Zobrazeno 1 - 10
of 22
pro vyhledávání: '"David Standring"'
Autor:
Elodie Rosinovsky, Catherine Caillet, Chiara Musiu, Jingyang Wang, Marie-Pierre Lioure, Arlène Roland, Luana Vargiu, Jocelyn Jakubik, Alistair Stewart, Michel Liuzzi, Richard Storer, Stéphanie Bot, Daniel Da Costa, Sébastien Maldonado, Barbara Poddesu, David Standring, Christophe Claude Parsy, Cyril B. Dousson, Christophe Trochet, Séverine Bonaric, Francois-Rene Alexandre, Maria Seifer, Adel Moussa, Benjamin Alexander Mayes, Agnès Amador, Luke Hubbard, Thierry Convard
Publikováno v:
Journal of Medicinal Chemistry. 59:1891-1898
Here, we describe the design, synthesis, biological evaluation, and identification of a clinical candidate non-nucleoside reverse transcriptase inhibitors (NNRTIs) with a novel aryl-phospho-indole (APhI) scaffold. NNRTIs are recommended components of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::176c9163cb45c8243cc2fc43da5fe84d
https://doi.org/10.1021/acs.jmedchem.5b01430
https://doi.org/10.1021/acs.jmedchem.5b01430
Autor:
Thierry Convard, L.B. Lallos, Florence Bonnaterre, Valérie Bidau, Houcine Rahali, David Standring, Virginie Roques, Francois-Rene Alexandre, Maria Seifer, Anna-Giulia Loi, Damien Gloux, Christophe Claude Parsy, Elodie Rosinovsky, Dominique Chaves, Catherine Caillet, Frederic Leroy, Guillaume Brandt, Dominique Louis Nestor Ghislain Surleraux, Sylvie Cappelle, Yann Griffon, Simon Savin, Musiu Chiara, Laure Moulat, Michel Liuzzi, Michel Derock
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 25:5427-5436
Exploration of the P2 region by mimicking the proline motif found in BILN2061 resulted in the discovery of two series of potent HCV NS3/4A protease inhibitors. X-ray crystal structure of the ligand in contact with the NS3/4A protein and modulation of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e4b62addc3e995acb26693574bacaff
https://doi.org/10.1016/j.bmcl.2015.09.009
https://doi.org/10.1016/j.bmcl.2015.09.009
Autor:
François-René Alexandre, Eric Badaroux, John P. Bilello, Stéphanie Bot, Tony Bouisset, Guillaume Brandt, Sylvie Cappelle, Christopher Chapron, Dominique Chaves, Thierry Convard, Clément Counor, Daniel Da Costa, David Dukhan, Marion Gay, Gilles Gosselin, Jean-François Griffon, Kusum Gupta, Brenda Hernandez-Santiago, Massimiliano La Colla, Marie-Pierre Lioure, Julien Milhau, Jean-Laurent Paparin, Jérôme Peyronnet, Christophe Parsy, Claire Pierra Rouvière, Houcine Rahali, Rachid Rahali, Aurélien Salanson, Maria Seifer, Ilaria Serra, David Standring, Dominique Surleraux, Cyril B. Dousson
Publikováno v:
Bioorganicmedicinal chemistry letters. 27(18)
Herein we describe the discovery of IDX21437 35b, a novel RPd-aminoacid-based phosphoramidate prodrug of 2'-α-chloro-2'-β-C-methyluridine monophosphate. Its corresponding triphosphate 6 is a potent inhibitor of the HCV NS5B RNA-dependent RNA polyme
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8795b8e1e924d640806c19eaa1d19ab
https://pubmed.ncbi.nlm.nih.gov/28835346
https://pubmed.ncbi.nlm.nih.gov/28835346
Autor:
Yann Griffon, Michel Derock, Damien Gloux, Francois-Rene Alexandre, Maria Seifer, Chiara Musiu, Christophe Claude Parsy, Houcine Rahali, Dominique Louis Nestor Ghislain Surleraux, Anna-Giulia Loi, Sylvie Cappelle, Frederic Leroy, Thierry Convard, Guillaume Brandt, Dominique Chaves, L.B. Lallos, Virginie Roques, David Standring, Laure Moulat, Michel Liuzzi, Catherine Caillet
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 24:4444-4449
Structural homology between thrombin inhibitors and the early tetrapeptide HCV protease inhibitor led to the bioisosteric replacement of the P2 proline by a 2,4-disubstituted azetidine within the macrocyclic β-strand mimic. Molecular modeling guided
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cfff91a6a2e65ed794eec1aeb024c276
https://doi.org/10.1016/j.bmcl.2014.08.002
