Zobrazeno 1 - 10
of 27
pro vyhledávání: '"David Steadman"'
Autor:
Nicky J. Willis, Elliott D. Bayle, George Papageorgiou, David Steadman, Benjamin N. Atkinson, William Mahy, Paul V. Fish
Publikováno v:
Beilstein Journal of Organic Chemistry, Vol 15, Iss 1, Pp 2790-2797 (2019)
Background: The carboxylesterase Notum has been shown to act as a key negative regulator of the Wnt signalling pathway by mediating the depalmitoleoylation of Wnt proteins. LP-922056 (1) is an orally active inhibitor of Notum. We are investigating th
Externí odkaz:
https://doaj.org/article/0e99894a7cf64cf9a6e14cd7a002f112
Autor:
David Steadman, Jeff Ingalls
About This BookGet to grips with the basics of identity management and get acquainted with the MIM components and functionalitiesDiscover the newly-introduced product features and how they can help your organizationA step-by-step guide to enhance you
Autor:
H. Gregory McDonald, David Steadman
Publikováno v:
Historical Biology. :1-9
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8045e69c6edec6a084d527fa56314918
https://doi.org/10.1080/08912963.2022.2103694
https://doi.org/10.1080/08912963.2022.2103694
Autor:
Benjamin N. Atkinson, Fredrik Svensson, Hannah Woodward, Paul Whiting, Elliott D. Bayle, Paul V. Fish, Nicky J. Willis, Jean-Paul Vincent, David Steadman
Publikováno v:
Journal of Medicinal Chemistry
Regulation of the Wnt signaling pathway is critically important for a number of cellular processes in both development and adult mammalian biology. This Perspective will provide a summary of current and emerging therapeutic opportunities in modulatin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1daca6a8ed39142ac3fc8a7145d74588
https://doi.org/10.1021/acs.jmedchem.0c01974
https://doi.org/10.1021/acs.jmedchem.0c01974
Autor:
Yuguang Zhao, William Mahy, Nicky J. Willis, Hannah L. Woodward, David Steadman, Elliott D. Bayle, Benjamin N. Atkinson, James Sipthorp, Luca Vecchia, Reinis R. Ruza, Karl Harlos, Fiona Jeganathan, Stefan Constantinou, Artur Costa, Svend Kjær, Magda Bictash, Patricia C. Salinas, Paul Whiting, Jean-Paul Vincent, Paul V. Fish, E. Yvonne Jones
The Wnt signaling suppressor Notum is a promising target for osteoporosis, Alzheimer's disease, and colorectal cancers. To develop novel Notum inhibitors, we used an X-ray crystallographic fragment screen with the Diamond-SGC Poised Library (DSPL) an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f547dc38fab64d9f08bf48b45b75fa9e
Autor:
David Steadman, Benjamin N. Atkinson, Yuguang Zhao, Nicky J. Willis, Sarah Frew, Amy Monaghan, Chandni Patel, Emma Armstrong, Kathryn Costelloe, Lorenza Magno, Magda Bictash, E. Yvonne Jones, Paul V. Fish, Fredrik Svensson
Publikováno v:
Journal of medicinal chemistry. 65(1)
Notum is a negative regulator of Wnt signaling acting through the hydrolysis of a palmitoleoylate ester, which is required for Wnt activity. Inhibitors of Notum could be of use in diseases where dysfunctional Notum activity is an underlying cause. A
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40edd35a69ac0b95580d171b01ebf3b1
https://pubmed.ncbi.nlm.nih.gov/34939789
https://pubmed.ncbi.nlm.nih.gov/34939789
Autor:
Roberto Icken Hernández López, Armando Cázares-Körner, Paul A. Dalby, David Steadman, Daniel Méndez-Sánchez, Helen C. Hailes, Haoran Yu, Tom D. Sheppard, Sally Higson, John M. Ward
Publikováno v:
The FEBS Journal. 287:1758-1776
A narrow substrate range is a major limitation in exploiting enzymes more widely as catalysts in synthetic organic chemistry. For enzymes using two substrates, the simultaneous optimisation of both substrate specificities is also required for the rap
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e98884f7d3d784d83a586f00766c2f99
https://doi.org/10.1111/febs.15108
https://doi.org/10.1111/febs.15108
Autor:
Benjamin N. Atkinson, Paul V. Fish, David Steadman, Fredrik Svensson, James Hillier, Nicky J. Willis, A Costa, M Patel, Amy Monaghan, A Flint, Hannah Woodward, S. Frew, Reinis R. Ruza, William Mahy, M W Walter, D Papatheodorou, Magda Bictash, Yuguang Zhao, E Y Jones, L. Vecchia
Publikováno v:
Journal of medicinal chemistry. 63(17)
The Wnt family of proteins are secreted signaling proteins that play key roles in regulating cellular functions. Recently, carboxylesterase Notum was shown to act as a negative regulator of Wnt signaling by mediating the removal of an essential palmi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f1490ab55dc83d203fbb243d97d8f076
https://pubmed.ncbi.nlm.nih.gov/32787107
https://pubmed.ncbi.nlm.nih.gov/32787107
Autor:
Roberto Icken Hernández López, Sally Higson, Armando Cázares-Körner, Daniel Méndez-Sánchez, David Steadman, John M. Ward, Helen C. Hailes, Haoran Yu, Paul A. Dalby
A narrow substrate range is a major limitation in exploiting enzymes more widely as catalysts in synthetic organic chemistry. For enzymes using two substrates, the simultaneous optimization of both substrate specificities, is also required for the ra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60f64b170f47bddbdff75757c9aca969
https://doi.org/10.1101/719906
https://doi.org/10.1101/719906
Autor:
George Papageorgiou, Paul V. Fish, Elliott D. Bayle, David Steadman, Benjamin N. Atkinson, Nicky J. Willis, William Mahy
Publikováno v:
Beilstein Journal of Organic Chemistry, Vol 15, Iss 1, Pp 2790-2797 (2019)
Beilstein Journal of Organic Chemistry
Beilstein Journal of Organic Chemistry
Background: The carboxylesterase Notum has been shown to act as a key negative regulator of the Wnt signalling pathway by mediating the depalmitoleoylation of Wnt proteins. LP-922056 (1) is an orally active inhibitor of Notum. We are investigating th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac8d0fd0c21aef274fede3dc203ef510
https://doi.org/10.3762/bxiv.2019.70.v1
https://doi.org/10.3762/bxiv.2019.70.v1