Zobrazeno 1 - 10
of 161
pro vyhledávání: '"David Tosh"'
Autor:
Mugdha V. Joglekar, Subhshri Sahu, Wilson K.M. Wong, Sarang N. Satoor, Charlotte X. Dong, Ryan J. Farr, Michael D. Williams, Prapti Pandya, Gaurang Jhala, Sundy N.Y. Yang, Yi Vee Chew, Nicola Hetherington, Dhan Thiruchevlam, Sasikala Mitnala, Guduru V. Rao, Duvvuru Nageshwar Reddy, Thomas Loudovaris, Wayne J. Hawthorne, Andrew G. Elefanty, Vinay M. Joglekar, Edouard G. Stanley, David Martin, Helen E. Thomas, David Tosh, Louise T. Dalgaard, Anandwardhan A. Hardikar
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 13, Iss 5, Pp 1530-1553.e4 (2022)
Background & Aims: Pancreatic islet β-cells are factories for insulin production; however, ectopic expression of insulin also is well recognized. The gallbladder is a next-door neighbor to the developing pancreas. Here, we wanted to understand if ga
Externí odkaz:
https://doaj.org/article/3d728a223a8941f1b6deb7467c5a4e8a
Autor:
Mafalda Ribeiro, Aya Elghajiji, Scott P. Fraser, Zoë D. Burke, David Tosh, Mustafa B. A. Djamgoz, Paulo R. F. Rocha
Publikováno v:
Frontiers in Neuroscience, Vol 14 (2020)
Breast cancer is one of the most prevalent types of cancers worldwide and yet, its pathophysiology is poorly understood. Single-cell electrophysiological studies have provided evidence that membrane depolarization is implicated in the proliferation a
Externí odkaz:
https://doaj.org/article/44aada60764e4dd1ab1f66ef1045542e
Autor:
Francis D. Gratte, Sara Pasic, John K. Olynyk, George C. T. Yeoh, David Tosh, Deirdre R. Coombe, Janina E. E. Tirnitz-Parker
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-13 (2018)
Abstract The rising prevalence of chronic liver disease, coupled with a permanent shortage of organs for liver transplantation, has sparked enormous interest in alternative treatment strategies. Previous protocols to generate hepatocyte-like cells (H
Externí odkaz:
https://doaj.org/article/1c6f068c1e694afea2169b275e22b469
Autor:
Amani Al-Adsani, Zoë D Burke, Daniel Eberhard, Katherine L Lawrence, Chia-Ning Shen, Anil K Rustgi, Hiroshi Sakaue, J Mark Farrant, David Tosh
Publikováno v:
PLoS ONE, Vol 14, Iss 7, p e0219419 (2019)
[This corrects the article DOI: 10.1371/journal.pone.0013650.].
Externí odkaz:
https://doaj.org/article/edcc634b4f6541bd982ad2a9cd4c8508
Autor:
Michael P Storm, Benjamin Kumpfmueller, Heather K Bone, Michael Buchholz, Yolanda Sanchez Ripoll, Julian B Chaudhuri, Hitoshi Niwa, David Tosh, Melanie J Welham
Publikováno v:
PLoS ONE, Vol 9, Iss 3, p e89821 (2014)
The Zscan4 family of genes, encoding SCAN-domain and zinc finger-containing proteins, has been implicated in the control of early mammalian embryogenesis as well as the regulation of pluripotency and maintenance of genome integrity in mouse embryonic
Externí odkaz:
https://doaj.org/article/f115cb6f69d24f3da5d9fd63436dc30a
Autor:
Edward Carter, Gabriela Miron-Buchacra, Silvia Goldoni, Henry Danahay, John Westwick, Malcolm L Watson, David Tosh, Stephen G Ward
Publikováno v:
PLoS ONE, Vol 9, Iss 12, p e113555 (2014)
Branching morphogenesis is a critical step in the development of many epithelial organs. The phosphoinositide-3-kinase (PI3K) pathway has been identified as a central component of this process but the precise role has not been fully established. Here
Externí odkaz:
https://doaj.org/article/38d6a95452a54b9ca5345eb99a33bc87
Autor:
Amani Al-Adsani, Zoë D Burke, Daniel Eberhard, Katherine L Lawrence, Chia-Ning Shen, Anil K Rustgi, Hiroshi Sakaue, J Mark Farrant, David Tosh
Publikováno v:
PLoS ONE, Vol 5, Iss 10, p e13650 (2010)
BACKGROUND:The pancreatic exocrine cell line AR42J-B13 can be reprogrammed to hepatocytes following treatment with dexamethasone. The question arises whether dexamethasone also has the capacity to induce ductal cells as well as hepatocytes. METHODOLO
Externí odkaz:
https://doaj.org/article/a55eafc87a9d4e559fa6a81e0da14da7
Autor:
Michael Buchert, Dimitris Athineos, Helen E Abud, Zoe D Burke, Maree C Faux, Michael S Samuel, Andrew G Jarnicki, Catherine E Winbanks, Ian P Newton, Valerie S Meniel, Hiromu Suzuki, Steven A Stacker, Inke S Näthke, David Tosh, Joerg Huelsken, Alan R Clarke, Joan K Heath, Owen J Sansom, Matthias Ernst
Publikováno v:
PLoS Genetics, Vol 6, Iss 1, p e1000816 (2010)
Contributions of null and hypomorphic alleles of Apc in mice produce both developmental and pathophysiological phenotypes. To ascribe the resulting genotype-to-phenotype relationship unambiguously to the Wnt/beta-catenin pathway, we challenged the al
Externí odkaz:
https://doaj.org/article/c8728f803cb245d0b4062cdd15c9a522
Autor:
Suchitra Sumitran-Holgersson, Greg Nowak, Shifaan Thowfeequ, Setara Begum, Meghnad Joshi, Marie Jaksch, Anders Kjaeldgaard, Carl Jorns, Bo-Göran Ericzon, David Tosh
Publikováno v:
Cell Transplantation, Vol 18 (2009)
Although the appearance of hepatic foci in the pancreas has been described in animal experiments and in human pathology, evidence for the conversion of human pancreatic cells to liver cells is still lacking. We therefore investigated the developmenta
Externí odkaz:
https://doaj.org/article/bcb005ec1fea4464b63afddeeb8811f7
Publikováno v:
Canadian Journal of Learning and Technology, Vol 31, Iss 3 (2005)
Much of the evidence and research available on the use of e-portfolios focuses on faculty and institutional perspectives and/or consists mainly of anecdotes about how useful the e-portfolio has been to learners. While it is generally agreed that e-po
Externí odkaz:
https://doaj.org/article/cdc78aaad0f14a54bed83c4f7853662e