Zobrazeno 1 - 10
of 32
pro vyhledávání: '"David T. White"'
Autor:
Kevin Emmerich, David T. White, Siva P. Kambhampati, Grace L. Casado, Tian-Ming Fu, Zeeshaan Chunawala, Arpan Sahoo, Saumya Nimmagadda, Nimisha Krishnan, Meera T. Saxena, Steven L. Walker, Eric Betzig, Rangaramanujam M. Kannan, Jeff S. Mumm
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-14 (2023)
Abstract Retinal Müller glia function as injury-induced stem-like cells in zebrafish but not mammals. However, insights gleaned from zebrafish have been applied to stimulate nascent regenerative responses in the mammalian retina. For instance, micro
Externí odkaz:
https://doaj.org/article/0098c0b5f2dd4606b3cf44ca818c8a43
Autor:
Laura Asnaghi, David T. White, Lynn Yoon, Antoinette Price, Grace Y. Lee, Arpan Sahoo, Jeff S. Mumm, Charles G. Eberhart
Publikováno v:
Acta Neuropathologica Communications, Vol 7, Iss 1, Pp 1-9 (2019)
Abstract Retinoblastoma is the most common intraocular malignancy in children. We previously found that the ACVR1C/SMAD2 pathway is significantly upregulated in invasive retinoblastoma samples from patients. Here we studied the role of an ACVR1C liga
Externí odkaz:
https://doaj.org/article/8cff5bcb009d404d8a5efdcde30e776b
Autor:
Arife Unal Eroglu, Timothy S. Mulligan, Liyun Zhang, David T. White, Sumitra Sengupta, Cathy Nie, Noela Y. Lu, Jiang Qian, Lisha Xu, Wuhong Pei, Shawn M. Burgess, Meera T. Saxena, Jeff S. Mumm
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 6 (2018)
Thousands of genes have been implicated in retinal regeneration, but only a few have been shown to impact the regenerative capacity of Müller glia—an adult retinal stem cell with untapped therapeutic potential. Similarly, among nearly 300 genetic
Externí odkaz:
https://doaj.org/article/26f4e85cc8724161b9abfd475abe72c6
Autor:
Fausto J. Rodriguez, Jeff S. Mumm, Eric H. Raabe, Liqun Jiang, Jeffrey Rubens, Ming Yuan, Liam Chen, Jennifer Bynum, Eric M. Jackson, Linda M.S. Resar, Charles G. Eberhart, David T. White, Mari L. Groves, Alan R. Cohen, Eli E. Bar
Publikováno v:
Neuro Oncol
Background The conditional reprogramming cell culture method was developed to facilitate growth of senescence-prone normal and neoplastic epithelial cells, and involves co-culture with irradiated fibroblasts and the addition of a small molecule Rho k
Autor:
Abigail V. Sharrock, Timothy S. Mulligan, Kelsi R. Hall, Elsie M. Williams, David T. White, Liyun Zhang, Kevin Emmerich, Frazer Matthews, Saumya Nimmagadda, Selena Washington, Katherine D. Le, Danielle Meir-Levi, Olivia L. Cox, Meera T. Saxena, Anne L. Calof, Martha E. Lopez-Burks, Arthur D. Lander, Ding Ding, Hongkai Ji, David F. Ackerley, Jeff S. Mumm
Publikováno v:
Nature methods, vol 19, iss 2
Transgenic expression of bacterial nitroreductase (NTR) enzymes sensitizes eukaryotic cells to prodrugs such as metronidazole (MTZ), enabling selective cell-ablation paradigms that have expanded studies of cell function and regeneration in vertebrate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12fc22cea9ed01529cf478d87a37f105
https://escholarship.org/uc/item/1fn995n4
https://escholarship.org/uc/item/1fn995n4
Autor:
Guangliang Wang, Surendra K Rajpurohit, Fabien Delaspre, Steven L Walker, David T White, Alexis Ceasrine, Rejji Kuruvilla, Ruo-jing Li, Joong S Shim, Jun O Liu, Michael J Parsons, Jeff S Mumm
Publikováno v:
eLife, Vol 4 (2015)
Whole-organism chemical screening can circumvent bottlenecks that impede drug discovery. However, in vivo screens have not attained throughput capacities possible with in vitro assays. We therefore developed a method enabling in vivo high-throughput
Externí odkaz:
https://doaj.org/article/6bc5a75f96814fc3aa7ccaecb3f5d1b1
Publikováno v:
Adv Drug Deliv Rev
Several key attributes of zebrafish make them an ideal model system for the discovery and development of regeneration promoting therapeutics; most notably their robust capacity for self-repair which extends to the central nervous system. Further, by
Autor:
Saleh Al-Mesfer, Azza Maktabi, Grace Y. Lee, Charles G. Eberhart, Deepak P. Edward, Laura Asnaghi, Jeff S. Mumm, Christopher G. Hurtado, Nolan Key, Alka Mahale, Sahar M. Elkhamary, Joshua Choi, David T. White, Leen Abu Safieh, Angel M. Carcaboso, Hind M. Alkatan
Publikováno v:
Oncogene
Retinoblastoma is the most common intraocular cancer in children. While the primary tumor can often be treated by local or systemic chemotherapy, metastatic dissemination is generally resistant to therapy and remains a leading cause of pediatric canc
Autor:
Jeff S. Mumm, Rangaramanujam M. Kannan, Eric Betzig, Tian-Ming Fu, David T. White, Arpan Sahoo, Grace Y. Lee, Kevin Emmerich, Meera T. Saxena, Siva P. Kambhamptati
Müller glia (MG) function as injury-induced retinal stem cells in zebrafish but not mammals. Insights from zebrafish, however, have been used to stimulate limited regenerative responses from mammalian MG. Microglia/macrophages regulate MG stem cell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6e91d32c9473d726d800e3f54f4c1965
https://doi.org/10.1101/2020.08.05.238352
https://doi.org/10.1101/2020.08.05.238352
Autor:
Kevin B. Emmerich, Steven L. Walker, Guohua Wang, David T. White, Fang Wang, Yong Teng, Anneliese Ceisel, Zeeshaan Chunawala, Gianna Graziano, Saumya Nimmagadda, Meera T. Saxena, Jiang Qian, Jeff S. Mumm
Retinal Müller glia (MG) can act as stem-like cells to generate new neurons in both zebrafish in mice. In zebrafish, retinal regeneration is innate and robust, resulting in the replacement of lost neurons and restoration of visual function. In mice,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0fd9ddbbcd6c4976bef764af2591d8fe
https://doi.org/10.1101/2020.08.04.236299
https://doi.org/10.1101/2020.08.04.236299