3ab24b34be7891b3bc1f9007bb2
Publikováno v:
PLoS ONE, Vol 14, Iss 5, p e0197949 (2019)
Immunotherapy has recently shown important clinical successes in a substantial number of oncology indications. Additionally, the tumor somatic mutation load has been shown to associate with response to these therapeutic agents, and specific mutationa
Externí odkaz:
https://doaj.org/article/523f2d429ec84eb9aadc0b4614fb7579