Zobrazeno 1 - 10
of 144
pro vyhledávání: '"David Ternant"'
Autor:
Tatjana Welzel, Klervi Golhen, Andrew Atkinson, Verena Gotta, David Ternant, Jasmin B. Kuemmerle-Deschner, Christine Michler, Gilbert Koch, Johannes N. van den Anker, Marc Pfister, Andreas Woerner
Publikováno v:
Pediatric Rheumatology Online Journal, Vol 22, Iss 1, Pp 1-12 (2024)
Abstract Background In pediatric rheumatic diseases (PRD), adalimumab is dosed using fixed weight-based bands irrespective of methotrexate co-treatment, disease activity (DA) or other factors that might influence adalimumab pharmacokinetics (PK). In
Externí odkaz:
https://doaj.org/article/f2c51365bcf44787aa48f649528e7736
Autor:
Julien Lejeune, Violette Raoult, Mathilde Dubrasquet, Romane Chauvin, Coralie Mallebranche, Isabelle Pellier, Françoise Monceaux, Sophie Bayart, Audrey Grain, Emmanuel Gyan, Noémie Ravalet, Olivier Herault, David Ternant
Publikováno v:
HemaSphere, Vol 7, Iss 11, p e960 (2023)
Childhood immune thrombocytopenia (ITP) is a rare autoimmune disorder characterized by isolated thrombocytopenia. Prolonged ITP (persistent and chronic) leads to a reduced quality of life for children in many domains. To provide optimal support for c
Externí odkaz:
https://doaj.org/article/aeebbd662932436194a15bef27c773d2
Autor:
Emmanuel Gyan, Arnaud Pigneux, Mathilde Hunault, Pierre Peterlin, Martin Carré, Jacques-Olivier Bay, Caroline Bonmati, Maria-Pilar Gallego-Hernanz, Bruno Lioure, Philippe Bertrand, Nicolas Vallet, David Ternant, François Darrouzain, Frédéric Picou, Marie-Christine Béné, Christian Récher, Olivier Hérault
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-9 (2022)
Abstract The treatment of acute myeloid leukemia (AML) with unfavorable cytogenetics treatment remains a challenge. We previously established that ex vivo exposure of AML blasts to eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), or fish oil
Externí odkaz:
https://doaj.org/article/c5b28a8dd12a453e8e73b7f9e96cc55b
Autor:
Blaise Pasquiers, Salih Benamara, Mathieu Felices, David Ternant, Xavier Declèves, Alicja Puszkiel
Publikováno v:
Pharmaceutics, Vol 15, Iss 8, p 2129 (2023)
Interspecies translation of monoclonal antibodies (mAbs) pharmacokinetics (PK) in presence of target-mediated drug disposition (TMDD) is particularly challenging. Incorporation of TMDD in physiologically based PK (PBPK) modeling is recent and needs t
Externí odkaz:
https://doaj.org/article/90f98f4a5788487281bfad7713e17aad
Autor:
Cristina Bagacean, Adrian Tempescul, David Ternant, Anne Banet, Nathalie Douet-Guilbert, Anne Bordron, Boutahar Bendaoud, Hussam Saad, Mihnea Zdrenghea, Christian Berthou, Gilles Paintaud, Yves Renaudineau
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 7, Iss 1, Pp 1-5 (2019)
Abstract Chronic lymphocytic leukemia (CLL) is the most common type of leukemia and the anti-CD20 monoclonal antibody, rituximab, represents the therapeutic gold standard for more than 2 decades in this pathology, when used in combination with chemot
Externí odkaz:
https://doaj.org/article/874ce61e568a46c38d593ea120b275c2
Autor:
Grégoire Cormier, Benoit Le Goff, Emmanuelle Dernis, Philippe Goupille, Aleth Perdriger, Theo Rispens, David Ternant, Gilles Paintaud, Emilie Ducourau, Marine Samain, Fabienne Le Guilchard, Lucia Andras, Eric Lespessailles, Thomas Armingeat, Valérie Devauchelle-Pensec, Elisabeth Gervais, Annick de Vries, Eric Piver, Céline Desvignes, Hervé Watier, Denis Mulleman
Publikováno v:
RMD Open, Vol 6, Iss 1 (2020)
Objectives Anti-drug antibodies (ADA) are responsible for decreased adalimumab efficacy in axial spondyloarthritis (SpA). We aimed to evaluate the ability of methotrexate (MTX) to decrease adalimumab immunisation.Methods A total of 110 patients eligi
Externí odkaz:
https://doaj.org/article/34baabbabbb84c789d1f58a0aed02800
Autor:
Fabien Espitalier, François Darrouzain, Jean-Michel Escoffre, David Ternant, Eric Piver, Ayache Bouakaz, Francis Remerand
Publikováno v:
Frontiers in Pharmacology, Vol 10 (2020)
The poor diffusion of intravenous antibiotics in lung tissue makes nosocomial pneumonia challenging to treat, notably in critical patients under mechanical ventilation. The combination of ultrasound and microbubbles (USMB) is an emerging method for n
Externí odkaz:
https://doaj.org/article/e04ab368bd0c49519bde3641b12a16c6
Autor:
David Ternant, Olivier Le Tilly, Laurence Picon, Driffa Moussata, Christophe Passot, Theodora Bejan-Angoulvant, Céline Desvignes, Denis Mulleman, Philippe Goupille, Gilles Paintaud
Publikováno v:
Pharmaceutics, Vol 13, Iss 11, p 1821 (2021)
Infliximab is an anti-TNF-α monoclonal antibody approved in chronic inflammatory bowel diseases (IBD). This study aimed at providing an in-depth description of infliximab target-mediated pharmacokinetics in 133 IBD patients treated with 5 mg/kg infl
Externí odkaz:
https://doaj.org/article/e2d78037197449f6a4091c5a92ae7319
Autor:
Clémence Marin, Nihel Khoudour, Aurélien Millet, Dorothée Lebert, Pauline Bros, Fabienne Thomas, David Ternant, Bruno Lacarelle, Jérôme Guitton, Joseph Ciccolini, Benoit Blanchet
Publikováno v:
Pharmaceuticals, Vol 14, Iss 8, p 796 (2021)
Background: Different liquid chromatography tandem mass spectrometry (LC–MS/MS) methods have been published for quantification of monoclonal antibodies (mAbs) in plasma but thus far none allowed the simultaneous quantification of several mAbs, incl
Externí odkaz:
https://doaj.org/article/77c04e28bb494b1c898c4fa64aa833ae
Autor:
Gilles Thibault, Gilles Paintaud, Hsueh Cheng Sung, Laurie Lajoie, Edouard Louis, the GETAID, Celine Desvignes, Hervé Watier, Valérie Gouilleux-Gruart, David Ternant
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 11, p 6051 (2021)
The FcγRIIA/CD32A is mainly expressed on platelets, myeloid and several endothelial cells. Its affinity is considered insufficient for allowing significant binding of monomeric IgG, while its H131R polymorphism (histidine > arginine at position 131)
Externí odkaz:
https://doaj.org/article/5d2eee466cec46b1844ec186e07ad43c