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Autor:
Arco Y. Jeng, Ying Qiao, Paula Savage, Michael A. Moskal, Michael E. Beil, Angelo J. Trapani, Fariborz Firooznia, Hoyer Denton W, Cynthia A. Fink, Dongchu Wei, David Symonsbergen
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 10:2037-2039
Through directed screening of compounds prepared as metalloprotease inhibitors a compound, CGS 30084 , that had potent endothelin converting enzyme-1 (ECE-1) in vitro inhibitory activity (IC 50 =77 nM) was identified. Herein we report the synthesis a