Zobrazeno 1 - 10
of 78
pro vyhledávání: '"David T. Clarke"'
Autor:
R. Sumanth Iyer, Sarah R. Needham, Ioannis Galdadas, Benjamin M. Davis, Selene K. Roberts, Rico C. H. Man, Laura C. Zanetti-Domingues, David T. Clarke, Gilbert O. Fruhwirth, Peter J. Parker, Daniel J. Rolfe, Francesco L. Gervasio, Marisa L. Martin-Fernandez
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-21 (2024)
Abstract The Epidermal Growth Factor Receptor (EGFR) is frequently found to be mutated in non-small cell lung cancer. Oncogenic EGFR has been successfully targeted by tyrosine kinase inhibitors, but acquired drug resistance eventually overcomes the e
Externí odkaz:
https://doaj.org/article/85aaaaecf9114b44adb21e316e7276e8
The architecture of EGFR’s basal complexes reveals autoinhibition mechanisms in dimers and oligomers
Autor:
Laura C. Zanetti-Domingues, Dimitrios Korovesis, Sarah R. Needham, Christopher J. Tynan, Shiori Sagawa, Selene K. Roberts, Antonija Kuzmanic, Elena Ortiz-Zapater, Purvi Jain, Rob C. Roovers, Alireza Lajevardipour, Paul M. P. van Bergen en Henegouwen, George Santis, Andrew H. A. Clayton, David T. Clarke, Francesco L. Gervasio, Yibing Shan, David E. Shaw, Daniel J. Rolfe, Peter J. Parker, Marisa L. Martin-Fernandez
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-17 (2018)
To prevent ligand-independent dimerisation the epidermal growth factor receptor (EGFR) is autoinhibited by an extracellular dimer interaction. Here, the authors use several imaging technologies and simulations to provide structural insights on the in
Externí odkaz:
https://doaj.org/article/d8f1227aa2394ee08a80e9812006d6b2
Autor:
Sarah R. Needham, Selene K. Roberts, Anton Arkhipov, Venkatesh P. Mysore, Christopher J. Tynan, Laura C. Zanetti-Domingues, Eric T. Kim, Valeria Losasso, Dimitrios Korovesis, Michael Hirsch, Daniel J. Rolfe, David T. Clarke, Martyn D. Winn, Alireza Lajevardipour, Andrew H. A. Clayton, Linda J. Pike, Michela Perani, Peter J. Parker, Yibing Shan, David E. Shaw, Marisa L. Martin-Fernandez
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-14 (2016)
Epidermal growth factor receptors have been shown to oligomerise upon binding to their cognate ligands. Here, the authors use biochemical, biophysical and cell biology techniques to analyse the structures of these oligomers, and argue that these form
Externí odkaz:
https://doaj.org/article/4106f1db16d64a39ab5d782e227f6e6e
Autor:
Marisa L. Martin-Fernandez, David T. Clarke, Selene K. Roberts, Laura C. Zanetti-Domingues, Francesco L. Gervasio
Publikováno v:
Cells, Vol 8, Iss 4, p 316 (2019)
The epidermal growth factor receptor (EGFR) is historically the prototypical receptor tyrosine kinase, being the first cloned and the first where the importance of ligand-induced dimer activation was ascertained. However, many years of structure dete
Externí odkaz:
https://doaj.org/article/427869c719624fc1b26891cb08331485
Publikováno v:
Methods and Protocols, Vol 2, Iss 1, p 12 (2019)
Single-particle tracking (SPT) has been used and developed over the last 25 years as a method to investigate molecular dynamics, structure, interactions, and function in the cellular context. SPT is able to show how fast and how far individual molecu
Externí odkaz:
https://doaj.org/article/43252622c28b44368659ae4886b7b1c6
Publikováno v:
International Journal of Molecular Sciences, Vol 13, Iss 11, Pp 14742-14765 (2012)
Insights from single-molecule tracking in mammalian cells have the potential to greatly contribute to our understanding of the dynamic behavior of many protein families and networks which are key therapeutic targets of the pharmaceutical industry. Th
Externí odkaz:
https://doaj.org/article/5a4b72e1c2254dce8d2f4df5098c192c
Autor:
Daniel J. Rolfe, Sarah R. Needham, Marisa L. Martin-Fernandez, Laura C. Zanetti-Domingues, Amy N. Moores, Benji C. Bateman, Lin Wang, David T. Clarke
Publikováno v:
Bio Protoc
Our mechanistic understanding of cell function depends on imaging biological processes in cells with molecular resolution. Super-resolution fluorescence microscopy plays a crucial role by reporting cellular ultrastructure with 20-30 nm resolution. Ho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78eac1d987ca31270862937f29a65703
https://europepmc.org/articles/PMC7920322/
https://europepmc.org/articles/PMC7920322/
Autor:
Francesco Luigi Gervasio, Laura C. Zanetti-Domingues, Selene K. Roberts, David T. Clarke, Marisa L. Martin-Fernandez
Publikováno v:
Cells
Cells, Vol 8, Iss 4, p 316 (2019)
Cells, Vol 8, Iss 4, p 316 (2019)
The epidermal growth factor receptor (EGFR) is historically the prototypical receptor tyrosine kinase, being the first cloned and the first where the importance of ligand-induced dimer activation was ascertained. However, many years of structure dete
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45b97614dbe4677a8bceb5e79131f725
http://europepmc.org/articles/PMC6523254
http://europepmc.org/articles/PMC6523254
Autor:
Daniel J. Rolfe, Marisa L. Martin-Fernandez, Sarah R. Needham, Konstantinos Beis, Michele C. Darrow, Maria Romano, Laura C. Zanetti-Domingues, Benji C. Bateman, Sam Astbury, C. Spindloe, Amy N. Moores, Lin Wang, David T. Clarke
Publikováno v:
Communications Biology
Communications Biology, Vol 2, Iss 1, Pp 1-11 (2019)
Communications Biology, Vol 2, Iss 1, Pp 1-11 (2019)
Super-resolution fluorescence microscopy plays a crucial role in our understanding of cell structure and function by reporting cellular ultrastructure with 20–30 nm resolution. However, this resolution is insufficient to image macro-molecular machi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e8a68f7e5b248f73b83c77a7240b62a
http://hdl.handle.net/10044/1/67894
http://hdl.handle.net/10044/1/67894