https://doi.org/10.1016/j.bmcl.2014.08.002
Autor:
Maria Seifer, J. Gillum, Ilaria Serra, L.B. Lallos, David Standring, M. La Colla, Claire Pierra, J. Mccarville, John P. Bilello, C. Chapron
Publikováno v:
Antimicrobial Agents and Chemotherapy. 58:4431-4442
The hepatitis C virus (HCV) nonstructural 5A (NS5A) protein is a clinically validated target for drugs designed to treat chronic HCV infection. This study evaluated the in vitro activity, selectivity, and resistance profile of a novel anti-HCV compou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3e88a25bd6f81d661bc9b2b2a61753f
https://doi.org/10.1128/aac.02777-13
https://doi.org/10.1128/aac.02777-13
Autor:
Jean-Laurent Paparin, Thierry Convard, Catherine Caillet, Stéphanie Bot, Dominique Louis Nestor Ghislain Surleraux, Claire Pierra, Valeria Mascia, Maria Seifer, Jean-François Griffon, Efisio Sais, Agnès Amador, David Dukhan, Cyril B. Dousson, Elodie Rosinosky, Loredana Onidi, Anna Giulia Loi, Rachid Rahali, Eric Badaroux, Massimiliano LaColla, Frédéric Leroy, David Standring, Michel Liuzzi, Joe McCarville, Julien Milhau, Ludovic Griffe, Daniel Da Costa
Publikováno v:
Bioorganicmedicinal chemistry letters. 27(11)
Hepatitis C virus (HCV) NS5B RNA-dependent RNA polymerase (RdRp) plays a central role in virus replication. NS5B has no functional equivalent in mammalian cells, and as a consequence is an attractive target for selective inhibition. This paper descri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2cabbb65889368ef3bd04a5068480e29
https://pubmed.ncbi.nlm.nih.gov/28416131
https://pubmed.ncbi.nlm.nih.gov/28416131
Publikováno v:
Antiviral Research. 81:147-155
Telbivudine, a nucleoside analog inhibitor of the viral polymerase of hepatitis B virus (HBV), has been approved for the treatment of chronic HBV infection, along with the nucleoside inhibitors lamivudine and entecavir, and the nucleotide inhibitors
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::009ffe10e30594bb1d81019f94191922
https://doi.org/10.1016/j.antiviral.2008.10.008
https://doi.org/10.1016/j.antiviral.2008.10.008
Autor:
Dominique Louis Nestor Ghislain Surleraux, Yann Griffon, Christophe Claude Parsy, David Standring, Dominique Chaves, Houcine Rahali, Frederic Leroy, Chiara Musiu, Anna-Giulia Loi, L.B. Lallos, Catherine Caillet, Francois-Rene Alexandre, Maria Seifer, Michel Liuzzi, Damien Gloux, Laure Moulat, Thierry Convard, Michel Derock, Guillaume Brandt, Virginie Roques
Publikováno v:
Bioorganicmedicinal chemistry letters. 25(18)
We disclose here the synthesis of a series of macrocyclic HCV protease inhibitors, where the homoserine linked together the quinoline P2' motif and the macrocyclic moiety. These compounds exhibit potent inhibitory activity against HCV NS3/4A protease
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f00c2f8b97ed58ce2be3c171d1b330bc
https://pubmed.ncbi.nlm.nih.gov/26231161
https://pubmed.ncbi.nlm.nih.gov/26231161
Autor:
David Standring, Maria Seifer
Publikováno v:
Intervirology. 38:295-303
Human hepatitis B virus (HBV) polymerase (pol or RT), when expressed in Xenopus oocytes upon injection of synthetic minimal pol RNA (RT RNA), assembles into a higher molecular weight complex with the characteristics of a ribonuclear protein (RNP) com
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::934c638d62b9555df850856892378940
https://doi.org/10.1159/000150454
https://doi.org/10.1159/000150454
Autor:
Maria Seifer, David Standring
Publikováno v:
Virology. 196:70-78
The p21.5 capsid or core protein of hepatitis B virus carries two distinct classes of epitopes. Core (HBc) epitopes are found exclusively on the surface of the 28-nm viral icosahedral capsids or core particles, while HBe epitopes are normally express
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6265aae6b58d15911ff30085c0ba940
https://doi.org/10.1006/viro.1993.1455
https://doi.org/10.1006/viro.1993.1455