Zobrazeno 1 - 10
of 223
pro vyhledávání: '"David T, Breault"'
Autor:
Jianbo Zhang, Yu-Ja Huang, Martin Trapecar, Charles Wright, Kirsten Schneider, John Kemmitt, Victor Hernandez-Gordillo, Jun Young Yoon, Mathilde Poyet, Eric J. Alm, David T. Breault, David L. Trumper, Linda G. Griffith
Publikováno v:
npj Biofilms and Microbiomes, Vol 10, Iss 1, Pp 1-11 (2024)
Abstract Crosstalk of microbes with human gut epithelia and immune cells is crucial for gut health. However, there is no existing system for a long-term co-culture of human innate immune cells with epithelium and oxygen-intolerant commensal microbes,
Externí odkaz:
https://doaj.org/article/f385e88a79b24dc9bc17f31a90057b1f
Autor:
Amy E. O’Connell, Sathuwarman Raveenthiraraj, Luiz Fernando Silva Oliveira, Comfort Adegboye, Venkata Siva Dasuri, Wanshu Qi, Radhika S. Khetani, Akaljot Singh, Nambirajam Sundaram, Jasmine Lin, Prathima Nandivada, Lorena Rincón-Cruz, Jeffrey D. Goldsmith, Jay R. Thiagarajah, Diana L. Carlone, Jerrold R. Turner, Pankaj B. Agrawal, Michael Helmrath, David T. Breault
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 18, Iss 2, Pp 101349- (2024)
Background & aims: Humans with WNT2B deficiency have severe intestinal disease, including significant inflammatory injury, highlighting a critical role for WNT2B. We sought to understand how WNT2B contributes to intestinal homeostasis. Methods: We in
Externí odkaz:
https://doaj.org/article/73ecaa07cd064534a6b295fa2a02c92d
Autor:
Seongmin Kim, Arash Naziripour, Pranav Prabhala, Viktor Horváth, Abidemi Junaid, David T. Breault, Girija Goyal, Donald E. Ingber
Publikováno v:
EBioMedicine, Vol 99, Iss , Pp 104921- (2024)
Summary: Background: Sulfadoxine-pyrimethamine (SP) antimalarial therapy has been suggested to potentially increase the birth weight of infants in pregnant women in sub-Saharan Africa, independently of malarial infection. Here, we utilized female int
Externí odkaz:
https://doaj.org/article/1052d97ecf594f1d99ffcccef20f927c
Autor:
Gerard Ruiz-Babot, Ariane Eceiza, Fernando Abollo-Jiménez, Maria Malyukov, Diana L. Carlone, Kleiton Borges, Alexandra Rodrigues Da Costa, Shamma Qarin, Takuya Matsumoto, Ryuji Morizane, William C. Skarnes, Barbara Ludwig, Paul J. Chapple, Leonardo Guasti, Helen L. Storr, Stefan R. Bornstein, David T. Breault
Publikováno v:
Cell Reports: Methods, Vol 3, Iss 11, Pp 100627- (2023)
Summary: Adrenal insufficiency is a life-threatening condition resulting from the inability to produce adrenal hormones in a dose- and time-dependent manner. Establishing a cell-based therapy would provide a physiologically responsive approach for th
Externí odkaz:
https://doaj.org/article/6ac601e73ba74f568125dbf81561e3a8
Autor:
Damien Dufour, Typhanie Dumontet, Isabelle Sahut-Barnola, Aude Carusi, Méline Onzon, Eric Pussard, James Jr Wilmouth, Julie Olabe, Cécily Lucas, Adrien Levasseur, Christelle Damon-Soubeyrand, Jean-Christophe Pointud, Florence Roucher-Boulez, Igor Tauveron, Guillaume Bossis, Edward T. Yeh, David T. Breault, Pierre Val, Anne-Marie Lefrançois-Martinez, Antoine Martinez
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)
SUMOylation is a mechanism of posttranslational modification involved in eukaryotic cell homeostasis. Here the authors report that mice unable to control SUMOylation in the adrenal cortex develop a selective defect in glucocorticoid production due to
