Zobrazeno 1 - 9
of 9
pro vyhledávání: '"David Tickle"'
Autor:
Alistair Mathie, Paul D. Wright, Jeffrey Jerman, David McCoull, David Tickle, Emma Ococks, Jonathan M. Large
Publikováno v:
Slas Discovery
Two-pore domain potassium (K2P) channels carry background (or leak) potassium current and play a key role in regulating resting membrane potential and cellular excitability. Accumulating evidence points to a role for K2Ps in human pathophysiologies,
Autor:
Gemma Gothard, David Tickle, Alistair Mathie, Jeffrey Jerman, Jonathan M. Large, Catherine A. Kettleborough, Emma L. Veale, Emma Ococks, Paul D. Wright, David McCoull
Two-pore domain potassium channels (K2Ps) are characterized by their four transmembrane domain and two-pore topology. They carry background (or leak) potassium current in a variety of cell types. Despite a number of important roles there is currently
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0a43febd3edbe7e1c1d12d7112608c0
Autor:
Emilie A. Bureau, Paul D. Wright, Laura De Conti, Marco Baralle, Janet Brownlees, Chido Mpamhanga, Catherine A. Kettleborough, Lucia Cragnaz, David Reynolds, David Tickle
Publikováno v:
Alzheimer's & Dementia. 13
Autor:
Jeff Jerman, Catherine A. Kettleborough, Gregory Weir, David Tickle, Jamie Cartland, M. Zameel Cader, Paul D. Wright
TRESK is a two-pore domain potassium channel. Loss of function mutations have been linked to typical migraine with aura and due to TRESK's expression pattern and role in neuronal excitability it represents a promising therapeutic target. We developed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::033bb38dc5dc9bc13aee2a2c1356bc1b
https://doi.org/10.1016/j.bbrc.2013.10.090
https://doi.org/10.1016/j.bbrc.2013.10.090
Autor:
Catherine A. Kettleborough, Conor McCloskey, Paul D. Wright, Nathalie Bouloc, David Tickle, Jamie Cartland, Derek J. Tresize, Srinivasan Kanumilli, Samantha McCavera, Andrew M. Blanks, Jeffrey Jerman, Timothy Dale
Publikováno v:
Journal of biomolecular screening. 20(6)
Kir7.1 is an inwardly rectifying potassium channel that has been implicated in controlling the resting membrane potential of the myometrium. Abnormal uterine activity in pregnancy plays an important role in postpartum hemorrhage, and novel therapies
Autor:
David Tickler, Jessica J. Meeuwig, Katharine Bryant, Fiona David, John A. H. Forrest, Elise Gordon, Jacqueline Joudo Larsen, Beverly Oh, Daniel Pauly, Ussif R. Sumaila, Dirk Zeller
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-9 (2018)
There have been growing concerns about the exploitation of workers in the fisheries sectors. Here, Tickler et al. use a country-level metric of slavery to determine the risk of fisheries-level slavery across 20 countries, and find it rises as unrepor
Externí odkaz:
https://doaj.org/article/d8210a9dfd5a409182e7a6829354630f
Autor:
Andrew Forrest, Luca Giacovazzi, Sarah Dunlop, Julia Reisser, David Tickler, Alan Jamieson, Jessica J. Meeuwig
Publikováno v:
Frontiers in Marine Science, Vol 6 (2019)
Marine plastic pollution is a symptom of an inherently wasteful linear plastic economy, costing us more than US$ 2.2 trillion per year. Of the 6.3 billion tonnes of fossil fuel-derived plastic (FFP) waste produced to date, only 9% has been recycled;
Externí odkaz:
https://doaj.org/article/d9b71b0cd1904c7681bec138b96fdf5d
Autor:
Emma V. Sheehan, Phil Hosegood, Chloe A. Game, Martin J. Attrill, David Tickler, Marianne Wootton, David G. Johns, Jessica J. Meeuwig
Publikováno v:
Frontiers in Marine Science, Vol 6 (2019)
Within atolls, deep water channels exert significant control over local hydrodynamic conditions; which are important drivers of planktonic distributions. To examine planktonic responses to oceanography, this study tested the effect of proximity and e
Externí odkaz:
https://doaj.org/article/ecaf97b17648430e9a20d3becdf46878
Autor:
Aaron B. Carlisle, David Tickler, Jonathan J. Dale, Francesco Ferretti, David J. Curnick, Taylor K. Chapple, Robert J. Schallert, Michael Castleton, Barbara A. Block
Publikováno v:
Frontiers in Marine Science, Vol 6 (2019)
Marine protected areas (MPAs) have become an increasingly important tool to protect and conserve marine resources. However, there remains much debate about how effective MPAs are, especially in terms of their ability to protect mobile marine species
Externí odkaz:
https://doaj.org/article/d2079518a06e4704af386079e66cbe49