Zobrazeno 1 - 10
of 78
pro vyhledávání: '"David Surguladze"'
Autor:
Michael E. Stokes, Matthew D. Surman, Veronica Calvo, David Surguladze, An-Hu Li, Jennifer Gasparek, Matthew Betzenhauser, Guangyu Zhu, Hongwen Du, Alan C. Rigby, Mark J. Mulvihill
Publikováno v:
Pharmaceutics, Vol 14, Iss 10, p 2233 (2022)
The protein kinase R (PKR)-like endoplasmic reticulum kinase (PERK) is one of three endoplasmic reticulum (ER) transmembrane sensors of the unfolded protein response (UPR) responsible for regulating protein synthesis and alleviating ER stress. PERK h
Externí odkaz:
https://doaj.org/article/bfdce10972624d15be3669c45666742f
Autor:
Rikke B. Holmgaard, David A. Schaer, Yanxia Li, Stephen P. Castaneda, Mary Y. Murphy, Xiaohong Xu, Ivan Inigo, Julie Dobkin, Jason R. Manro, Philip W. Iversen, David Surguladze, Gerald E. Hall, Ruslan D. Novosiadly, Karim A. Benhadji, Gregory D. Plowman, Michael Kalos, Kyla E. Driscoll
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 6, Iss 1, Pp 1-15 (2018)
Abstract Background TGFβ signaling plays a pleotropic role in tumor biology, promoting tumor proliferation, invasion and metastasis, and escape from immune surveillance. Inhibiting TGFβ’s immune suppressive effects has become of particular intere
Externí odkaz:
https://doaj.org/article/add74ac3d1f847239e42c3dd99f9f142
Autor:
Yiwen Li, Carmine Carpenito, George Wang, David Surguladze, Amelie Forest, Maria Malabunga, Mary Murphy, Yiwei Zhang, Andreas Sonyi, Darin Chin, Douglas Burtrum, Ivan Inigo, Anthony Pennello, Leyi Shen, Laurent Malherbe, Xinlei Chen, Gerald Hall, Jaafar N. Haidar, Dale L. Ludwig, Ruslan D. Novosiadly, Michael Kalos
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 6, Iss 1, Pp 1-14 (2018)
Abstract Background Modulation of the PD-1/PD-L1 axis through antagonist antibodies that block either receptor or ligand has been shown to reinvigorate the function of tumor-specific T cells and unleash potent anti-tumor immunity, leading to durable
Externí odkaz:
https://doaj.org/article/23eb068b1c80433fb11267b151e41edf
Autor:
Inga J. Duignan, Erik Corcoran, Anthony Pennello, Mary Jane Plym, Michael Amatulli, Nidia Claros, Michelle Iacolina, Hagop Youssoufian, Larry Witte, Selda Samakoglu, Jonathan Schwartz, David Surguladze, James R. Tonra
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 13, Iss 1, Pp 49-59 (2011)
The benefits of inhibiting vascular endothelial growth factor (VEGF) signaling in cancer patients are predominantly attributed to effects on tumor endothelial cells. Targeting non–endothelial stromal cells to further impact tumor cell growth and su
Externí odkaz:
https://doaj.org/article/4d7f4f7b9cc14e00ab7edc9c7481333c
Autor:
Yiwen Li, Carmine Carpenito, George Wang, David Surguladze, Amelie Forest, Maria Malabunga, Mary Murphy, Yiwei Zhang, Andreas Sonyi, Darin Chin, Douglas Burtrum, Ivan Inigo, Anthony Pennello, Leyi Shen, Laurent Malherbe, Xinlei Chen, Gerald Hall, Jaafar N. Haidar, Dale L. Ludwig, Ruslan D. Novosiadly, Michael Kalos
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 6, Iss 1, Pp 1-1 (2018)
Unfortunately, after publication of this article [1], it was noticed that corrections to the legends of Figs. 1 and 2 were not correctly incorporated. The correct legends can be seen below.
