Zobrazeno 1 - 10
of 43
pro vyhledávání: '"David T. Riglar"'
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 10 (2022)
The mammalian gut and its microbiome form a temporally dynamic and spatially heterogeneous environment. The inaccessibility of the gut and the spatially restricted nature of many gut diseases translate into difficulties in diagnosis and therapy for w
Externí odkaz:
https://doaj.org/article/da935e3d0b2545c7a747d7d1351ef890
Autor:
David T. Riglar, David L. Richmond, Laurent Potvin-Trottier, Andrew A. Verdegaal, Alexander D. Naydich, Somenath Bakshi, Emanuele Leoncini, Lorena G. Lyon, Johan Paulsson, Pamela A. Silver
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
Synthetic gene oscillators can be used to control timed function and periodic expression of genes. Here the authors demonstrate in vivo implementation in the mammalian gut that can keep time over several days.
Externí odkaz:
https://doaj.org/article/318e46930f814075b90ecd9d069da686
Autor:
David T. Riglar, David L. Richmond, Laurent Potvin-Trottier, Andrew A. Verdegaal, Alexander D. Naydich, Somenath Bakshi, Emanuele Leoncini, Lorena G. Lyon, Johan Paulsson, Pamela A. Silver
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-2 (2021)
A Correction to this paper has been published: https://doi.org/10.1038/s41467-021-22149-5
Externí odkaz:
https://doaj.org/article/5c4bb1152cb246d793f9a8248a094d2e
Autor:
Alexander D. Naydich, Shannon N. Nangle, Johannes J. Bues, Disha Trivedi, Nabeel Nissar, Mara C. Inniss, Matthew J. Niederhuber, Jeffrey C. Way, Pamela A. Silver, David T. Riglar
Publikováno v:
mSystems, Vol 4, Iss 4 (2019)
ABSTRACT Engineering synthetic circuits into intestinal bacteria to sense, record, and respond to in vivo signals is a promising new approach for the diagnosis, treatment, and prevention of disease. However, because the design of disease-responsive c
Externí odkaz:
https://doaj.org/article/a670a59b6f6541ef8395330c64f5fd82
Autor:
Marika Ziesack, Travis Gibson, John K. W. Oliver, Andrew M. Shumaker, Bryan B. Hsu, David T. Riglar, Tobias W. Giessen, Nicholas V. DiBenedetto, Lynn Bry, Jeffrey C. Way, Pamela A. Silver, Georg K. Gerber
Publikováno v:
mSystems, Vol 4, Iss 4 (2019)
ABSTRACT In nature, microbes interact antagonistically, neutrally, or beneficially. To shed light on the effects of positive interactions in microbial consortia, we introduced metabolic dependencies and metabolite overproduction into four bacterial s
Externí odkaz:
https://doaj.org/article/d11d2e80b5fb41c3b5f8c22f1ff4e2ba
Autor:
Kailash Ramlaul, Ziyi Feng, Caoimhe Canavan, Natàlia de Martín Garrido, David Carreño, Michael Crone, Kirsten E. Jensen, Bing Li, Harry Barnet, David T. Riglar, David Miller, Paul S. Freemont, Christopher H. S. Aylett
While recent advances in cryogenic electron microscopy coupled with single particle analysis have the potential to allow structure determination in a near-native state from vanishingly few individual particles, this vision has yet to be realised in p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::39b6c63ab850304edad0ace0fc9b8011
https://doi.org/10.1101/2023.03.17.533159
https://doi.org/10.1101/2023.03.17.533159
Autor:
Hayley E. Bullen, Paul R. Sanders, Madeline G. Dans, Thorey K. Jonsdottir, David T. Riglar, Oliver Looker, Catherine S. Palmer, Betty Kouskousis, Sarah C. Charnaud, Tony Triglia, Mikha Gabriela, Molly Parkyn Schneider, Jo‐Anne Chan, Tania F. de Koning‐Ward, Jake Baum, James W. Kazura, James G. Beeson, Alan F. Cowman, Paul R. Gilson, Brendan S. Crabb
Publikováno v:
Molecular Microbiology. 117:1245-1262
Infection with Plasmodium falciparum parasites results in approximately 627,000 deaths from malaria annually. Key to the parasite's success is their ability to invade and subsequently grow within human erythrocytes. Parasite proteins involved in para
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59e333ce452776bb3cf5ddf9a8f4b7c1
https://doi.org/10.1111/mmi.14904
https://doi.org/10.1111/mmi.14904
Autor:
Pamela A. Silver, Johan Paulsson, Emanuele Leoncini, David T. Riglar, Andrew A Verdegaal, Laurent Potvin-Trottier, Alexander Naydich, Somenath Bakshi, David L. Richmond, Lorena Lyon
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-2 (2021)
A Correction to this paper has been published: https://doi.org/10.1038/s41467-021-22149-5
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0fdeb99a8b8c7df7b60e6181291265b0
https://doi.org/10.1038/s41467-021-22149-5
https://doi.org/10.1038/s41467-021-22149-5
Autor:
Lorena Lyon, Emanuele Leoncini, David T. Riglar, Pamela A. Silver, Alexander Naydich, David L. Richmond, Johan Paulsson, Andrew A Verdegaal, Somenath Bakshi, Laurent Potvin-Trottier
Publikováno v:
Nature Communications
Nature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
Nature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
Funder: Harvard Medical School; doi: https://doi.org/10.13039/100006691
Funder: Wyss Institute for Biologically Inspired Engineering
Synthetic gene oscillators have the potential to control timed functions and periodic gene expression in en
Funder: Wyss Institute for Biologically Inspired Engineering
Synthetic gene oscillators have the potential to control timed functions and periodic gene expression in en
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::651f4da9df7fe74d0a46da29df17794d
Autor:
Pamela A. Silver, David T. Riglar
Publikováno v:
Nature Reviews Microbiology. 16:214-225
Our ability to generate bacterial strains with unique and increasingly complex functions has rapidly expanded in recent times. The capacity for DNA synthesis is increasing and costing less; new tools are being developed for fast, large-scale genetic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05cdf5bf3da841fbc3bf7740ab02efdb
https://doi.org/10.1038/nrmicro.2017.172
https://doi.org/10.1038/nrmicro.2017.172