Externí odkaz:
https://doaj.org/article/94675fdf0b57490d98010c427e95a3d3
Autor:
Songhai Tian, Xiaozhe Xiong, Ji Zeng, Siyu Wang, Benjamin Jean-Marie Tremblay, Peng Chen, Baohua Chen, Min Liu, Pengsheng Chen, Kuanwei Sheng, Daniel Zeve, Wanshu Qi, David T. Breault, César Rodríguez, Ralf Gerhard, Rongsheng Jin, Andrew C. Doxey, Min Dong
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-19 (2022)
Abstract Toxin B (TcdB) is a major exotoxin responsible for diseases associated with Clostridioides difficile infection. Its sequence variations among clinical isolates may contribute to the difficulty in developing effective therapeutics. Here, we i
Externí odkaz:
https://doaj.org/article/794a66b7501d4c9db6602d45ebb015c0
Autor:
Mesut Berber, Sining Leng, Agnieszka Wengi, Denise V. Winter, Alex Odermatt, Felix Beuschlein, Johannes Loffing, David T. Breault, David Penton
Publikováno v:
JCI Insight, Vol 8, Iss 14 (2023)
The mineralocorticoid aldosterone, secreted by the adrenal zona glomerulosa (ZG), is critical for life, maintaining ion homeostasis and blood pressure. Therapeutic inhibition of protein phosphatase 3 (calcineurin, Cn) results in inappropriately low p
Externí odkaz:
https://doaj.org/article/17c862d14a5b4e46b23bf19918c8d968
Autor:
Carlos Sebastian, Christina Ferrer, Maria Serra, Jee-Eun Choi, Nadia Ducano, Alessia Mira, Manasvi S. Shah, Sylwia A. Stopka, Andrew J. Perciaccante, Claudio Isella, Daniel Moya-Rull, Marianela Vara-Messler, Silvia Giordano, Elena Maldi, Niyati Desai, Diane E. Capen, Enzo Medico, Murat Cetinbas, Ruslan I. Sadreyev, Dennis Brown, Miguel N. Rivera, Anna Sapino, David T. Breault, Nathalie Y. R. Agar, Raul Mostoslavsky
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-13 (2022)
Metabolic reprogramming upon SIRT6 loss induces tumour formation in the intestine but the mechanism is unclear. Here, the authors show that loss of SIRT6 leads to the expansion of epithelial cells with high pyruvate dehydrogenase kinase activity resu
Externí odkaz:
https://doaj.org/article/1ae650e5a5c942e78cc7775f36dd9685
Autor:
Daniel Zeve, Eric Stas, Joshua de Sousa Casal, Prabhath Mannam, Wanshu Qi, Xiaolei Yin, Sarah Dubois, Manasvi S. Shah, Erin P. Syverson, Sophie Hafner, Jeffrey M. Karp, Diana L. Carlone, Jose Ordovas-Montanes, David T. Breault
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-20 (2022)
Hormone-producing enteroendocrine cells (EEC) regulate of energy homeostasis and gastrointestinal function. Here the authors report protocols to induce human intestinal stem cells into EECs producing multiple gut hormones, including SST, 5-HT, CCK an
Externí odkaz:
https://doaj.org/article/5df1633f42064afa9e128b2699a872f8
Autor:
Nick A. Guagliardo, Peter M. Klein, Christina A. Gancayco, Adam Lu, Sining Leng, Rany R. Makarem, Chelsea Cho, Craig G. Rusin, David T. Breault, Paula Q. Barrett, Mark P. Beenhakker
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
Aldosterone-producing zona glomerulosa cells in the adrenal gland arrange into rosette structures known to be important for morphogenesis. Here the authors show that the cells in the rosettes produce coordinated calcium activity bursts in response to
Externí odkaz:
https://doaj.org/article/c1975079f3f541bbb5287c6fb622c60d