Externí odkaz:
https://doaj.org/article/fdf1b617c54c4afb9fbc0522a222a977
Autor:
Michael Kalos, Dale L. Ludwig, Gregory D. Plowman, Christopher M. Moxham, Ruslan D. Novosiadly, Jaafar N. Haidar, Andreas Sonyi, Darin Chin, Stacy Torgerson, Bing Han, Yanbin Lao, Tim Bailey, Danielle K. Bulaon, Yiwei Zhang, Xinlei Chen, Michael Topper, Sagit Hindi, Krishnadatt Persaud, Anthony L. Pennello, David Surguladze, Ivan Inigo, George Wang, Yang Shen, Scott W. Eastman, Carmine Carpenito, Maria Malabunga, Yiwen Li, Helen Kotanides
The programmed cell death protein 1 receptor (PD-1) and programmed death ligand 1 (PD-L1) coinhibitory pathway suppresses T-cell–mediated immunity. We hypothesized that cotargeting of PD-1 and PD-L1 with a bispecific antibody molecule could provide
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1986ead76832948fc92b79c10618c0e0
https://doi.org/10.1158/2326-6066.c.6550090
https://doi.org/10.1158/2326-6066.c.6550090
Autor:
Michael Kalos, Dale L. Ludwig, Gregory D. Plowman, Christopher M. Moxham, Ruslan D. Novosiadly, Jaafar N. Haidar, Andreas Sonyi, Darin Chin, Stacy Torgerson, Bing Han, Yanbin Lao, Tim Bailey, Danielle K. Bulaon, Yiwei Zhang, Xinlei Chen, Michael Topper, Sagit Hindi, Krishnadatt Persaud, Anthony L. Pennello, David Surguladze, Ivan Inigo, George Wang, Yang Shen, Scott W. Eastman, Carmine Carpenito, Maria Malabunga, Yiwen Li, Helen Kotanides
Supplementary Figures 1-9 and Supplementary Tables 1-3
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ae9b70f08e357e6f6d0737e3afa7b80
https://doi.org/10.1158/2326-6066.22542937.v1
https://doi.org/10.1158/2326-6066.22542937.v1
Autor:
Michael Kalos, Gregory D. Plowman, Dale L. Ludwig, Ruslan D. Novosiadly, Douglas Burtrum, Yiwei Zhang, Prachi Sharma, Lauren Boucher, Michael Topper, Andreas Sonyi, Darin Chin, Xinlei Chen, Amelie Forest, Anthony L. Pennello, Ivan Inigo, Leyi Shen, Colleen Burns, Jaafar N. Haidar, David Surguladze, Jingxing Li, Juqun Shen, Carmine Carpenito, Maria B. Lebron, Rose Marie Sattler, Helen Kotanides
Figure S3 shows CD137 receptor modulation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c3bb6a3afe5cfbbb01f18d1ddaccd41
https://doi.org/10.1158/1535-7163.22519410
https://doi.org/10.1158/1535-7163.22519410
Autor:
Michael Kalos, Gregory D. Plowman, Dale L. Ludwig, Ruslan D. Novosiadly, Douglas Burtrum, Yiwei Zhang, Prachi Sharma, Lauren Boucher, Michael Topper, Andreas Sonyi, Darin Chin, Xinlei Chen, Amelie Forest, Anthony L. Pennello, Ivan Inigo, Leyi Shen, Colleen Burns, Jaafar N. Haidar, David Surguladze, Jingxing Li, Juqun Shen, Carmine Carpenito, Maria B. Lebron, Rose Marie Sattler, Helen Kotanides
Table S2 shows human immune effector ADCC and CDC activity EC50 (nM)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76a7d8844ae274ecd96486d49338c0e0
https://doi.org/10.1158/1535-7163.22519383
https://doi.org/10.1158/1535-7163.22519383
Autor:
Ruslan Novosiadly, Malcolm A. Smith, Peter J. Houghton, James T. DeLigio, David Surguladze, Marie C. Prewett, Heinz H. Fiebig, Nina Zanella, Gregory P. Donoho, Colleen A. Burns, Ying Wang, Christopher B. Damoci, Dale L. Ludwig, Michael Amatulli, Amelie Forest
Supplemental Tables 1-2 & Figures 1-4. Supplemental Table 1. Total IR, IR-A, IR-B, IGF-IR, IGF-I and IGF-II mRNA expression in preclinical models of pediatric solid tumors. Supplemental Table 2. Patient-derived xenograft models of lung adenocarcinoma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a081c5e60efb4377fed1664d1b1a0c24
https://doi.org/10.1158/1541-7786.22511881.v1
https://doi.org/10.1158/1541-7786.22511881.v1