Zobrazeno 1 - 10
of 886
pro vyhledávání: '"David T. Curiel"'
Autor:
Chandramani Singh, Savita Verma, Prabhakar Reddy, Michael S. Diamond, David T. Curiel, Chintan Patel, Manish Kumar Jain, Sagar Vivek Redkar, Amit Suresh Bhate, Vivek Gundappa, Rambabu Konatham, Leelabati Toppo, Aniket Chandrakant Joshi, Jitendra Singh Kushwaha, Ajit Pratap Singh, Shilpa Bawankule, Raches Ella, Sai Prasad, Brunda Ganneru, Siddharth Reddy Chiteti, Sreenivas Kataram, Krishna Mohan Vadrevu
Publikováno v:
npj Vaccines, Vol 8, Iss 1, Pp 1-9 (2023)
Abstract One of the most preferable characteristics for a COVID-19 vaccine candidate is the ability to reduce transmission and infection of SARS-CoV-2, in addition to disease prevention. Unlike intramuscular vaccines, intranasal COVID-19 vaccines may
Externí odkaz:
https://doaj.org/article/942566a9fd284c139cb86bb0528dbc2a
Autor:
Kexin Geng, Paul J. Rice-Boucher, Elena A. Kashentseva, Igor P. Dmitriev, Zhi Hong Lu, S. Peter Goedegebuure, William E. Gillanders, David T. Curiel
Publikováno v:
Viruses, Vol 15, Iss 11, p 2277 (2023)
mRNA vaccines have attracted widespread research attention with clear advantages in terms of molecular flexibility, rapid development, and potential for personalization. However, current mRNA vaccine platforms have not been optimized for induction of
Externí odkaz:
https://doaj.org/article/f5cd8059bf8f48c1a2dd7fc84922e25f
Autor:
Reka Lorincz, Aluet Borrego Alvarez, Christopher J. Walkey, Samir A. Mendonça, Zhi Hong Lu, Alexa E. Martinez, Cecilia Ljungberg, Jason D. Heaney, William R. Lagor, David T. Curiel
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 158, Iss , Pp 114189- (2023)
Biological applications deriving from the clustered regularly interspaced short palindromic repeats (CRISPR)-Cas9 site-specific nuclease system continue to impact and accelerate gene therapy strategies. Safe and effective in vivo co-delivery of the C
Externí odkaz:
https://doaj.org/article/f5ae3e7584154702b3dd6f4928ce5c2c
Autor:
Ana Alfano, Eduardo G. A. Cafferata, Mariela Gangemi, Alejandro Nicola Candia, Cristian M. Malnero, Ismael Bermudez, Mauricio Vargas Lopez, Gregorio David Ríos, Cecilia Rotondaro, Nicasio Cuneo, David T. Curiel, Osvaldo L. Podhajcer, Maria Veronica Lopez
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 12, p 9992 (2023)
More than one million women are diagnosed annually worldwide with a gynecological cancer. Most gynecological cancers are diagnosed at a late stage, either because a lack of symptoms, such as in ovarian cancer or limited accessibility to primary preve
Externí odkaz:
https://doaj.org/article/b808aa64d67841c38238669d4097148b
Publikováno v:
npj Vaccines, Vol 6, Iss 1, Pp 1-14 (2021)
Abstract Adenoviral vectors have been explored as vaccine agents for a range of infectious diseases, and their ability to induce a potent and balanced immune response made them logical candidates to apply to the COVID-19 pandemic. The unique molecula
Externí odkaz:
https://doaj.org/article/2884d62b3ff9428ba246fbb13c87a66c
Autor:
Myungeun Lee, Paul J. Rice-Boucher, Logan Thrasher Collins, Ernst Wagner, Lorenzo Aulisa, Jeffrey Hughes, David T. Curiel
Publikováno v:
Viruses, Vol 14, Iss 10, p 2169 (2022)
Molecular therapies exploiting mRNA vectors embody enormous potential, as evidenced by the utility of this technology for the context of the COVID-19 pandemic. Nonetheless, broad implementation of these promising strategies has been restricted by the
Externí odkaz:
https://doaj.org/article/10047deae23a454ab209be6c271d1f07
Autor:
Ahmed O. Hassan, Swathi Shrihari, Matthew J. Gorman, Baoling Ying, Dansu Yaun, Saravanan Raju, Rita E. Chen, Igor P. Dmitriev, Elena Kashentseva, Lucas J. Adams, Colin Mann, Meredith E. Davis-Gardner, Mehul S. Suthar, Pei-Yong Shi, Erica Ollmann Saphire, Daved H. Fremont, David T. Curiel, Galit Alter, Michael S. Diamond
Publikováno v:
Cell Reports, Vol 36, Iss 4, Pp 109452- (2021)
Summary: SARS-CoV-2 variants that attenuate antibody neutralization could jeopardize vaccine efficacy. We recently reported the protective activity of an intranasally administered spike protein-based chimpanzee adenovirus-vectored vaccine (ChAd-SARS-
Externí odkaz:
https://doaj.org/article/6b5e421c8ddd48718952e62139e47b88
Autor:
Ahmed O. Hassan, Friederike Feldmann, Haiyan Zhao, David T. Curiel, Atsushi Okumura, Tsing-Lee Tang-Huau, James Brett Case, Kimberly Meade-White, Julie Callison, Rita E. Chen, Jamie Lovaglio, Patrick W. Hanley, Dana P. Scott, Daved H. Fremont, Heinz Feldmann, Michael S. Diamond
Publikováno v:
Cell Reports Medicine, Vol 2, Iss 4, Pp 100230- (2021)
Summary: The deployment of a vaccine that limits transmission and disease likely will be required to end the coronavirus disease 2019 (COVID-19) pandemic. We recently described the protective activity of an intranasally administered chimpanzee adenov
Externí odkaz:
https://doaj.org/article/80b40b01f714480999494aa418767c57
Autor:
Rachael Mooney, Asma Abdul Majid, Jennifer Batalla-Covello, Diana Machado, Xueli Liu, Joanna Gonzaga, Revathiswari Tirughana, Mohamed Hammad, Maciej S. Lesniak, David T. Curiel, Karen S. Aboody
Publikováno v:
Molecular Therapy: Oncolytics, Vol 12, Iss , Pp 79-92 (2019)
Oncolytic virotherapy is a promising approach for treating recurrent and/or drug-resistant ovarian cancer. However, its successful application in the clinic has been hampered by rapid immune-mediated clearance or neutralization of the virus, which re
Externí odkaz:
https://doaj.org/article/640fdbac5c2342d1857ec93f5bfc628b
Autor:
Rebeca González-Pastor, Ahmad Mohammad Ashshi, Adel Galal El-Shemi, Igor P. Dmitriev, Elena A. Kashentseva, Zhi Hong Lu, S. Peter Goedegebuure, Osvaldo L. Podhajcer, David T. Curiel
Publikováno v:
Journal of Ovarian Research, Vol 12, Iss 1, Pp 1-10 (2019)
Abstract Background Virotherapy represents a promising approach for ovarian cancer. In this regard, conditionally replicative adenovirus (CRAd) has been translated to the context of human clinical trials. Advanced design of CRAds has sought to exploi
Externí odkaz:
https://doaj.org/article/7c2b01e7eb2848b08117b81f96e23ec9