Zobrazeno 1 - 10
of 395
pro vyhledávání: '"David StC. Black"'
Autor:
Vina R. Aldilla, Renxun Chen, Rajesh Kuppusamy, Sudip Chakraborty, Mark D. P. Willcox, David StC. Black, Pall Thordarson, Adam D. Martin, Naresh Kumar
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-12 (2022)
Abstract In this study, we prepared antibacterial hydrogels through the self-assembly of naphthyl anthranilamide (NaA) capped amino acid based cationic peptide mimics. These ultra-short cationic peptide mimics were rationally designed with NaA as a c
Externí odkaz:
https://doaj.org/article/739cf1fdba564463a042d623a1edc1f9
Publikováno v:
Molecules, Vol 29, Iss 1, p 166 (2023)
A synthetic pathway to a novel 4-aryl-3,4-dihydro-2H-1,4-benzoxazine scaffold was developed and a series of compounds based on the scaffold were synthesised as potential anticancer agents. The 4-aryl-substituted compounds were prepared via Buchwald
Externí odkaz:
https://doaj.org/article/cab612ed311441b0965de8c04a996d85
Publikováno v:
Antibiotics, Vol 12, Iss 7, p 1227 (2023)
As bacteria continue to develop resistance mechanisms against antimicrobials, an alternative method to tackle this global concern must be developed. As the pqs system is the most well-known and responsible for biofilm and pyocyanin production, quinaz
Externí odkaz:
https://doaj.org/article/dce45bf384e04a0998fb7e2cd3830c6f
Autor:
Ghayah Bahatheg, Rajesh Kuppusamy, Muhammad Yasir, David StC. Black, Mark Willcox, Naresh Kumar
Publikováno v:
Antibiotics, Vol 11, Iss 8, p 1074 (2022)
Peptoids are peptidomimetics that have attracted considerable interest as a promising class of antimicrobials against multi-drug-resistant bacteria due to their resistance to proteolysis, bioavailability, and thermal stability compared to their corre
Externí odkaz:
https://doaj.org/article/bdfdc3c7c50445c2ac78c34f0b607def
Autor:
Jie Wu, Tsz Tin Yu, Rajesh Kuppusamy, Md. Musfizur Hassan, Amani Alghalayini, Charles G. Cranfield, Mark D. P. Willcox, David StC. Black, Naresh Kumar
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 9, p 4623 (2022)
There is a significant and urgent need for the development of novel antibacterial agents to tackle the increasing incidence of antibiotic resistance. Cholic acid-based small molecular antimicrobial peptide mimics are reported as potential new leads t
Externí odkaz:
https://doaj.org/article/bc736b1d103244eb8d6b22793d0352fe
Autor:
Katrina Browne, Rajesh Kuppusamy, Renxun Chen, Mark D. P. Willcox, William R. Walsh, David StC. Black, Naresh Kumar
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 6, p 2952 (2022)
The prevention and treatment of biofilm-mediated infections remains an unmet clinical need for medical devices. With the increasing prevalence of antibiotic-resistant infections, it is important that novel approaches are developed to prevent biofilms
Externí odkaz:
https://doaj.org/article/4f984162580a4843b05d6779a77cce17
Autor:
Basmah Almohaywi, Tsz Tin Yu, George Iskander, Shekh Sabir, Mohan Bhadbhade, David StC. Black, Naresh Kumar
Publikováno v:
Antibiotics, Vol 11, Iss 2, p 151 (2022)
The Quorum-sensing system in Pseudomonas aeruginosa is responsible for the pathogenicity and the production of virulence factors and biofilm formation. Dihydropyrrolones were previously found to act as inhibitors of QS-dependent bacterial phenotypes.
Externí odkaz:
https://doaj.org/article/f140969dd3564e1fb30a2eef0962d63a
Autor:
Murat Bingul, Greg M. Arndt, Glenn M. Marshall, David StC. Black, Belamy B. Cheung, Naresh Kumar
Publikováno v:
Molecules, Vol 26, Iss 19, p 5745 (2021)
The dihydropyranoindole structures were previously identified as promising scaffolds for improving the anti-cancer activity of histone deacetylase inhibitors. This work describes the synthesis of related furoindoles and their ability to synergize wit
Externí odkaz:
https://doaj.org/article/5ac922c7d9514cd0856e8892e2cfc186
Autor:
Tsz Tin Yu, Rajesh Kuppusamy, Muhammad Yasir, Md. Musfizur Hassan, Manjulatha Sara, Junming Ho, Mark D. P. Willcox, David StC. Black, Naresh Kumar
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 14, p 7344 (2021)
The rapid emergence of drug-resistant bacteria is a major global health concern. Antimicrobial peptides (AMPs) and peptidomimetics have arisen as a new class of antibacterial agents in recent years in an attempt to overcome antibiotic resistance. A l
Externí odkaz:
https://doaj.org/article/452783ec93474663a6c5aec28c2d0436
Autor:
Dittu Suresh, Shekh Sabir, Tsz Tin Yu, Daniel Wenholz, Theerthankar Das, David StC. Black, Naresh Kumar
Publikováno v:
Molecules, Vol 26, Iss 12, p 3745 (2021)
Rottlerin is a natural product consisting of chalcone and flavonoid scaffolds, both of which have previously shown quorum sensing (QS) inhibition in various bacteria. Therefore, the unique rottlerin scaffold highlights great potential in inhibiting t
Externí odkaz:
https://doaj.org/article/0e22734d31c3472289f970c1e404f2d1