Zobrazeno 1 - 10
of 94
pro vyhledávání: '"David T. Connor"'
Autor:
Jay R. Luly, Kenneth G. Carson, David J Heilig, Wen Song Yue, Shixin Qin, Jie Jack Li, David T. Connor, Joseph Edwin Low, Roberta A Glynn, Bharat K. Trivedi, Qing Ye, Stephen W. Hunt, Steven R. Miller, Bruce D. Roth, Weixing Yang
Publikováno v:
Bioorganic & Medicinal Chemistry. 11:3777-3790
Interleukin-8 modulation is implicated in many inflammatory and cancer diseases. Starting from a mass-screening hit, the synthesis and structure-activity relationship of 2-amino-3-heteroarylquinoxalines as non-peptide, small molecule interleukine-8 r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67e74b9b8847daee0af115d942196a4b
https://doi.org/10.1016/s0968-0896(03)00399-7
https://doi.org/10.1016/s0968-0896(03)00399-7
Addition reactions of allyl stannanes to an indolo[2′,3′:3,4]pyrido[1,2-b]isoquinoline imminium salt
Autor:
David T. Connor, Bruce D. Roth, Paul C. Unangst, Larry D. Bratton, Bharat K. Trivedi, J. Ronald Rubin
Publikováno v:
Journal of Heterocyclic Chemistry. 37:1081-1087
The addition of organometallic reagents to the 13b-position of the indolo[2′,3′:3,4]pyrido[1,2-b]isoquinoline imminium salt 4 is described. Reaction of 4 with tetraallyl tin in 2-methoxyethanol gave the allyl adduct 7 in moderate yield. Further e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d624ab154a75542cfed7502e15242cab
https://doi.org/10.1002/jhet.5570370510
https://doi.org/10.1002/jhet.5570370510
Autor:
David T. Connor, Robert Doubleday, Lawrence D. Wise, Robert G. MacKenzie, Thomas Capiris, Thomas G. Heffner, Steven Robert Miller, Thomas A. Pugsley, Paul C. Unangst
Publikováno v:
Journal of Medicinal Chemistry. 40:4026-4029
The discovery of a series of novel (aryloxy)alkylamines with selective affinity for the dopamine D4 receptor is described. Target compounds were tested for binding to cloned human dopamine D2, D3, and D4 receptor subtypes expressed in Chinese hamster
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a58a8a70268dfe3365f29e9f5a83a4d
https://doi.org/10.1021/jm970422s
https://doi.org/10.1021/jm970422s
Autor:
Steven Robert Miller, David T. Connor, Lawrence D. Wise, Robert G. MacKenzie, Thomas G. Heffner, and Thomas A. Pugsley, Thomas Capiris, Paul C. Unangst
Publikováno v:
Journal of Medicinal Chemistry. 40:2688-2693
The discovery of a series of chromeno[3,4-c]pyridin-5-ones with selective affinity for the dopamine D4 receptor is described. Target compounds were tested for binding to cloned human dopamine D2, D3, and D4 receptor subtypes expressed in Chinese hams
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b95a99c1a2a18124a0b2b93804ca6180
https://doi.org/10.1021/jm970170v
https://doi.org/10.1021/jm970170v
Autor:
Richard D. Dyer, David T. Connor
Publikováno v:
Current Pharmaceutical Design. 3:463-472
One of the most promising approaches for minimizing the side effects of nonsteroidal antiinflammatory drugs (NSAIDs) is to concurrently inhibit the activities of both 5-lipoxygenase (5-LO) and cyclooxygenase (CO). Many such dual inhibitors of prostag
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ea0a9ff85f123419162c71d67dd59038
https://doi.org/10.2174/138161280305221010095741
https://doi.org/10.2174/138161280305221010095741
Publikováno v:
Journal of Heterocyclic Chemistry. 33:2025-2030
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8bcc34bf02fda9707816b0931ceceaeb
https://doi.org/10.1002/jhet.5570330674
https://doi.org/10.1002/jhet.5570330674
Publikováno v:
Journal of Heterocyclic Chemistry. 33:1627-1630
The preparation of several novel 5-hydroxyindole-2-carboxamides is described. A 5-benzyloxyindole ester was elaborated to the 3-bromo, 3-hydroxy, and 3-alkoxy ester intermediates followed by conversion to the amide and debenzylation. A related 5-acet
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1da4be75218cf4c8f670d67e3506d71b
https://doi.org/10.1002/jhet.5570330614
https://doi.org/10.1002/jhet.5570330614
Publikováno v:
Bioorganic & Medicinal Chemistry. 4:557-562
The surface levels of ICAM-1 and E-selectin on activated endothelial cells can be reduced by 3-alkoxybenzo[b]thiophene-2-carboxamides. This property is shared by several N-alkylthiopyridine substituted imides. Combining structural elements of these t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9fb67558ca271bd4f7951af72c686d56
https://doi.org/10.1016/0968-0896(96)00046-6
https://doi.org/10.1016/0968-0896(96)00046-6
Autor:
C. R. Kostlan, Steven Robert Miller, G. D. Kanter, David T. Connor, Gary P. Shrum, Paul C. Unangst
Publikováno v:
Journal of Heterocyclic Chemistry. 32:1197-1200
The preparation of pyrimidine analogs of the 2,6-di-tert-butylphenol antiinflammatory agents Prifelone (R-830), Tebufelone (NE-11740) and Ym-13,162 is described. Grignard addition to the N-methoxy-N-methylamide derived from 4,6-bis(1,1-dimethylethyl)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e9eb5e180ff201d964e725ec8802a522
https://doi.org/10.1002/jhet.5570320417
https://doi.org/10.1002/jhet.5570320417