Zobrazeno 1 - 10 of 10 pro vyhledávání: '"David T.R. Coulson"'
1
alpha-Synuclein mRNA and soluble alpha-synuclein protein levels in post-mortem brain from patients with Parkinson's disease, dementia with Lewy bodies, and Alzheimer's disease
Autor: Rivka Ravid, Simon Brockbank, David T.R. Coulson, Joseph F. Quinn, Jan Hellemans, Janet A. Johnston, Nancy Beyer, G. Brent Irvine
Publikováno v: Brain Research, 1459, 71-80. Elsevier B.V.
α-Synuclein is a neuronal protein implicated in the etiology of Parkinson's disease (PD) and dementia with Lewy bodies (DLB). Whilst increased α-synuclein expression due to gene duplication or triplication can cause familial PD, previous studies of
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c13561297a3a8d7dab1337b966befcf3
https://doi.org/10.1016/j.brainres.2012.04.018
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2
BACE1 mRNA Expression in Alzheimer's Disease Postmortem Brain Tissue
Autor: David T.R. Coulson, Nancy Beyer, Simon Brockbank, Jan Hellemans, Joseph F. Quinn, Janet A. Johnston, G. Brent Irvine, Rivka Ravid
Publikováno v: Journal of Alzheimer's Disease, 22, 1111-1122. IOS Press
β-site AβPP cleaving enzyme 1 (BACE1) catalyses the rate-limiting step for production of amyloid-β (Aβ) peptides, involved in the pathological cascade underlying Alzheimer's disease (AD). Elevated BACE1 protein levels and activity have been repor
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::188572f42cc9166049726f99c0f43b6a
https://doi.org/10.3233/jad-2010-101254
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3
A novel reciprocal and biphasic relationship between membrane cholesterol and β-secretase activity in SH-SY5Y cells and in human platelets
Autor: A. Peter Passmore, M. McConville, G. Brent Irvine, Stephen Todd, W.W. Liu, David T.R. Coulson, Bernadette McGuinness, Janet A. Johnston, David Craig
Publikováno v: Journal of Neurochemistry. 108:341-349
Research into the cause of Alzheimer's disease (AD) has identified strong connections to cholesterol. Cholesterol and cholesterol esters can modulate amyloid precursor protein (APP) processing, thus altering production of the Abeta peptides that depo
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee48d996d400decafdccd9c779bfeacb
https://doi.org/10.1111/j.1471-4159.2008.05753.x
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4
Elevated Platelet β-Secretase Activity in Mild Cognitive Impairment
Autor: Anthony Peter Passmore, G.B. Irvine, W.W. Liu, Janet A. Johnston, Suzanne P. Murphy, David T.R. Coulson, David Craig, Stephen Todd
Publikováno v: Dementia and Geriatric Cognitive Disorders. 24:464-468
Background/Aims: We have recently reported that platelet activity of the rate-limiting enzyme for β-amyloid peptide production is elevated in established Alzheimer’s disease. Laboratory investigation of the very early stages of dementia provides a
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1021a5affd2dd4ea2f6ddd35fe6ee53a
https://doi.org/10.1159/000110739
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8
Identification of valid reference genes for the normalization of RT qPCR gene expression data in human brain tissue
Autor: Rivka Ravid, Janet A. Johnston, David T.R. Coulson, G. Brent Irvine, Suzanne P. Murphy, Simon Brockbank, Joseph F. Quinn
Publikováno v: BMC Molecular Biology, 9. BioMed Central
BMC Molecular Biology, Vol 9, Iss 1, p 46 (2008)
BMC Molecular Biology
Background Studies of gene expression in post mortem human brain can contribute to understanding of the pathophysiology of neurodegenerative diseases, including Alzheimer's disease (AD), Parkinson's disease (PD) and dementia with Lewy bodies (DLB). Q
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::406d8ec51e48600b055c06d5efd74684
https://pure.knaw.nl/portal/en/publications/4fa3d609-bdfb-438b-a86f-5cc6f18cd81c
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10
Expression and activity of beta-site amyloid precursor protein cleaving enzyme in Alzheimer's disease
Autor: David T.R. Coulson, W.W. Liu, Anthony Peter Passmore, Stephen Todd, G.B. Irvine, Janet A. Johnston, Suzanne P. Murphy
Publikováno v: Biochemical Society transactions. 33(Pt 5)
Several lines of evidence indicate that the Abeta peptide is involved at some level in the pathological process that results in the clinical symptoms of AD (Alzheimer's disease). The N-terminus of Abeta is generated by cleavage of the Met-Asp bond at
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fead67ddb93ca8b78028b8d5b7d618a0
https://pubmed.ncbi.nlm.nih.gov/16246054
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