Zobrazeno 1 - 10
of 114
pro vyhledávání: '"David T Dexter"'
Publikováno v:
PLoS Medicine, Vol 12, Iss 7, p e1001854 (2015)
BackgroundRecent in vitro and animal experiments suggest that peroxisome proliferation-activated receptor gamma (PPARɣ) agonist medications, such as antidiabetic glitazone (GTZ) drugs, are neuroprotective in models of Parkinson's disease (PD). These
Externí odkaz:
https://doaj.org/article/44dc44b57eed4d37979e48b5bd3d0021
Autor:
James Thomas Swingland, Pascal F Durrenberger, Richard eReynolds, David T Dexter, Ana ePombo, Manuel eDeprez, Federico eRoncaroli, Federico E. Turkheimer
Publikováno v:
Frontiers in Neuroscience, Vol 6 (2012)
Neurodegenerative diseases are characterised by neuronal loss. Neuronal loss causes a varying density of neurons across samples which confounds results from gene expression studies. Chromosome X is known to be specifically important in brain. We hypo
Externí odkaz:
https://doaj.org/article/73441f3cf9214677a543bba3e2fffa7e
Publikováno v:
npj Parkinson's Disease, Vol 9, Iss 1, Pp 1-14 (2023)
Abstract Parkinson’s disease (PD) is almost twice as prevalent in men, which has largely been attributed to neuroprotective effect of oestradiol in women. RORA (retinoic acid receptor-related orphan receptor alpha) regulates the transcription of ce
Externí odkaz:
https://doaj.org/article/bca815755fc14aa49f1f7cc08f9b4628
Autor:
Bradley Pearce, Peter Coetzee, Duncan Rowland, Scott Linfoot, David T Dexter, Djordje Gveric, Stephen Gentleman
The identification of Parkinson’s Disease (PD) from post-mortem brain slices is time consuming for highly trained neuropathologists, often taking many hours per case. In this study, we demonstrate fully automatic PD detection, from single 1000um re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::79edc7d8d7635fa36f3aac203093f8ef
https://doi.org/10.1101/2022.08.30.505459
https://doi.org/10.1101/2022.08.30.505459
Autor:
Caroline H. Williams-Gray, Diane Stephenson, Klaus Romero, Judith Anton, Ferdous Gheyas, Nathan J. Hanan, Jonas Weidemann, Minhua Yang, Malidi Ahamadi, Massimo Bani, Bob Stafford, Charles S. Venuto, Chao Chen, Vincent Thuillier, Ka Lai Yee, Gennaro Pagano, Monica Javidnia, Sreeraj Macha, Nitin Mehrotra, Vikram Sinha, Kenneth Marek, Yaming Hang, Hans Smit, Anne Pedata, Mussie Akalu, Babak Boroojerdi, David T. Dexter, Glenn T. Stebbins
Publikováno v:
Clinical Pharmacology & Therapeutics. 110:508-518
Leucine-rich repeat kinase 2 (LRRK2) inhibitors are currently in clinical development as interventions to slow progression of Parkinson's disease (PD). Understanding the rate of progression in PD as measured by both motor and non-motor features is pa
Publikováno v:
International journal of molecular sciences. 23(13)
Disturbance of the brain homeostasis, either directly via the formation of abnormal proteins or cerebral hypo-perfusion, or indirectly via peripheral inflammation, will activate microglia to synthesise a variety of pro-inflammatory agents which may l
Autor:
Roberta J. Ward, Antonio Martin-Bastida, David T. Dexter, Sukhi Bansal, Bension S. Tilley, Steve M. Gentleman
Publikováno v:
Journal of Neural Transmission. 128:15-25
In these present studies, in vivo and and post-mortem studies have investigated the association between iron and inflammation. Early-stage Parkinson’s disease (PD) patients, of less than 5 years disease duration, showed associations of plasmatic fe
Autor:
