Zobrazeno 1 - 10
of 76
pro vyhledávání: '"David Tannahill"'
Autor:
Sean M. Flynn, Somdutta Dhir, Krzysztof Herka, Colm Doyle, Larry Melidis, Angela Simeone, Winnie W. I. Hui, Rafael de Cesaris Araujo Tavares, Stefan Schoenfelder, David Tannahill, Shankar Balasubramanian
Publikováno v:
Genome Biology, Vol 25, Iss 1, Pp 1-10 (2024)
Abstract Methods to measure chromatin contacts at genomic regions bound by histone modifications or proteins are important tools to investigate chromatin organization. However, such methods do not capture the possible involvement of other epigenomic
Externí odkaz:
https://doaj.org/article/64f8f18f52c349d5bcf820beb8d79a27
Autor:
Katherine G. Zyner, Angela Simeone, Sean M. Flynn, Colm Doyle, Giovanni Marsico, Santosh Adhikari, Guillem Portella, David Tannahill, Shankar Balasubramanian
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)
Whether G-quadruplexes (G4s) regulate stem cell self-renewal and fate determination during embryonic development is not well understood. Here, the authors reveal that the embryonic stem cell state is defined by very high G4 abundance. G4s are progres
Externí odkaz:
https://doaj.org/article/23f994531a2a400ebdc8f744da78d2b7
Autor:
Winnie W. I. Hui, Angela Simeone, Katherine G. Zyner, David Tannahill, Shankar Balasubramanian
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-7 (2021)
Abstract G-quadruplexes (G4s) are four-stranded DNA secondary structures that form in guanine-rich regions of the genome. G4s have important roles in transcription and replication and have been implicated in genome instability and cancer. Thus far mo
Externí odkaz:
https://doaj.org/article/003e83e1b961406db41ad6a9bc1d03f5
Autor:
Dhaval Varshney, Sergio Martinez Cuesta, Barbara Herdy, Ummi Binti Abdullah, David Tannahill, Shankar Balasubramanian
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
Abstract Four-stranded G-quadruplex (G4) structures form from guanine-rich tracts, but the extent of their formation in cellular RNA and details of their role in RNA biology remain poorly defined. Herein, we first delineate the presence of endogenous
Externí odkaz:
https://doaj.org/article/74c8d5eda01043c79eff0b1eba8756f2
Autor:
Jiazhen Shen, Dhaval Varshney, Angela Simeone, Xiaoyun Zhang, Santosh Adhikari, David Tannahill, Shankar Balasubramanian
Publikováno v:
Genome Biology, Vol 22, Iss 1, Pp 1-14 (2021)
Abstract Background Four-stranded G-quadruplexes (G4s) are DNA secondary structures in the human genome that are primarily found in active promoters associated with elevated transcription. Here, we explore the relationship between the folding of prom
Externí odkaz:
https://doaj.org/article/d4efa02a305743abbb6af4b97685632b
Autor:
Jochen Spiegel, Sergio Martínez Cuesta, Santosh Adhikari, Robert Hänsel-Hertsch, David Tannahill, Shankar Balasubramanian
Publikováno v:
Genome Biology, Vol 22, Iss 1, Pp 1-15 (2021)
Abstract Background The binding of transcription factors (TF) to genomic targets is critical in the regulation of gene expression. Short, double-stranded DNA sequence motifs are routinely implicated in TF recruitment, but many questions remain on how
Externí odkaz:
https://doaj.org/article/9f8b5612a9704b0d81021d616a1426e9
Autor:
Winnie W. I. Hui, Angela Simeone, Katherine G. Zyner, David Tannahill, Shankar Balasubramanian
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-1 (2022)
Externí odkaz:
https://doaj.org/article/fa17c9f7f4af47b3828a52d7935f98ee
Autor:
Katherine G Zyner, Darcie S Mulhearn, Santosh Adhikari, Sergio Martínez Cuesta, Marco Di Antonio, Nicolas Erard, Gregory J Hannon, David Tannahill, Shankar Balasubramanian
Publikováno v:
eLife, Vol 8 (2019)
G-quadruplexes (G4) are alternative nucleic acid structures involved in transcription, translation and replication. Aberrant G4 formation and stabilisation is linked to genome instability and cancer. G4 ligand treatment disrupts key biological proces
Externí odkaz:
https://doaj.org/article/9345f52ec2454d159923cd9ac4bc1bbf
Publikováno v:
PLoS ONE, Vol 9, Iss 7, p e102711 (2014)
Four-stranded G-quadruplex DNA secondary structures have recently been visualized in the nuclei of human cultured cells. Here, we show that BG4, a G-quadruplex-specific antibody, can be used to stain DNA G-quadruplex structures in patient-derived tis
Externí odkaz:
https://doaj.org/article/a46b279b6359453fbc34b8e08ba9891c
Autor:
Neil V Morgan, Mark R Morris, Hakan Cangul, Diane Gleeson, Anna Straatman-Iwanowska, Nicholas Davies, Stephen Keenan, Shanaz Pasha, Fatimah Rahman, Dean Gentle, Maaike P G Vreeswijk, Peter Devilee, Margaret A Knowles, Serdar Ceylaner, Richard C Trembath, Carlos Dalence, Erol Kismet, Vedat Köseoğlu, Hans-Christoph Rossbach, Paul Gissen, David Tannahill, Eamonn R Maher
Publikováno v:
PLoS Genetics, Vol 6, Iss 2, p e1000833 (2010)
The histiocytoses are a heterogeneous group of disorders characterised by an excessive number of histiocytes. In most cases the pathophysiology is unclear and treatment is nonspecific. Faisalabad histiocytosis (FHC) (MIM 602782) has been classed as a
Externí odkaz:
https://doaj.org/article/d36e35d927b4446f86206acd3e9be0ec