Zobrazeno 1 - 10
of 15
pro vyhledávání: '"David Sweedler"'
Autor:
Vann P. Parker, Ernest C. Borden, David Sweedler, Karin S. Blanchard, Jennifer A. Sandberg, Lawrence M. Blatt, Nassim Usman, James A. Powell, Laurent Bellon, Arlee Kachensky, Thomas Rossing
Publikováno v:
The Journal of Clinical Pharmacology. 40:1462-1469
The pharmacokinetics and tolerability of a chemically stabilized synthetic ribozyme (ANGIOZYME ) targeting the Flt-1 VEGF receptor mRNA were evaluated in healthy volunteers. In a placebo-controlled, single-dose escalation study, ribozyme was administ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3731c43b3db54a409cbe2c537a1142fc
https://doi.org/10.1177/009127000004001217
https://doi.org/10.1177/009127000004001217
Autor:
Tom J. Parry, Karin S. Blanchard, Vann P. Parker, Florence A. Caputo, David Sweedler, Christopher D. Sproul, Douglas J. Kornbrust, James A. Powell, Laurent Bellon, Jennifer A. Sandberg, Lawrence M. Blatt
Publikováno v:
Antisense and Nucleic Acid Drug Development. 10:153-162
The potential acute toxicity of a ribozyme (ANGIOZYME) targeting the flt-1 vascular endothelial growth factor (VEGF) receptor mRNA was evaluated in cynomolgus monkeys following i.v. infusion or s.c. injection. ANGIOZYME was administered as a 4-hour i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e4412205fe955f25f37715f41354e64
https://doi.org/10.1089/oli.1.2000.10.153
https://doi.org/10.1089/oli.1.2000.10.153
Functionalized nucleoside 5′-triphosphates for in vitro selection of new catalytic ribonucleic acids
Autor:
Andrew T. Daniher, David Sweedler, Alexander Karpeisky, Peter Haeberli, Jasenka Matulic-Adamic, Leonid Beigelman
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 10:1299-1302
A series of novel 2'-modified nucleoside 5'-triphosphates was synthesized. The amino, imidazole, and carboxylate functionalities were attached to the 5-position of pyrimidine base of these molecules through alkynyl and alkyl spacers, respectively. Tw
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::786b6534a84be03f763b185b535b2c7e
https://doi.org/10.1016/s0960-894x(00)00226-2
https://doi.org/10.1016/s0960-894x(00)00226-2
Publikováno v:
Tetrahedron. 56:1047-1056
We developed several improved approaches toward 2′- O -methyl adenosine and guanosine and their N -acyl derivatives. (a) Transglycosylation of N 4 -acetyl-5′, 3′-di- O -acetyl-2′- O -methyl cytidine with N 6 -Bz-adenine provided N 6 -benzoyl-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::326ec0c6e4a13b8231ffda7a21e06954
https://doi.org/10.1016/s0040-4020(00)00002-8
https://doi.org/10.1016/s0040-4020(00)00002-8
Autor:
Leonid Beigelman, Alexander Karpeisky, James McSwiggen, Varykina G. Thackray, Kristi Jensen, Francine E. Wincott, Nassim Usman, Jasenka Matulic-Adamic, Kenneth G. Draper, Danuta Tracz, David Sweedler, Anil S. Modak, Carolyn Gonzalez, Susan Grimm, Peter Haeberli, Anthony DiRenzo
Publikováno v:
Journal of Biological Chemistry. 270:25702-25708
A systematic study of selectively modified, 36-mer hammerhead ribozymes has resulted in the identification of a generic, catalytically active and nuclease stable ribozyme motif containing 5 ribose residues, 29-30 2'-O-Me nucleotides, 1-2 other 2'-mod
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b563082f8196c9a4f0a152c6135a6ce7
https://doi.org/10.1074/jbc.270.43.25702
https://doi.org/10.1074/jbc.270.43.25702
Autor:
Francine Wincott, Anthony DiRenzo, Chris Shaffer, Susan Grimm, Danuta Tracz, Christopher Workman, David Sweedler, Carolyn Gonzalez, Stephen Scaringe, Nassim Usman
Publikováno v:
Nucleic Acids Research. 23:2677-2684
Improvements in the synthesis, deprotection and purification of oligoribonucleotides are described. These advances allow for reduced synthesis and deprotection times, while improving product yield. Coupling times are reduced by half using 5-ethylthio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dec781c03e2989361dc7a62305a92e34
https://doi.org/10.1093/nar/23.14.2677
https://doi.org/10.1093/nar/23.14.2677
Autor:
Jasenka Matulic-Adamic, Nassim Usman, P. Haeberli, David Sweedler, Leonid Beigelman, Alexander Karpeisky
Publikováno v:
Nucleic Acids Research. 23:4434-4442
Several 2'-modified ribonucleoside phosphoramidites have been prepared for structure-activity studies of the hammerhead ribozyme. The aim of these studies was to design and synthesize catalytically active and nuclease-resistant ribozymes. Synthetic s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e09af713e6d41804aa6377bceae24ad4
https://doi.org/10.1093/nar/23.21.4434
https://doi.org/10.1093/nar/23.21.4434
Autor:
Peter Haeberli, Keith Jarvis, Alexander Karpeisky, David Sweedler, Leonid Beigelman, Javier Read
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 12:3345-3347
2'-Deoxy-2'-N-phthaloyl nucleosides were prepared from arabino nucleosides by triflate displacement with phthalimide in the presence of DBU. The corresponding phosphoramidites suitable for automated oligonucleotide synthesis were also synthesized. Th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1521acf034715aed60d1bb53bb62d68
https://doi.org/10.1016/s0960-894x(02)00744-8
https://doi.org/10.1016/s0960-894x(02)00744-8
Autor:
Alexander Karpeisky, Andrew T. Daniher, Jasenka Matulic-Adamic, Peter Haeberli, Leonid Beigelman, David Sweedler
Publikováno v:
Nucleosides, Nucleotides and Nucleic Acids. 20:1113-1115
2′-Modified pyrimidine nucleoside 5′-triphosphates comprising amino, imidazole and carboxylate functionality attached to the 5-position of the base were synthesized. Two different phosphorylation methods were used to optimize the yields of these
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e25db45e6ace09df9895dc8c308e16ae
https://doi.org/10.1081/ncn-100002500
https://doi.org/10.1081/ncn-100002500
Publikováno v:
ChemInform. 31
We developed several improved approaches toward 2′- O -methyl adenosine and guanosine and their N -acyl derivatives. (a) Transglycosylation of N 4 -acetyl-5′, 3′-di- O -acetyl-2′- O -methyl cytidine with N 6 -Bz-adenine provided N 6 -benzoyl-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a1e34e7c6a25546f6ed9a1aa09e3ba1f
https://doi.org/10.1002/chin.200023223
https://doi.org/10.1002/chin.200023223