Zobrazeno 1 - 10
of 15
pro vyhledávání: '"David T Omstead"'
Autor:
Matthew Zhou, William Mallet, Romas Kudirka, Han K Kim, Justin Monnier, Chi-Ling Fu, Jennifer E Melrose, Hung Dao, Paul D Ponath, Katelynn A McEachin, David T Omstead, Cindy Kreder, Stefan Chun, Ying Yueh Lee, Rachel Grgich, Tracey J Lin, Joshua A Walker, Karla A Henning, Shelley E Ackerman, Diane Carrera, Steven J Chapin, Dowdy Jackson, Changshou Gao, Michael N Alonso
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss Suppl 2 (2023)
Externí odkaz:
https://doaj.org/article/30e7900b97ae4dd8a324a8032d05c871
Autor:
David T. Omstead, Franklin Mejia, Jenna Sjoerdsma, Baksun Kim, Jaeho Shin, Sabrina Khan, Junmin Wu, Tanyel Kiziltepe, Laurie E. Littlepage, Basar Bilgicer
Publikováno v:
Journal of Hematology & Oncology, Vol 13, Iss 1, Pp 1-15 (2020)
Abstract Background Drug-loaded nanoparticles have established their benefits in the fight against multiple myeloma; however, ligand-targeted nanomedicine has yet to successfully translate to the clinic due to insufficient efficacies reported in prec
Externí odkaz:
https://doaj.org/article/ad4d2b2124e742b7b7e8ff4e11604ab6
Publikováno v:
Nanoscale. 14:1226-1240
Endosomal escape of nanoparticles (NPs) is a weighty consideration for engineering successful nanomedicines. Although it is well-established that incorporation of histidine (His) in particle design improves endosomal escape for NPs, our understanding
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e40bbe437a402384d97b4ac83a0efb36
https://doi.org/10.1039/d1nr05357d
https://doi.org/10.1039/d1nr05357d
Autor:
Yongyao Fu, Abigail Pajulas, Jocelyn Wang, Baohua Zhou, Anthony Cannon, Cherry Cheuk Lam Cheung, Jilu Zhang, Huaxin Zhou, Amanda Jo Fisher, David T. Omstead, Sabrina Khan, Lei Han, Jean-Christophe Renauld, Sophie Paczesny, Hongyu Gao, Yunlong Liu, Lei Yang, Robert M. Tighe, Paula Licona-Limón, Richard A. Flavell, Shogo Takatsuka, Daisuke Kitamura, Jie Sun, Basar Bilgicer, Catherine R. Sears, Kai Yang, Mark H. Kaplan
Publikováno v:
Nature Communications. 13
Although IL-9 has potent anti-tumor activity in adoptive cell transfer therapy, some models suggest that it can promote tumor growth. Here, we show that IL-9 signaling is associated with poor outcomes in patients with various forms of lung cancer, an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a55d010784dd113165163d1246e454af
https://doi.org/10.1038/s41467-022-31596-7
https://doi.org/10.1038/s41467-022-31596-7
Autor:
Justin A. Kenkel, Fang Xiao, Po Y. Ho, Jess L. Nolin, Rishali K. Gadkari, Laughing Bear Torrez, David T. Omstead, Katelynn A. McEachin, Jason Ptacek, Rachel Grgich, Cecelia I. Pearson, Stefan Chun, Cindy L. Kreder, Karla A. Henning, Han K. Kim, Lu Xu, Steven J. Chapin, Michael N. Alonso, Shelley E. Ackerman
Publikováno v:
Cancer Research. 83:2964-2964
Tumor-associated macrophages (TAMs) are the largest immune cell population in many cancers and play a key role in establishing the immunosuppressive tumor microenvironment (TME) that enables tumor progression. However, TAMs are phenotypically plastic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b5aeb383fd1922289f6d50589d9598bd
https://doi.org/10.1158/1538-7445.am2023-2964
https://doi.org/10.1158/1538-7445.am2023-2964
Autor:
Jenna Sjoerdsma, Basar Bilgicer, Jaeho Shin, Laurie E. Littlepage, Sabrina Khan, Franklin Mejia, Junmin Wu, Tanyel Kiziltepe, David T. Omstead, Baksun Kim
Publikováno v:
Journal of Hematology & Oncology, Vol 13, Iss 1, Pp 1-15 (2020)
Journal of Hematology & Oncology
Journal of Hematology & Oncology
Background Drug-loaded nanoparticles have established their benefits in the fight against multiple myeloma; however, ligand-targeted nanomedicine has yet to successfully translate to the clinic due to insufficient efficacies reported in preclinical s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68cc3756d8b20cfdae1396f7c2a6f39b
http://link.springer.com/article/10.1186/s13045-020-00965-4
http://link.springer.com/article/10.1186/s13045-020-00965-4
Autor:
Sabrina Khan, Franklin Mejia, Jaeho Shin, Gyoyeon Hwang, David T. Omstead, Junmin Wu, Sara L. Cole, Laurie E. Littlepage, Basar Bilgicer
Publikováno v:
Biomaterials. 292:121913
Here, we report a CD138 receptor targeting liposomal formulation (TNP[Prodrug-4]) that achieved efficacious tumor growth inhibition in treating multiple myeloma by overcoming the dose limiting severe toxicity issues of a highly potent drug, Mertansin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6637ef8ce7adeba8ddb6dac9715692ec
https://doi.org/10.1016/j.biomaterials.2022.121913
https://doi.org/10.1016/j.biomaterials.2022.121913
Autor:
Tanyel Kiziltepe, Jonathan D. Ashley, Jared F. Stefanick, Nur Mustafaoglu, Peter E. Deak, David T. Omstead, Basar Bilgicer
Publikováno v:
Journal of Controlled Release. :190-200
Despite ligand-targeted liposomes long garnering interest as drug delivery vehicles for cancer therapeutics, inconsistency in successful outcomes have hindered their translation into the clinic. This is in part due to discrepancies between in vitro d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6309bdd5e6de647a2485903c0fd1cf8f
https://doi.org/10.1016/j.jconrel.2019.08.033
https://doi.org/10.1016/j.jconrel.2019.08.033
Autor:
David T. Omstead, Tanyel Kiziltepe, Basar Bilgicer, Baksun Kim, Jaeho Shin, Laurie E. Littlepage, Junmin Wu
Publikováno v:
J Control Release
Here, we report rationally engineered peptide-targeted liposomal doxorubicin nanoparticles that have an enhanced selectivity for HER2-positive breast tumor cells with high purity, reproducibility, and precision in controlling stoichiometry of targeti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c5afe8ca9a136ba25af3fef787faf1a
https://europepmc.org/articles/PMC7932755/
https://europepmc.org/articles/PMC7932755/
