Zobrazeno 1 - 10
of 65
pro vyhledávání: '"David T Humphreys"'
Autor:
Mahdi Moradi Marjaneh, Edwin P Kirk, Ralph Patrick, Dimuthu Alankarage, David T Humphreys, Gonzalo Del Monte-Nieto, Paola Cornejo-Paramo, Vaibhao Janbandhu, Tram B Doan, Sally L Dunwoodie, Emily S Wong, Chris Moran, Ian CA Martin, Peter C Thomson, Richard P Harvey
Publikováno v:
eLife, Vol 12 (2023)
Unlike single-gene mutations leading to Mendelian conditions, common human diseases are likely to be emergent phenomena arising from multilayer, multiscale, and highly interconnected interactions. Atrial and ventricular septal defects are the most co
Externí odkaz:
https://doaj.org/article/b0e177240240418384f4ea4e88aaa1c8
Autor:
David T Humphreys, Carly J Hynes, Hardip R Patel, Grace H Wei, Leah Cannon, Diane Fatkin, Catherine M Suter, Jennifer L Clancy, Thomas Preiss
Publikováno v:
PLoS ONE, Vol 7, Iss 2, p e30933 (2012)
microRNAs (miRNAs) are critical to heart development and disease. Emerging research indicates that regulated precursor processing can give rise to an unexpected diversity of miRNA variants. We subjected small RNA from murine HL-1 cardiomyocyte cells
Externí odkaz:
https://doaj.org/article/2fbe3c161a1b45d696c1a6ef16165a48
Autor:
Traude H Beilharz, David T Humphreys, Jennifer L Clancy, Rolf Thermann, David I K Martin, Matthias W Hentze, Thomas Preiss
Publikováno v:
PLoS ONE, Vol 4, Iss 8, p e6783 (2009)
Animal microRNAs (miRNAs) typically regulate gene expression by binding to partially complementary target sites in the 3' untranslated region (UTR) of messenger RNA (mRNA) reducing its translation and stability. They also commonly induce shortening o
Externí odkaz:
https://doaj.org/article/83ced30232c94b3c947cf5af2fba3c4b
Autor:
Ingrid Tarr, Stephanie Hesselson, Siiri E. Iismaa, Emma Rath, Steven Monger, Michael Troup, Ketan Mishra, Claire M.Y. Wong, Pei-Chen Hsu, Keerat Junday, David T. Humphreys, David Adlam, Tom R. Webb, Anna A. Baranowska-Clarke, Stephen E. Hamby, Keren J. Carss, Nilesh J. Samani, Monique Bax, Lucy McGrath-Cadell, Jason C. Kovacic, Sally L. Dunwoodie, Diane Fatkin, David W.M. Muller, Robert M. Graham, Eleni Giannoulatou
Publikováno v:
Circulation. Genomic and precision medicine. 15(4)
Background: Spontaneous coronary artery dissection (SCAD) is a cause of acute coronary syndrome that predominantly affects women. Its pathophysiology remains unclear but connective tissue disorders (CTD) and other vasculopathies have been observed in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa986447b04b2df8b621df51938acdb2
https://pubmed.ncbi.nlm.nih.gov/35980654
https://pubmed.ncbi.nlm.nih.gov/35980654
Autor:
Pietro Ridone, Tsubasa Ishida, Angela Lin, David T. Humphreys, Eleni Giannoulatou, Yoshiyuki Sowa, Matthew A. B. Baker
Publikováno v:
Science advances. 8(47)
Determining which cellular processes facilitate adaptation requires a tractable experimental model where an environmental cue can generate variants which rescue function. The Bacterial Flagellar Motor (BFM) is an excellent candidate – an ancient an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9dd679cf5bdb3a9d7bf777c545f9c263
https://pubmed.ncbi.nlm.nih.gov/36417540
https://pubmed.ncbi.nlm.nih.gov/36417540
Autor:
Mahdi Moradi Marjaneh, Edwin P. Kirk, Ralph Patrick, Dimuthu Alankerage, David T. Humphreys, Gonzalo Del Monte-Nieto, Paola Cornejo-Paramo, Vaibhao Janbandhu, Tram B. Doan, Sally L. Dunwoodie, Emily S. Wong, Chris Moran, Ian C.A. Martin, Peter C. Thomson, Richard P. Harvey
Unlike single-gene mutations leading to Mendelian conditions, common human diseases are likely emergent phenomena arising from multilayer, multiscale and highly interconnected interactions. Atrial and ventricular septal defects are the most common fo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ecb1d5ef3551c3b6e0b1bf051361d06f
https://doi.org/10.1101/2022.10.31.514499
https://doi.org/10.1101/2022.10.31.514499
Autor:
Andrian Yang, Dimuthu Alankarage, Hartmut Cuny, Eddie K.K. Ip, Moran Almog, Jessica Lu, Debjani Das, Annabelle Enriquez, Justin O. Szot, David T. Humphreys, Gillian M. Blue, Joshua W.K. Ho, David S. Winlaw, Sally L. Dunwoodie, Eleni Giannoulatou
Publikováno v:
Circulation: Genomic and Precision Medicine. 15
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5e7f54b93899b8913377970d78957fc
https://doi.org/10.1161/circgen.121.003539
https://doi.org/10.1161/circgen.121.003539
Autor:
Mark P. Hodson, Subhra Prakash Hui, Ozren Bogdanovic, Fan-Suo Geng, David T. Humphreys, Dawei Zheng, Maki Nakayama, Kotaro Sugimoto, Daniel Hesselson, Esther Kristianto, Yuxi Zhang, Kazu Kikuchi, Masahito Ogawa, Delicia Z. Sheng
Publikováno v:
Science. 372:201-205
Repairing the fish heart Although humans show minimal regenerative capability, zebrafish can regenerate their hearts through a mechanism whereby heart muscle cells (cardiomyocytes) revert to a less mature state and then proliferate to replace the dam
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c603c295caec0836e7760bc4be4d4e0
https://doi.org/10.1126/science.abe2762
https://doi.org/10.1126/science.abe2762
Autor:
Amy M. Nicks, Sara R. Holman, Andrea Y. Chan, Michael Tsang, Paul E. Young, David T. Humphreys, Nawazish Naqvi, Ahsan Husain, Ming Li, Nicola J. Smith, Siiri E. Iismaa, Robert M. Graham
Publikováno v:
Journal of molecular and cellular cardiology. 170
Primary cardiomyocytes are invaluable for understanding postnatal heart development. However, a universal method to obtain freshly purified cardiomyocytes without using different age-dependent isolation procedures and cell culture, is lacking. Here,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d772a1e215fa06fd61c129374d5dbd17
https://pubmed.ncbi.nlm.nih.gov/35644482
https://pubmed.ncbi.nlm.nih.gov/35644482
Autor:
Andrea Y. Chan, Sara R. Holman, Ahsan Husain, Paul E. Young, Nicola J. Smith, Siiri E. Iismaa, Ming Li, Robert M. Graham, Nawazish Naqvi, Michael Tsang, David T. Humphreys, Amy M Nicks
Rationale: Primary cardiomyocytes are invaluable for understanding postnatal heart development and elucidating disease mechanisms in genetic and pharmacological models, however, a method to obtain freshly purified cardiomyocytes at any postnatal age,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::82f7c595c5885a7569c9a86ca9c41151
https://doi.org/10.1101/2021.09.30.462562
https://doi.org/10.1101/2021.09.30.462562