Zobrazeno 1 - 10 of 76 pro vyhledávání: '"David Spafford"'
1
Akademický článek
A governance of ion selectivity based on the occupancy of the 'beacon' in one- and four-domain calcium and sodium channels
Autor: J. David Spafford
Publikováno v: Channels, Vol 17, Iss 1 (2023)
ABSTRACTOne of nature’s exceptions was discovered when a Cav3 T-type channel was observed to switch phenotype from a calcium channel into a sodium channel by neutralizing an aspartate residue in the high field strength (HFS) +1 position within the
Externí odkaz: https://doaj.org/article/73f95db918a1477598b4cddc9b669fc5
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2
Akademický článek
Asynchronous Delivery of a 400 Level, Partially Peer-Graded, Oral Presentation and Discussion Course in Systems Neuroscience for 60 Students during the COVID-19 Pandemic
Autor: Jack Moffat, Charlotte Copas, Kate Wood, J. David Spafford
Publikováno v: Brain Sciences, Vol 11, Iss 6, p 693 (2021)
A 400-level undergraduate oral presentation and discussion course in Systems Neuroscience was delivered asynchronously online during the COVID-19 pandemic. Enrolled students banked their narrated oral presentations in video format online then engaged
Externí odkaz: https://doaj.org/article/2c44714ee06a497093bb118eccf26cb9
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4
Akademický článek
Eukaryotic Voltage-Gated Sodium Channels: On Their Origins, Asymmetries, Losses, Diversification and Adaptations
Autor: Julia E. Fux, Amrit Mehta, Jack Moffat, J. David Spafford
Publikováno v: Frontiers in Physiology, Vol 9 (2018)
The appearance of voltage-gated, sodium-selective channels with rapid gating kinetics was a limiting factor in the evolution of nervous systems. Two rounds of domain duplications generated a common 24 transmembrane segment (4 × 6 TM) template that i
Externí odkaz: https://doaj.org/article/7df6282f3810458ca398ba4306f9c289
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8
A lysine residue from an extracellular turret switches the ion preference in a Cav3 T-Type channel from calcium to sodium ions
Autor: Wendy Guan, Kaidy G. Orellana, Robert F. Stephens, Boris S. Zhorov, J. David Spafford
Publikováno v: Journal of Biological Chemistry. 298:102621
Cav3 T-type calcium channels from great pond snail Lymnaea stagnalis have a selectivity-filter ring of five acidic residues, EE(D)DD. Splice variants with exons 12b or 12a spanning the extracellular loop between the outer helix IIS5 and membrane-desc
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae6618ed095e249c9b5f47cfd72c24d1
https://doi.org/10.1016/j.jbc.2022.102621
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10
Akademický článek
Gd3+ and calcium sensitive, sodium leak currents are features of weak membrane-glass seals in patch clamp recordings.
Autor: Adrienne N Boone, Adriano Senatore, Jean Chemin, Arnaud Monteil, J David Spafford
Publikováno v: PLoS ONE, Vol 9, Iss 6, p e98808 (2014)
The properties of leaky patch currents in whole cell recording of HEK-293T cells were examined as a means to separate these control currents from expressed sodium and calcium leak channel currents from snail NALCN leak channels possessing both sodium
Externí odkaz: https://doaj.org/article/ede0ab7787d044dd8121c6319d466fea
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