Brian K. Fiske, Simon R.W. Stott, Mart Saarma, Camille Carroll, David Eidelberg, Roger A. Barker, Richard K. Wyse, Patrik Brundin, Amber D. Van Laar, Jamie L. Eberling, David T Dexter, Henri J. Huttunen, Merja H. Voutilainen, Adrian P. Kells, Jeffrey H. Kordower, Eros Bresolin, Alasdair Coles, Leah Mursaleen, Don M. Gash, Karl Kieburtz, Alan L Whone, Howard J. Federoff, A. Jon Stoessl, Sigrid Booms, Lyndsey Isaacs, Massimo S. Fiandaca, Anthony E. Lang, Codrin Lungu, Krystof S. Bankiewicz, Helen Matthews, Anders Björklund
Publikováno v:
Journal of Parkinson's disease, vol 10, iss 3
Barker, R A, Bjorklund, A, Gash, D M, Whone, A, Van Laar, A, Kordower, J H, Bankiewicz, K, Kieburtz, K, Saarma, M, Booms, S, Huttunen, H J, Kells, A, Fiandaca, M S, Stoessl, A J, Eidelberg, D, Federoff, H, Voutilainen, M, Dexter, D T, Eberling, J, Brundin, P, Isaacs, L, Mursaleen, L, Bresolin, E, Carroll, C, Coles, A, Fiske, B, Matthews, H, Lungu, C, Wyse, R K, Stott, S & Lang, A E 2020, ' GDNF and Parkinson's Disease : Where Next? A Summary from a Recent Workshop ', Journal of Parkinson's Disease, vol. 10, no. 3, pp. 875-891 . https://doi.org/10.3233/JPD-202004
Journal of Parkinson's Disease
Barker, R A, Bjorklund, A, Gash, D M, Whone, A, Van Laar, A, Kordower, J H, Bankiewicz, K, Kieburtz, K, Saarma, M, Booms, S, Huttunen, H J, Kells, A, Fiandaca, M S, Stoessl, A J, Eidelberg, D, Federoff, H, Voutilainen, M, Dexter, D T, Eberling, J, Brundin, P, Isaacs, L, Mursaleen, L, Bresolin, E, Carroll, C, Coles, A, Fiske, B, Matthews, H, Lungu, C, Wyse, R K, Stott, S & Lang, A E 2020, ' GDNF and Parkinson's Disease : Where Next? A Summary from a Recent Workshop ', Journal of Parkinson's Disease, vol. 10, no. 3, pp. 875-891 . https://doi.org/10.3233/JPD-202004
Journal of Parkinson's Disease
The concept of repairing the brain with growth factors has been pursued for many years in a variety of neurodegenerative diseases including primarily Parkinson's disease (PD) using glial cell line-derived neurotrophic factor (GDNF). This neurotrophic
Autor:
Michael Lindemann, Robert Alexander, Babak Boroojerdi, Jackson Burton, Marissa F. Dockendorf, Lisa J. Bain, Jesse M. Cedarbaum, George Roussos, Eiichi Sengoku, Joseph Scheeren, Kirsten I. Taylor, Diane Stephenson, Klaus Romero, Nitin Mehrotra, Josh Cosman, Beatrice T. Yang, Robert Rubens, Varun Aggarwal, Marjan J. Meinders, Janice Hitchcock, Ariel V. Dowling, Mark Frasier, Tanya Simuni, Neta Zach, Ken Marek, Sakshi Sadar, Jennifer C. Goldsack, Michele T.M. Hu, Katherine J. Fisher, Michael P. Lawton, Derek L. G. Hill, David T. Dexter, Reham Badawy, Luis Garcia-Gancedo, Luc J.W. Evers, Bastiaan R. Bloem, Michael Minchik, Glenn T. Stebbins, Roopal Bhatnagar, E. Ray Dorsey, Lauren Oliva, Susan J. Lee
Publikováno v:
Digital Biomarkers, 4, 28-49
Digital Biomarkers, Vol 4, Iss 1, Pp 28-49 (2020)
Digital Biomarkers, 4, 1, pp. 28-49
Digit Biomark
Digital Biomarkers, Vol 4, Iss 1, Pp 28-49 (2020)
Digital Biomarkers, 4, 1, pp. 28-49
Digit Biomark
Contains fulltext : 229477.pdf (Publisher’s version ) (Open Access) Innovative tools are urgently needed to accelerate the evaluation and subsequent approval of novel treatments that may slow, halt, or reverse the relentless progression of Parkinso
Autor:
Romeo Maciuca, Rachael A Lawson, Timothy Nicholas, David T. Dexter, Malidi Ahamadi, Chao Chen, David J. Burn, Kenneth Marek, Minhua Yang, Klaus Romero, Bob Stafford, Sreeraj Macha, Julie A. Stone, Diane Stephenson, Jackson Burton, Daniela J. Conrado, Vikram Sinha, Hans Smit, Massimo Bani, Mussie Akalu, Jill Gallagher, Babak Boroojerdi, Jonas Weidemann, Charles S. Venuto
Publikováno v:
Clin Pharmacol Ther
A quantitative assessment of Parkinson’s disease (PD) progression is critical for optimizing clinical trials design. Disease progression model was developed using pooled data from the Progression Marker Initiative study and the Incidence of Cogniti