Zobrazeno 1 - 10
of 40
pro vyhledávání: '"David T. Stanton"'
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry. 30:1-8
Inhibitors of the sarco/endoplasmic reticulum calcium ATPase (SERCA) are valuable research tools and hold promise as a new generation of anti-prostate cancer agents. Based on previously determined potencies of phenolic SERCA inhibitors, we created qu
Autor:
David T. Stanton
Publikováno v:
Current Computer Aided-Drug Design. 8:107-127
Carefully developed quantitative structure-activity and structure-property relationship models contain detailed information regarding how differences in the molecular structure of compounds correlate with differences in the observed biological or oth
Autor:
David T. Stanton, Jodie Zultowsky, Michael Lape, Joel R. Deye, Christopher Elam, Stefan Paula
Publikováno v:
European Journal of Medicinal Chemistry. 46:1512-1523
Two screening protocols based on recursive partitioning and computational ligand docking methodologies, respectively, were employed for virtual screens of a compound library with 345,000 entries for novel inhibitors of the enzyme sarco/endoplasmic re
Publikováno v:
Analytical Chemistry. 78:7467-7472
The search for greater speed of analysis has fueled many innovations in high-performance liquid chromatography (HPLC), such as the use of higher pressures and smaller stationary-phase particles, and the development of monolithic columns. Alternativel
Autor:
David T. Stanton, Manuel Zarzo
Publikováno v:
Chemical Senses. 31:713-724
Many classifications of odors have been proposed, but none of them have yet gained wide acceptance. Odor sensation is usually described by means of odor character descriptors. If these semantic profiles are obtained for a large diversity of compounds
Autor:
Romualdo Benigni, Tatiana I. Netzeva, Gilman Veith, Terry W Schultz, Roger Perkins, Gilles Klopman, Johannes J.M. van de Sandt, Nina Nikolova-Jeliazkova, Andrew Worth, Joanna Jaworska, David W. Roberts, Mark T. D. Cronin, Glenn J. Myatt, Carol A. Marchant, Chihae Yang, Weida Tong, Paola Gramatica, Tom Aldenberg, Scott Kahn, Grace Patlewicz, David T. Stanton
Publikováno v:
Alternatives to Laboratory Animals. 33:155-173
This is the 52nd report of a series of workshops organised by the European Centre for the Validation of Alternative Methods (ECVAM). The main objective of ECVAM, as defined in 1993 by its Scientific Advisory Committee, is to promote the scientific an
Publikováno v:
Journal of Separation Science. 27:115-123
Supercritical fluid chromatography has primarily been applied to relatively nonpolar analytes, even when polar organic solvents are used as modifiers. Here, we show that low levels of volatile ammonium salts as mobile-phase additives allow the elutio
Autor:
David T. Stanton
Publikováno v:
Journal of Chemical Information and Computer Sciences. 43:1423-1433
Multidimensional quantitative structure-activity models (QSAR) developed using molecular structure descriptors and regression analysis techniques have found wide utility and acceptance. However, it is often difficult to extract a physical interpretat
Autor:
Sandra L. Nelson, Thomas M Burt, Lisa E Williams, Barbara R Kuzmak, David T. Stanton, Kenneth L. Morand, Barbara A. Kozikowski, Debra A Tirey
Publikováno v:
SLAS Discovery. 8:205-209
The stability of approximately 7200 compounds stored as 20-mM DMSO solutions under ambient conditions was monitored for 1 year. Compound integrity was measured by flow injection analysis using positive and negative electrospray ionization mass spectr
Publikováno v:
Drug Development and Industrial Pharmacy. 28:193-202
The increasing size of chemical libraries being analyzed by high-throughput screening results in a growing number of active compounds that need to be assessed before moving forward in the drug development process. As a consequence, more rapid and hig